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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共40条记录   Allogeneic hematopoietic cell transplantation for chronic lymphocytic leukemia: ready for prime time? [作者：Delgado, J; Milligan, DW; Dreger, P,期刊：Blood, 页码：2581-2588 , 文章类型： Review，,卷期：2009年114-13] The development of reduced intensity conditioning regimens has increased the number of patients diagnosed with chronic lymphocytic leukemia that are referred for allogeneic hematopoietic cell transplantation (allo-HCT). ... Detailed analysis of p53 pathway defects in fludarabine-refractory chronic lymphocytic leukemia (CLL): dissecting the contribution of 17p deletion, TP53 mutation, p53-p21 dysfunction, and miR34a in a prospective clinical trial [作者：Zenz, T; Habe, S; Denzel, T; Mohr, J; Winkler, D; Buhler, A; Sarno, A; Groner, S; Mertens, D; Busch, R; Hallek, M; Dohner, H; Stilgenbauer, S,期刊：Blood, 页码：2589-2597 , 文章类型： Article，,卷期：2009年114-13] The prognosis of fludarabine (F)-refractory chronic lymphocytic leukemia (CLL) is very poor, and underlying mechanisms are only partly understood. To assess the contribution of p53 abnormalities to F-refractory CLL, we s... Determining the rise in BCR-ABL RNA that optimally predicts a kinase domain mutation in patients with chronic myeloid leukemia on imatinib [作者：Press, RD; Willis, SG; Laudadio, J; Mauro, MJ; Deininger, MWN,期刊：Blood, 页码：2598-2605 , 文章类型： Article，,卷期：2009年114-13] In imatinib-treated chronic myeloid leukemia (CML), secondary drug resistance is often caused by mutations in the BCR-ABL kinase domain (KD). As alternative therapies are available for imatinib resistance, early identifi... Donor, recipient, and transplant characteristics as risk factors after unrelated donor PBSC transplantation: beneficial effects of higher CD34(+) cell dose [作者：Pulsipher, MA; Chitphakdithai, P; Logan, BR; Leitman, SF; Anderlini, P; Klein, JP; Horowitz, MM; Miller, JP; King, RJ; Confer, DL,期刊：Blood, 页码：2606-2616 , 文章类型： Article，,卷期：2009年114-13] We report outcomes of 932 recipients of unrelated donor peripheral blood stem cell hematopoietic cell transplantation (URD-PBSC HCT) for acute myeloid leukemia, acute lymphoblastic leukemia, chronic myelogenous leukemia,... The importance of bone marrow examination in determining complete response to therapy in patients with multiple myeloma [作者：Chee, CE; Kumar, S; Larson, DR; Kyle, RA; Dispenzieri, A; Gertz, MA; Colby, CL; Rajkumar, SV,期刊：Blood, 页码：2617-2618 , 文章类型： Article，,卷期：2009年114-13] The current definition of complete response in multiple myeloma includes a requirement for a bone marrow (BM) examination showing less than 5% plasma cells in addition to negative serum and urine immunofixation. There ha... Restoration of NET formation by gene therapy in CGD controls aspergillosis [作者：Bianchi, M; Hakkim, A; Brinkmann, V; Siler, U; Seger, RA; Zychlinsky, A; Reichenbach, J,期刊：Blood, 页码：2619-2622 , 文章类型： Article，,卷期：2009年114-13] Chronic granulomatous disease (CGD) patients have impaired nicotinamide adenine dinucleotide phosphate (NADPH) oxidase function, resulting in poor antimicrobial activity of neutrophils, including the inability to generat... Dynamic accumulation of plasmacytoid dendritic cells in lymph nodes is regulated by interferon-beta [作者：Gao, YF; Majchrzak-Kita, B; Fish, EN; Gommerman, JL,期刊：Blood, 页码：2623-2631 , 文章类型： Article，,卷期：2009年114-13] Plasmacytoid dendritic cells (pDCs) represent a major cellular component of our front-line defense against viruses because of their capacity to rapidly secrete type I interferon (IFN)-alpha and -beta after infection. Con... Mesenchymal stromal cells cross-present soluble exogenous antigens as part of their antigen-presenting cell properties [作者：Francois, M; Romieu-Mourez, R; Stock-Martineau, S; Boivin, MN; Bramson, JL; Galipeau, J,期刊：Blood, 页码：2632-2638 , 文章类型： Article，,卷期：2009年114-13] Recent studies involving bone marrow mesenchymal stromal cells (MSCs) demonstrated that interferon (IFN)-gamma stimulation induces major histocompatibility complex (MHC) class II-mediated antigen presentation in MSCs bot... Mast cells counteract regulatory T-cell suppression through interleukin-6 and OX40/OX40L axis toward Th17-cell differentiation [作者：Piconese, S; Gri, G; Tripodo, C; Musio, S; Gorzanelli, A; Frossi, B; Pedotti, R; Pucillo, CE; Colombo, MP,期刊：Blood, 页码：2639-2648 , 文章类型： Article，,卷期：2009年114-13] The development of inflammatory diseases implies inactivation of regulatory T (Treg) cells through mechanisms that still are largely unknown. Here we showed that mast cells (MCs), an early source of inflammatory mediator... Pneumoviruses infect eosinophils and elicit MyD88-dependent release of chemoattractant cytokines and interleukin-6 [作者：Dyer, KD; Percopo, CM; Fischer, ER; Gabryszewski, SJ; Rosenberg, HF,期刊：Blood, 页码：2649-2656 , 文章类型： Article，,卷期：2009年114-13] Eosinophils are recruited to the lung in response to infection with pneumovirus pathogens and have been associated with both the pathophysiologic sequelae of infection and, more recently, with accelerated virus clearance... Minimal requirement for induction of natural cytotoxicity and intersection of activation signals by inhibitory receptors [作者：Bryceson, YT; Ljunggren, HG; Long, EO,期刊：Blood, 页码：2657-2666 , 文章类型： Article，,卷期：2009年114-13] Natural killer (NK) cells provide innate control of infected and neoplastic cells. Multiple receptors have been implicated in natural cytotoxicity, but their individual contribution remains unclear. Here, we studied the ... Preclinical characterization of 1-7F9, a novel human anti-KIR receptor therapeutic antibody that augments natural killer-mediated killing of tumor cells [作者：Romagne, F; Andre, P; Spee, P; Zahn, S; Anfossi, N; Gauthier, L; Capanni, M; Ruggeri, L; Benson, DM; Blaser, BW; Della Chiesa, M; Moretta, A; Vivier, E; Caligiuri, MA; Velardi, A; Wagtmann, N,期刊：Blood, 页码：2667-2677 , 文章类型： Article，,卷期：2009年114-13] Inhibitory-cell killer immunoglobulin-like receptors (KIR) negatively regulate natural killer (NK) cell-mediated killing of HLA class I-expressing tumors. Lack of KIR-HLA class I interactions has been associated with pot... Mer receptor tyrosine kinase is a novel therapeutic target in pediatric B-cell acute lymphoblastic leukemia [作者：Linger, RMA; DeRyckere, D; Brandao, L; Sawczyn, KK; Jacobsen, KM; Liang, XY; Keating, AK; Graham, DK,期刊：Blood, 页码：2678-2687 , 文章类型： Article，,卷期：2009年114-13] Acute lymphoblastic leukemia (ALL) is currently treated with an intense regimen of chemotherapy yielding cure rates near 80%. However, additional changes using available drugs are unlikely to provide significant improvem... Deregulated expression of cytokine receptor gene, CRLF2, is involved in lymphoid transformation in B-cell precursor acute lymphoblastic leukemia [作者：Russell, LJ; Capasso, M; Vater, I; Akasaka, T; Bernard, OA; Calasanz, MJ; Chandrasekaran, T; Chapiro, E; Gesk, S; Griffiths, M; Guttery, DS; Haferlach, C; Harder, L; Heidenreich, O; Irving, J; Kearney, L; Nguyen-Khac, F; Machado, L; Minto, L; Majid, A; Moorman, AV; Morrison, H; Rand, V; Strefford, JC; Schwab, C; Tonnies, H; Dyer, MJS; Siebert, R; Harrison, CJ,期刊：Blood, 页码：2688-2698 , 文章类型： Article，,卷期：2009年114-13] We report 2 novel, cryptic chromosomal abnormalities in precursor B-cell acute lymphoblastic leukemia (BCP-ALL): a translocation, either t(X;14)(p22;q32) or t(Y;14)(p11;q32), in 33 patients and an interstitial deletion, ... Aurora kinase A is a target of Wnt/beta-catenin involved in multiple myeloma disease progression [作者：Dutta-Simmons, J; Zhang, YY; Gorgun, G; Gatt, M; Mani, M; Hideshima, T; Takada, K; Carlson, NE; Carrasco, DE; Tai, YT; Raje, N; Letai, AG; Anderson, KC; Carrasco, DR,期刊：Blood, 页码：2699-2708 , 文章类型： Article，,卷期：2009年114-13] Multiple myeloma (MM) is a cancer of plasma cells with complex molecular characteristics that evolves from monoclonal gammopathy of undetermined significance, a highly prevalent premalignant condition. MM is the second m... Identification of cancer stem cells in a Tax-transgenic (Tax-Tg) mouse model of adult T-cell leukemia/lymphoma [作者：Yamazaki, J; Mizukami, T; Takizawa, K; Kuramitsu, M; Momose, H; Masumi, A; Ami, Y; Hasegawa, H; Hall, WW; Tsujimoto, H; Hamaguchi, I; Yamaguchi, K,期刊：Blood, 页码：2709-2720 , 文章类型： Article，,卷期：2009年114-13] Adult T-cell leukemia/lymphoma (ATL) is a malignant lymphoproliferative disorder caused by HTLV-I infection. In ATL, chemotherapeutic responses are generally poor, which has suggested the existence of chemotherapy-resist...