- Differential Recognition and Hydrolysis of Host Carbohydrate Antigens by Streptococcus pneumoniae Family 98 Glycoside Hydrolases
[作者:Higgins, MA; Whitworth, GE; El Warry, N; Randriantsoa, M; Samain, E; Burke, RD; Vocadlo, DJ; Boraston, AB,期刊:Journal of Biological Chemistry, 页码:26161-26173 , 文章类型: Article,,卷期:2009年284-38]
- The presence of a fucose utilization operon in the Streptococcus pneumoniae genome and its established importance in virulence indicates a reliance of this bacterium on the harvesting of host fucose-containing glycans. T...
- Secretory Granule to the Nucleus ROLE OF A MULTIPLY PHOSPHORYLATED INTRINSICALLY UNSTRUCTURED DOMAIN
[作者:Rajagopal, C; Stone, KL; Francone, VP; Mains, RE; Eipper, BA,期刊:Journal of Biological Chemistry, 页码:25723-25734 , 文章类型: Article,,卷期:2009年284-38]
- Intrinsically unstructured domains occur in one-third of all proteins and are characterized by conformational flexibility, protease sensitivity, and the occurrence of multiple phosphorylation. They provide large interfac...
- Surf1, Associated with Leigh Syndrome in Humans, Is a Heme-binding Protein in Bacterial Oxidase Biogenesis
[作者:Bundschuh, FA; Hannappel, A; Anderka, O; Ludwig, B,期刊:Journal of Biological Chemistry, 页码:25735-25741 , 文章类型: Article,,卷期:2009年284-38]
- Biogenesis of mitochondrial cytochrome c oxidase (COX) relies on a large number of assembly factors, among them the transmembrane protein Surf1. The loss of human Surf1 function is associated with Leigh syndrome, a fatal...
- A TIR Domain Variant of MyD88 Adapter-like (Mal)/TIRAP Results in Loss of MyD88 Binding and Reduced TLR2/TLR4 Signaling
[作者:Nagpal, K; Plantinga, TS; Wong, J; Monks, BG; Gay, NJ; Netea, MG; Fitzgerald, KA; Golenbock, DT,期刊:Journal of Biological Chemistry, 页码:25742-25748 , 文章类型: Article,,卷期:2009年284-38]
- The adapter protein MyD88 adapter-like (Mal), encoded by TIR-domain containing adapter protein (Tirap) (MIM 606252), is the most polymorphic of the five adapter proteins involved in Toll-like receptor signaling, harborin...
- Silencing cAMP-response Element-binding Protein (CREB) Identifies CYR61 as a Tumor Suppressor Gene in Melanoma
[作者:Dobroff, AS; Wang, H; Melnikova, VO; Villares, GJ; Zigler, M; Huang, L; Bar-Eli, M,期刊:Journal of Biological Chemistry, 页码:26194-26206 , 文章类型: Article,,卷期:2009年284-38]
- Metastatic progression of melanoma is associated with overexpression and activity of cAMP-response element-binding protein (CREB). However, the mechanism by which CREB contributes to tumor progression and metastasis rema...
- Recognition Versus Adaptive Up-regulation and Degradation of CC Chemokines by the Chemokine Decoy Receptor D6 Are Determined by Their N-terminal Sequence
[作者:Savino, B; Borroni, EM; Torres, NM; Proost, P; Struyf, S; Mortier, A; Mantovani, A; Locati, M; Bonecchi, R,期刊:Journal of Biological Chemistry, 页码:26207-26215 , 文章类型: Article,,卷期:2009年284-38]
- The chemokine decoy receptor D6 controls inflammatory responses by selective recognition and degradation of most CCR1 to CCR5 agonistic ligands. CCL14 is a homeostatic chemokine present at high concentrations in the seru...
- Copper Transport in Mammalian Cells: Special Care for a Metal with Special Needs
[作者:Kaplan, JH; Lutsenko, S,期刊:Journal of Biological Chemistry, 页码:25461-25465 , 文章类型: Review,,卷期:2009年284-38]
- Copper plays an essential role in human physiology. It is required for respiration, radical defense, neuronal myelination, angiogenesis, and many other processes. Copper has distinct physicochemical properties that pose ...
- The Ca2+ Affinity of Synaptotagmin 1 Is Markedly Increased by a Specific Interaction of Its C2B Domain with Phosphatidylinositol 4,5-Bisphosphate
[作者:Radhakrishnan, A; Stein, A; Jahn, R; Fasshauer, D,期刊:Journal of Biological Chemistry, 页码:25749-25760 , 文章类型: Article,,卷期:2009年284-38]
- The synaptic vesicle protein synaptotagmin 1 is thought to convey the calcium signal onto the core secretory machinery. Its cytosolic portion mainly consists of two C2 domains, which upon calcium binding are enabled to b...
- A Functional P2X7 Splice Variant with an Alternative Transmembrane Domain 1 Escapes Gene Inactivation in P2X7 Knock-out Mice
[作者:Nicke, A; Kuan, YH; Masin, M; Rettinger, J; Marquez-Klaka, B; Bender, O; Gorecki, DC; Murrell-Lagnado, RD; Soto, F,期刊:Journal of Biological Chemistry, 页码:25813-25822 , 文章类型: Article,,卷期:2009年284-38]
- The ATP-activated P2X7 receptor channel is involved in immune function and inflammatory pain and represents an important drug target. Here we describe a new P2X7 splice variant (P2X7(k)), containing an alternative intrac...
- Investigating the Elusive Mechanism of Glycosaminoglycan Biosynthesis
[作者:Victor, XV; Nguyen, TKN; Ethirajan, M; Tran, VM; Nguyen, KV; Kuberan, B,期刊:Journal of Biological Chemistry, 页码:25842-25853 , 文章类型: Article,,卷期:2009年284-38]
- Glycosaminoglycan (GAG) biosynthesis requires numerous biosynthetic enzymes and activated sulfate and sugar donors. Although the sequence of biosynthetic events is resolved using reconstituted systems, little is known ab...
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