- Crystal Structure of Albaflavenone Monooxygenase Containing a Moonlighting Terpene Synthase Active Site
[作者:Zhao, B; Lei, L; Vassylyev, DG; Lin, X; Cane, DE; Kelly, SL; Yuan, H; Lamb, DC; Waterman, MR,期刊:Journal of Biological Chemistry, 页码:36711-36719 , 文章类型: Article,,卷期:2009年284-52]
- Albaflavenone synthase (CYP170A1) is a monooxygenase catalyzing the final two steps in the biosynthesis of this antibiotic in the soil bacterium, Streptomyces coelicolor A3(2). Interestingly, CYP170A1 shows no stereo sel...
- Mutant N143P Reveals How Na+ Activates Thrombin
[作者:Niu, WL; Chen, ZW; Bush-Pelc, LA; Bah, A; Gandhi, PS; Di Cera, E,期刊:Journal of Biological Chemistry, 页码:36175-36185 , 文章类型: Review,,卷期:2009年284-52]
- The molecular mechanism of thrombin activation by Na+ remains elusive. Its kinetic formulation requires extension of the classical Botts-Morales theory for the action of a modifier on an enzyme to correctly account for t...
- High Speed Atomic Force Microscopy Visualizes Processive Movement of Trichoderma reesei Cellobiohydrolase I on Crystalline Cellulose
[作者:Igarashi, K; Koivula, A; Wada, M; Kimura, S; Penttila, M; Samejima, M,期刊:Journal of Biological Chemistry, 页码:36186-36190 , 文章类型: Article,,卷期:2009年284-52]
- Fungal cellobiohydrolases act at liquid-solid interfaces. They have the ability to hydrolyze cellulose chains of a crystalline substrate because of their two-domain structure, i.e. cellulose-binding domain and catalytic ...
- Mitochondrial DNA Damage Initiates a Cell Cycle Arrest by a Chk2-associated Mechanism in Mammalian Cells
[作者:Koczor, CA; Shokolenko, IN; Boyd, AK; Balk, SP; Wilson, GL; LeDoux, SP,期刊:Journal of Biological Chemistry, 页码:36191-36201 , 文章类型: Article,,卷期:2009年284-52]
- Previous work from our laboratory has focused on mitochondrial DNA (mtDNA) repair and cellular viability. However, other events occur prior to the initiation of apoptosis in cells. Because of the importance of mtDNA in A...
- Molecular Basis for Galactosylation of Core Fucose Residues in Invertebrates IDENTIFICATION OF CAENORHABDITIS ELEGANS N-GLYCAN CORE alpha 1,6-FUCOSIDE beta 1,4-GALACTOSYLTRANSFERASE GALT-1 AS A MEMBER OF A NOVEL GLYCOSYLTRANSFERASE FAMILY
[作者:Titz, A; Butschi, A; Henrissat, B; Fan, YY; Hennet, T; Razzazi-Fazeli, E; Hengartner, MO; Wilson, IBH; Kunzler, M; Aebi, M,期刊:Journal of Biological Chemistry, 页码:36223-36233 , 文章类型: Article,,卷期:2009年284-52]
- Galectin CGL2 from the ink cap mushroom Coprinopsis cinerea displays toxicity toward the model nematode Caenorhabditis elegans. A mutation in a putative glycosyltransferase-encoding gene resulted in a CGL2-resistant C. e...
- Williams-Beuren Syndrome-associated Transcription Factor TFII-I Regulates Osteogenic Marker Genes
[作者:Lazebnik, MB; Tussie-Luna, MI; Hinds, PW; Roy, AL,期刊:Journal of Biological Chemistry, 页码:36234-36239 , 文章类型: Article,,卷期:2009年284-52]
- Williams-Beuren syndrome (WBS), an autosomal dominant genetic disorder, is characterized by a unique cognitive profile and craniofacial defects. WBS results from a microdeletion at the chromosomal location 7q11.23 that e...
- Regulation of Iron Homeostasis in Arabidopsis thaliana by the Clock Regulator Time for Coffee
[作者:Duc, C; Cellier, F; Lobreaux, S; Briat, JF; Gaymard, F,期刊:Journal of Biological Chemistry, 页码:36271-36281 , 文章类型: Article,,卷期:2009年284-52]
- In plants, iron homeostasis is tightly regulated to supply sufficient amounts of this metal for an optimal growth while preventing excess accumulation to avoid oxidative stress. To identify new regulators of iron homeost...
- Regulation by Glutathionylation of Isocitrate Lyase from Chlamydomonas reinhardtii
[作者:Bedhomme, M; Zaffagnini, M; Marchand, CH; Gao, XH; Moslonka-Lefebvre, M; Michelet, L; Decottignies, P; Lemaire, SD,期刊:Journal of Biological Chemistry, 页码:36282-36291 , 文章类型: Article,,卷期:2009年284-52]
- Post-translational modification of protein cysteine residues is emerging as an important regulatory and signaling mechanism. We have identified numerous putative targets of redox regulation in the unicellular green alga ...
- Zinc Protoporphyrin Regulates Cyclin D1 Expression Independent of Heme Oxygenase Inhibition
[作者:La, P; Fernando, AP; Wang, Z; Salahudeen, A; Yang, G; Lin, Q; Wright, CJ; Dennery, PA,期刊:Journal of Biological Chemistry, 页码:36302-36311 , 文章类型: Article,,卷期:2009年284-52]
- Zinc protoporphyrin IX (ZnPP), an endogenous heme analogue that inhibits heme oxygenase (HO) activity, represses tumor growth. It can also translocate into the nucleus and up-regulate heme oxygenase 1 (HMOX1) gene expres...
- DGAT1 Expression Increases Heart Triglyceride Content but Ameliorates Lipotoxicity
[作者:Liu, L; Shi, XJ; Bharadwaj, KG; Ikeda, S; Yamashita, H; Yagyu, H; Schaffer, JE; Yu, YH; Goldberg, IJ,期刊:Journal of Biological Chemistry, 页码:36312-36323 , 文章类型: Article,,卷期:2009年284-52]
- Intracellular lipid accumulation in the heart is associated with cardiomyopathy, yet the precise role of triglyceride (TG) remains unclear. With exercise, wild type hearts develop physiologic hypertrophy. This was associ...
- Modulating Effects of the Plug, Helix, and N- and C-terminal Domains on Channel Properties of the PapC Usher
[作者:Mapingire, OS; Henderson, NS; Duret, G; Thanassi, DG; Delcour, AH,期刊:Journal of Biological Chemistry, 页码:36324-36333 , 文章类型: Article,,卷期:2009年284-52]
- The chaperone/usher system is one of the best characterized pathways for protein secretion and assembly of cell surface appendages in Gram-negative bacteria. In particular, this pathway is used for biogenesis of the P pi...
|