- The Proteasome Is an Integral Part of Solar Ultraviolet A Radiation-induced Gene Expression
[作者:Catalgol, B; Ziaja, I; Breusing, N; Jung, T; Hohn, A; Alpertunga, B; Schroeder, P; Chondrogianni, N; Gonos, ES; Petropoulos, I; Friguet, B; Klotz, LO; Krutmann, J; Grune, T,期刊:Journal of Biological Chemistry, 页码:30076-30086 , 文章类型: Article,,卷期:2009年284-44]
- Solar ultraviolet (UV) A radiation is a well known trigger of signaling responses in human skin fibroblasts. One important consequence of this stress response is the increased expression of matrix metalloproteinase-1 (MM...
- Aldosterone Modulates Steroid Receptor Binding to the Endothelin-1 Gene (edn1)
[作者:Stow, LR; Gumz, ML; Lynch, IJ; Greenlee, MM; Rudin, A; Cain, BD; Wingo, CS,期刊:Journal of Biological Chemistry, 页码:30087-30096 , 文章类型: Article,,卷期:2009年284-44]
- Aldosterone and endothelin-1 (ET-1) act on collecting duct cells of the kidney and are important regulators of renal sodium transport and cardiovascular physiology. We recently identified the ET-1 gene (edn1) as a novel ...
- Peroxisome Proliferator-activated Receptor gamma Agonist Rosiglitazone Increases Expression of Very Low Density Lipoprotein Receptor Gene in Adipocytes
[作者:Takazawa, T; Yamauchi, T; Tsuchida, A; Takata, M; Hada, Y; Iwabu, M; Okada-Iwabu, M; Ueki, K; Kadowaki, T,期刊:Journal of Biological Chemistry, 页码:30049-30057 , 文章类型: Article,,卷期:2009年284-44]
- Apolipoprotein E (apoE) and its receptor, very low density lipoprotein receptor (VLDLR), are involved in fat accumulation in adipocytes. Here, we investigated the effect of a peroxisome proliferator-activated receptor (P...
- Crowded Cell-like Environment Accelerates the Nucleation Step of Amyloidogenic Protein Misfolding
[作者:Zhou, Z; Fan, JB; Zhu, HL; Shewmaker, F; Yan, X; Chen, X; Chen, J; Xiao, GF; Guo, L; Liang, Y,期刊:Journal of Biological Chemistry, 页码:30148-30158 , 文章类型: Article,,卷期:2009年284-44]
- To understand the role of a crowded physiological environment in the pathogenesis of neurodegenerative diseases, we report the following. 1) The formation of fibrous aggregates of the human Tau fragment Tau-(244-441), wh...
- Pigment Epithelium-derived Factor Maintains Retinal Pigment Epithelium Function by Inhibiting Vascular Endothelial Growth Factor-R2 Signaling through gamma-Secretase
[作者:Ablonczy, Z; Prakasam, A; Fant, J; Fauq, A; Crosson, C; Sambamurti, K,期刊:Journal of Biological Chemistry, 页码:30177-30186 , 文章类型: Article,,卷期:2009年284-44]
- Wet age-related macular degeneration (AMD) attacks the integrity of the retinal pigment epithelium (RPE) barrier system. The pathogenic process was hypothesized to be mediated by vascular endothelial growth factor (VEGF)...
- Dual Targeting of Nfs1 and Discovery of Its Novel Processing Enzyme, Icp55
[作者:Naamati, A; Regev-Rudzki, N; Galperin, S; Lill, R; Pines, O,期刊:Journal of Biological Chemistry, 页码:30200-30208 , 文章类型: Article,,卷期:2009年284-44]
- In eukaryotes, each subcellular compartment harbors a specific group of proteins that must accomplish specific tasks. Nfs1 is a highly conserved mitochondrial cysteine desulfurase that participates in iron-sulfur cluster...
- HNK-1 Glyco-epitope Regulates the Stability of the Glutamate Receptor Subunit GluR2 on the Neuronal Cell Surface
[作者:Morita, I; Kakuda, S; Takeuchi, Y; Itoh, S; Kawasaki, N; Kizuka, Y; Kawasaki, T; Oka, S,期刊:Journal of Biological Chemistry, 页码:30209-30217 , 文章类型: Article,,卷期:2009年284-44]
- HNK-1 (human natural killer-1) glyco-epitope, a sulfated glucuronic acid attached to N-acetyllactosamine on the nonreducing termini of glycans, is highly expressed in the nervous system. Our previous report showed that m...
- Peroxidase Activity of Hemoglobin.Haptoglobin Complexes COVALENT AGGREGATION AND OXIDATIVE STRESS IN PLASMA AND MACROPHAGES
[作者:Kapralov, A; Vlasova, II; Feng, WH; Maeda, A; Walson, K; Tyurin, VA; Huang, ZT; Aneja, RK; Carcillo, J; Bayir, H; Kagan, VE,期刊:Journal of Biological Chemistry, 页码:30395-30407 , 文章类型: Article,,卷期:2009年284-44]
- As a hemoprotein, hemoglobin (Hb) can, in the presence of H2O2, act as a peroxidase. In red blood cells, this activity is regulated by the reducing environment. For stroma-free Hb this regulation is lost, and the potenti...
- Integrator3, a Partner of Single-stranded DNA-binding Protein 1, Participates in the DNA Damage Response
[作者:Zhang, F; Wu, JX; Yu, XC,期刊:Journal of Biological Chemistry, 页码:30408-30415 , 文章类型: Article,,卷期:2009年284-44]
- Single-stranded DNA-binding protein 1 (SSB1) plays an important role in the DNA damage response and maintenance of genomic stability. Here, by using protein affinity purification, we have identified Integrator3 (INT3) as...
- A Non-canonical DNA Structure Enables Homologous Recombination in Various Genetic Systems
[作者:Masuda, T; Ito, Y; Terada, T; Shibata, T; Mikawa, T,期刊:Journal of Biological Chemistry, 页码:30230-30239 , 文章类型: Article,,卷期:2009年284-44]
- Homologous recombination, which is critical to genetic diversity, depends on homologous pairing (HP). HP is the switch from parental to recombinant base pairs, which requires expansion of inter-base pair spaces. This exp...
- Highly Conserved Cysteines within the Ly6 Domain of GPIHBP1 Are Crucial for the Binding of Lipoprotein Lipase
[作者:Beigneux, AP; Gin, P; Davies, BSJ; Weinstein, MM; Bensadoun, A; Fong, LG; Young, SG,期刊:Journal of Biological Chemistry, 页码:30240-30247 , 文章类型: Article,,卷期:2009年284-44]
- GPIHBP1, a glycosylphosphatidylinositol-anchored endothelial cell protein of the lymphocyte antigen 6 (Ly6) family, binds lipoprotein lipase (LPL) avidly and is required for the lipolytic processing of triglyceride-rich ...
- Regulation of the Interaction between Protein Kinase C-related Protein Kinase 2 (PRK2) and Its Upstream Kinase, 3-Phosphoinositide-dependent Protein Kinase 1 (PDK1)
[作者:Dettori, R; Sonzogni, S; Meyer, L; Lopez-Garcia, LA; Morrice, NA; Zeuzem, S; Engel, M; Piiper, A; Neimanis, S; Frodin, M; Biondi, RM,期刊:Journal of Biological Chemistry, 页码:30318-30327 , 文章类型: Article,,卷期:2009年284-44]
- The members of the AGC kinase family frequently exhibit three conserved phosphorylation sites: the activation loop, the hydrophobic motif (HM), and the zipper (Z)/turn-motif (TM) phosphorylation site. 3-Phosphoinositide-...
- Modulation of Nucleotide Excision Repair by Mammalian SWI/SNF Chromatin-remodeling Complex
[作者:Zhao, Q; Wang, QE; Ray, A; Wani, G; Han, CH; Milum, K; Wani, AA,期刊:Journal of Biological Chemistry, 页码:30424-30432 , 文章类型: Article,,卷期:2009年284-44]
- Accessibility within chromatin is an important factor in the prompt removal of UV-induced DNA damage by nucleotide excision repair (NER). Chromatin remodeling by the SWI/SNF complex has been shown to play an important mo...
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