- Oxidative Status of DJ-1-dependent Activation of Dopamine Synthesis through Interaction of Tyrosine Hydroxylase and 4-Dihydroxy-L-phenylalanine (L-DOPA) Decarboxylase with DJ-1
[作者:Ishikawa, S; Taira, T; Niki, T; Takahashi-Niki, K; Maita, C; Maita, H; Ariga, H; Iguchi-Ariga, SMM,期刊:Journal of Biological Chemistry, 页码:28832-28844 , 文章类型: Article,,卷期:2009年284-42]
- Parkinson disease (PD) is caused by loss of dopamine, which is synthesized from tyrosine by two enzymes, tyrosine hydroxylase (TH) and 4-dihydroxy-L-phenylalanine decarboxylase (DDC). DJ-1 is a causative gene for the fam...
- Functional Complementation in Yeast Allows Molecular Characterization of Missense Argininosuccinate Lyase Mutations
[作者:Trevisson, E; Burlina, A; Doimo, M; Pertegato, V; Casarin, A; Cesaro, L; Navas, P; Basso, G; Sartori, G; Salviati, L,期刊:Journal of Biological Chemistry, 页码:28926-28934 , 文章类型: Article,,卷期:2009年284-42]
- Deficiency of argininosuccinate lyase (ASL) causes argininosuccinic aciduria, an urea cycle defect that may present with a severe neonatal onset form or with a late onset phenotype. To date phenotype-genotype correlation...
- Functional Interaction between the Fanconi Anemia D2 Protein and Proliferating Cell Nuclear Antigen (PCNA) via a Conserved Putative PCNA Interaction Motif
[作者:Howlett, NG; Harney, JA; Rego, MA; Kolling, FW; Glover, TW,期刊:Journal of Biological Chemistry, 页码:28935-28942 , 文章类型: Article,,卷期:2009年284-42]
- Fanconi Anemia (FA) is a rare recessive disease characterized by congenital abnormalities, bone marrow failure, and cancer susceptibility. The FA proteins and the familial breast cancer susceptibility gene products, BRCA...
- Crystal Structures and Biochemical Analyses Suggest a Unique Mechanism and Role for Human Glycyl-tRNA Synthetase in Ap4A Homeostasis
[作者:Guo, RT; Chong, YE; Guo, M; Yang, XL,期刊:Journal of Biological Chemistry, 页码:28968-28976 , 文章类型: Article,,卷期:2009年284-42]
- Aminoacyl-tRNA synthetases catalyze the attachment of amino acids to their cognate tRNAs for protein synthesis. However, the aminoacylation reaction can be diverted to produce diadenosine tetraphosphate (Ap4A), a univers...
- Inhibition of Schistosoma mansoni Thioredoxin-glutathione Reductase by Auranofin STRUCTURAL AND KINETIC ASPECTS
[作者:Angelucci, F; Sayed, AA; Williams, DL; Boumis, G; Brunori, M; Dimastrogiovanni, D; Miele, AE; Pauly, F; Bellelli, A,期刊:Journal of Biological Chemistry, 页码:28977-28985 , 文章类型: Article,,卷期:2009年284-42]
- Schistosomiasis is a parasitic disease affecting over 200 million people currently treated with one drug, praziquantel. A possible drug target is the seleno-protein thioredoxin-glutathione reductase (TGR), a key enzyme i...
- N-Myristoylated c-Abl Tyrosine Kinase Localizes to the Endoplasmic Reticulum upon Binding to an Allosteric Inhibitor
[作者:Choi, Y; Seeliger, MA; Panjarian, SB; Kim, H; Deng, X; Sim, T; Couch, B; Koleske, AJ; Smithgall, TE; Gray, NS,期刊:Journal of Biological Chemistry, 页码:29005-29014 , 文章类型: Article,,卷期:2009年284-42]
- Allosteric kinase inhibitors hold promise for revealing unique features of kinases that may not be apparent using conventional ATP-competitive inhibitors. Here we explore the activity of a previously reported allosteric ...
- HRP-2, the Caenorhabditis elegans Homolog of Mammalian Heterogeneous Nuclear Ribonucleoproteins Q and R, Is an Alternative Splicing Factor That Binds to UCUAUC Splicing Regulatory Elements
[作者:Kabat, JL; Barberan-Soler, S; Zahler, AM,期刊:Journal of Biological Chemistry, 页码:28490-28497 , 文章类型: Article,,卷期:2009年284-42]
- Alternative splicing is regulated by cis sequences in the pre-mRNA that serve as binding sites for trans-acting alternative splicing factors. In a previous study, we used bioinformatics and molecular biology to identify ...
- Localized Diacylglycerol-dependent Stimulation of Ras and Rap1 during Phagocytosis
[作者:Botelho, RJ; Harrison, RE; Stone, JC; Hancock, JF; Philips, MR; Jongstra-Bilen, J; Mason, D; Plumb, J; Gold, MR; Grinstein, S,期刊:Journal of Biological Chemistry, 页码:28522-28532 , 文章类型: Article,,卷期:2009年284-42]
- We describe a role for diacylglycerol in the activation of Ras and Rap1 at the phagosomal membrane. During phagocytosis, Ras density was similar on the surface and invaginating areas of the membrane, but activation was d...
- Analysis of Non-canonical Fibroblast Growth Factor Receptor 1 (FGFR1) Interaction Reveals Regulatory and Activating Domains of Neurofascin
[作者:Kirschbaum, K; Kriebel, M; Kranz, EU; Potz, O; Volkmer, H,期刊:Journal of Biological Chemistry, 页码:28533-28542 , 文章类型: Article,,卷期:2009年284-42]
- Fibroblast growth factor receptors (FGFRs) are important for many different mechanisms, including cell migration, proliferation, differentiation, and survival. Here, we show a new link between FGFR1 and the cell adhesion...
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