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  • Somatic Sex Reprogramming of Adult Ovaries to Testes by FOXL2 Ablation
    [作者:Uhlenhaut, NH; Jakob, S; Anlag, K; Eisenberger, T; Sekido, R; Kress, J; Treier, AC; Klugmann, C; Klasen, C; Holter, NI; Riethmacher, D; Schutz, G; Cooney, AJ; Lovell-Badge, R; Treier, M,期刊:Cell, 页码:1130-1142 , 文章类型: Article,,卷期:2009年139-6]
  • In mammals, the transcription factor SRY, encoded by the Y chromosome, is normally responsible for triggering the indifferent gonads to develop as testes rather than ovaries. However, testis differentiation can occur in ...
  • Platelet Polyphosphates Are Proinflammatory and Procoagulant Mediators In Vivo
    [作者:Muller, F; Mutch, NJ; Schenk, WA; Smith, SA; Esterl, L; Spronk, HM; Schmidbauer, S; Gahl, WA; Morrissey, JH; Renne, T,期刊:Cell, 页码:1143-1156 , 文章类型: Article,,卷期:2009年139-6]
  • Platelets play a central role in thrombosis, hemostasis, and inflammation. We show that activated platelets release inorganic polyphosphate (polyP), a polymer of 60-100 phosphate residues that directly bound to and activ...
  • Reduced IGF-1 Signaling Delays Age-Associated Proteotoxicity in Mice
    [作者:Cohen, E; Paulsson, JF; Blinder, P; Burstyn-Cohen, T; Du, DG; Estepa, G; Adame, A; Pham, HM; Holzenberger, M; Kelly, JW; Masliah, E; Dillin, A,期刊:Cell, 页码:1157-1169 , 文章类型: Article,,卷期:2009年139-6]
  • The insulin/insulin growth factor (IGF) signaling (IIS) pathway is a key regulator of aging of worms, flies, mice, and likely humans. Delayed aging by IIS reduction protects the nematode C. elegans from toxicity associat...
  • Prediction of Photoperiodic Regulators from Quantitative Gene Circuit Models
    [作者:Salazar, JD; Saithong, T; Brown, PE; Foreman, J; Locke, JCW; Halliday, KJ; Carre, IA; Rand, DA; Millar, AJ,期刊:Cell, 页码:1170-1179 , 文章类型: Article,,卷期:2009年139-6]
  • Photoperiod sensors allow physiological adaptation to the changing seasons. The prevalent hypothesis is that day length perception is mediated through coupling of an endogenous rhythm with an external light signal. Suffi...