- CD38/cADPR/Ca2+ Pathway Promotes Cell Proliferation and Delays Nerve Growth Factor-induced Differentiation in PC12 Cells
[作者:Yue, JB; Wei, WJ; Lam, CMC; Zhao, YJ; Dong, M; Zhang, LR; Zhang, LH; Lee, HC,期刊:Journal of Biological Chemistry, 页码:29335-29342 , 文章类型: Article,,卷期:2009年284-43]
- Intracellular Ca2+ mobilization plays an important role in a wide variety of cellular processes, and multiple second messengers are responsible for mediating intracellular Ca2+ changes. Here we explored the role of one e...
- Glu-333 of Nicastrin Directly Participates in gamma-Secretase Activity
[作者:Dries, DR; Shah, S; Han, YH; Yu, C; Yu, S; Shearman, MS; Yu, G,期刊:Journal of Biological Chemistry, 页码:29714-29724 , 文章类型: Article,,卷期:2009年284-43]
- gamma-Secretase is a proteolytic membrane complex that processes a variety of substrates including the amyloid precursor protein and the Notch receptor. Earlier we showed that one of the components of this complex, nicas...
- Ischemia Activates the ATF6 Branch of the Endoplasmic Reticulum Stress Response
[作者:Doroudgar, S; Thuerauf, DJ; Marcinko, MC; Belmont, PJ; Glembotski, CC,期刊:Journal of Biological Chemistry, 页码:29735-29745 , 文章类型: Article,,卷期:2009年284-43]
- Stresses that perturb the folding of nascent endoplasmic reticulum (ER) proteins activate the ER stress response. Upon ER stress, ER-associated ATF6 is cleaved; the resulting active cytosolic fragment of ATF6 translocate...
- Oxidative Cleavage of Diverse Ethers by an Extracellular Fungal Peroxygenase
[作者:Kinne, M; Poraj-Kobielska, M; Ralph, SA; Ullrich, R; Hofrichter, M; Hammel, KE,期刊:Journal of Biological Chemistry, 页码:29343-29349 , 文章类型: Article,,卷期:2009年284-43]
- Many litter-decay fungi secrete heme-thiolate peroxygenases that oxidize various organic chemicals, but little is known about the role or mechanism of these enzymes. We found that the extracellular peroxygenase of Agrocy...
- iso-Migrastatin, Migrastatin, and Dorrigocin Production in Streptomyces platensis NRRL 18993 Is Governed by a Single Biosynthetic Machinery Featuring an Acyltransferase-less Type I Polyketide Synthase
[作者:Lim, SK; Ju, JH; Zazopoulos, E; Jiang, H; Seo, JW; Chen, YH; Feng, ZY; Rajski, SR; Farnet, CM; Shen, B,期刊:Journal of Biological Chemistry, 页码:29746-29756 , 文章类型: Article,,卷期:2009年284-43]
- iso-Migrastatin and related glutarimide-containing polyketides are potent inhibitors of tumor cell migration and their implied potential as antimetastatic agents for human cancers has garnered significant attention. Geno...
- Endothelial and Smooth Muscle-derived Neuropilin-like Protein Regulates Platelet-derived Growth Factor Signaling in Human Vascular Smooth Muscle Cells by Modulating Receptor Ubiquitination
[作者:Guo, XJ; Nie, L; Esmailzadeh, L; Zhang, JS; Bender, JR; Sadeghi, MM,期刊:Journal of Biological Chemistry, 页码:29376-29382 , 文章类型: Article,,卷期:2009年284-43]
- Endothelial and smooth muscle cell-derived neuropilin-like protein (ESDN) is up-regulated in the neointima of remodeling arteries and modulates vascular smooth muscle cell (VSMC) growth. Platelet-derived growth factor (P...
- RNA-destabilizing Factor Tristetraprolin Negatively Regulates NF-kappa B Signaling
[作者:Liang, J; Lei, TH; Song, YT; Yanes, N; Qi, YF; Fu, MG,期刊:Journal of Biological Chemistry, 页码:29383-29390 , 文章类型: Article,,卷期:2009年284-43]
- Tristetraprolin (TTP) is a CCCH zinc finger-containing protein that destabilizes mRNA by binding to an AU-rich element. Mice deficient in TTP develop a severe inflammatory syndrome mainly because of overproduction of tum...
- Lipopolysaccharide-driven Th2 Cytokine Production in Macrophages Is Regulated by Both MyD88 and TRAM
[作者:Mukherjee, S; Chen, LY; Papadimos, TJ; Huang, S; Zuraw, BL; Pan, ZK,期刊:Journal of Biological Chemistry, 页码:29391-29398 , 文章类型: Article,,卷期:2009年284-43]
- Gram-negative bacterial lipopolysaccharide (LPS) activates macrophages by interacting with Toll-like receptor 4 (TLR4) and triggers the production of various pro-inflammatory Th1 type (type 1) cytokines such as IFN gamma...
- Thiazolides, a New Class of Anti-influenza Molecules Targeting Viral Hemagglutinin at the Post-translational Level
[作者:Rossignol, JF; La Frazia, S; Chiappa, L; Ciucci, A; Santoro, MG,期刊:Journal of Biological Chemistry, 页码:29798-29808 , 文章类型: Article,,卷期:2009年284-43]
- The emergence of highly contagious influenza A virus strains, such as the new H1N1 swine influenza, represents a serious threat to global human health. Efforts to control emerging influenza strains focus on surveillance ...
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