- Isodicentric Y Chromosomes and Sex Disorders as Byproducts of Homologous Recombination that Maintains Palindromes
[作者:Lange, J; Skaletsky, H; van Daalen, SKM; Embry, SL; Korver, CM; Brown, LG; Oates, RD; Silber, S; Repping, S; Page, DC,期刊:Cell, 页码:855-869 , 文章类型: Article,,卷期:2009年138-5]
- Massive palindromes in the human Y chromosome harbor mirror-image gene pairs essential for spermatogenesis. During evolution, these gene pairs have been maintained by intrapalindrome, arm-to-arm recombination. The mechan...
- Genome-Organizing Factors Top2 and Hmo1 Prevent Chromosome Fragility at Sites of S phase Transcription
[作者:Bermejo, R; Capra, T; Gonzalez-Huici, V; Fachinetti, D; Cocito, A; Natoli, G; Katou, Y; Mori, H; Kurokawa, K; Shirahige, K; Foiani, M,期刊:Cell, 页码:870-884 , 文章类型: Article,,卷期:2009年138-5]
- Specialized topoisomerases solve the topological constraints arising when replication forks encounter transcription. We have investigated the contribution of Top2 in S phase transcription. Specifically in S phase, Top2 b...
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