- Treatment of myelodysplastic syndrome patients with erythropoietin with or without granulocyte colony-stimulating factor: results of a prospective randomized phase 3 trial by the Eastern Cooperative Oncology Group (E1996)
[作者：Greenberg, PL; Sun, ZX; Miller, KB; Bennett, JM; Tallman, MS; Dewald, G; Paietta, E; van der Jagt, R; Houston, J; Thomas, ML; Cella, D; Rowe, JM,期刊：Blood, 页码：2393-2400 , 文章类型： Article，,卷期：2009年114-12]
- This phase 3 prospective randomized trial evaluated the efficacy and long-term safety of erythropoietin (EPO) with or without granulocyte colony-stimulating factor plus supportive care (SC; n = 53) versus SC alone (n = 5...
- Targeted disruption of Zfp36l2, encoding a CCCH tandem zinc finger RNA-binding protein, results in defective hematopoiesis
[作者：Stumpo, DJ; Broxmeyer, HE; Ward, T; Cooper, S; Hangoc, G; Chung, YJ; Shelley, WC; Richfield, EK; Ray, MK; Yoder, MC; Aplan, PD; Blackshear, PJ,期刊：Blood, 页码：2401-2410 , 文章类型： Article，,卷期：2009年114-12]
- Members of the tristetraprolin family of tandem CCCH finger proteins can bind to AU-rich elements in the 3'-untranslated region of mRNAs, leading to their deadenylation and subsequent degradation. Partial deficiency of 1...
- Apolipoprotein-mediated lipid antigen presentation in B cells provides a pathway for innate help by NKT cells
[作者：Allan, LL; Hoefl, K; Zheng, DJ; Chung, BK; Kozak, FK; Tan, RS; den Elzen, P,期刊：Blood, 页码：2411-2416 , 文章类型： Article，,卷期：2009年114-12]
- Natural killer T (NKT) cells are innate-like lymphocytes that recognize lipid antigens and have been shown to enhance B-cell activation and antibody production. B cells typically recruit T-cell help by presenting interna...
- Safety and immunologic effects of IL-15 administration in nonhuman primates
[作者：Berger, C; Berger, M; Hackman, RC; Gough, M; Elliott, C; Jensen, MC; Riddell, SR,期刊：Blood, 页码：2417-2426 , 文章类型： Article，,卷期：2009年114-12]
- The administration of cytokines that modulate endogenous or transferred T-cell immunity could improve current approaches to clinical immunotherapy. Interleukin-2 (IL-2) is used most commonly for this purpose, but causes ...
- Human T-cell leukemia virus type 2 produces a spliced antisense transcript encoding a protein that lacks a classic bZIP domain but still inhibits Tax2-mediated transcription
[作者：Halin, M; Douceron, E; Clerc, I; Journo, C; Ko, NL; Landry, S; Murphy, EL; Gessain, A; Lemasson, I; Mesnard, JM; Barbeau, B; Mahieux, R,期刊：Blood, 页码：2427-2438 , 文章类型： Article，,卷期：2009年114-12]
- Human T-cell leukemia virus type 1 (HTLV-1) and type 2 (HTLV-2) retroviruses infect T lymphocytes. The minus strand of the HTLV-1 genome encodes HBZ, a protein that could play a role in the development of leukemia in inf...
- Factor H-related protein 1 (CFHR-1) inhibits complement C5 convertase activity and terminal complex formation
[作者：Heinen, S; Hartmann, A; Lauer, N; Wiehl, U; Dahse, HM; Schirmer, S; Gropp, K; Enghardt, T; Wallich, R; Halbich, S; Mihlan, M; Schlotzer-Schrehardt, U; Zipfel, PF; Skerka, C,期刊：Blood, 页码：2439-2447 , 文章类型： Article，,卷期：2009年114-12]
- Homozygous deletion of a 84-kb genomic fragment in human chromosome 1 that encompasses the CFHR1 and CFHR3 genes represents a risk factor for hemolytic uremic syndrome (HUS) but has a protective effect in age-related mac...
- The IKK2/NF-kappa B pathway suppresses MYC-induced lymphomagenesis
[作者：Klapproth, K; Sander, S; Marinkovic, D; Baumann, B; Wirth, T,期刊：Blood, 页码：2448-2458 , 文章类型： Article，,卷期：2009年114-12]
- Deregulated c-MYC is found in a variety of cancers where it promotes proliferation as well as apoptosis. In many hematologic malignancies, enhanced NF-kappa B exerts prosurvival functions. Here we investigated the role o...
- Long-term protection from syngeneic acute lymphoblastic leukemia by CpG ODN-mediated stimulation of innate and adaptive immune responses
[作者：Seif, AE; Barrett, DM; Milone, M; Brown, VI; Grupp, SA; Reid, GSD,期刊：Blood, 页码：2459-2466 , 文章类型： Article，,卷期：2009年114-12]
- Acute lymphoblastic leukemia (ALL) is the most common childhood cancer and remains a major cause of mortality in children with recurrent disease and in adults. Despite observed graft-versusleukemia effects after stem cel...
- TNFAIP3/A20 functions as a novel tumor suppressor gene in several subtypes of non-Hodgkin lymphomas
[作者：Honma, K; Tsuzuki, S; Nakagawa, M; Tagawa, H; Nakamura, S; Morishima, Y; Seto, M,期刊：Blood, 页码：2467-2475 , 文章类型： Article，,卷期：2009年114-12]
- The constitutive activation of nuclear factor-kappa B (NF-kappa B) has been implicated in tumorigenesis of lymphoid malignancies. We have previously shown that chromosome 6q was frequently deleted in ocular marginal zone...
- Homing and invasiveness of MLL/ENL leukemic cells is regulated by MEF2C
[作者：Schwieger, M; Schuler, A; Forster, M; Engelmann, A; Arnold, MA; Delwel, R; Valk, PJ; Lohler, J; Slany, RK; Olson, EN; Stocking, C,期刊：Blood, 页码：2476-2488 , 文章类型： Article，,卷期：2009年114-12]
- Acute myelogenous leukemia is driven by leukemic stem cells (LSCs) generated by mutations that confer (or maintain) self-renewal potential coupled to an aberrant differentiation program. Using retroviral mutagenesis, we ...
- Novel prognostic subgroups in childhood 11q23/MLL-rearranged acute myeloid leukemia: results of an international retrospective study
[作者：Balgobind, BV; Raimondi, SC; Harbott, J; Zimmermann, M; Alonzo, TA; Auvrignon, A; Beverloo, HB; Chang, M; Creutzig, U; Dworzak, MN; Forestier, E; Gibson, B; Hasle, H; Harrison, CJ; Heerema, NA; Kaspers, GJL; Leszl, A; Litvinko, N; Lo Nigro, L; Morimoto, A; Perot, C; Pieters, R; Reinhardt, D; Rubnitz, JE; Smith, FO; Stary, J; Stasevich, I; Strehl, S; Taga, T; Tomizawa, D; Webb, D; Zemanova, Z; Zwaan, CM; van den Heuvel-Eibrink, MM,期刊：Blood, 页码：2489-2496 , 文章类型： Article，,卷期：2009年114-12]
- Translocations involving chromosome 11q23 frequently occur in pediatric acute myeloid leukemia (AML) and are associated with poor prognosis. In most cases, the MLL gene is involved, and more than 50 translocation partner...
- Primed innate immunity leads to autoinflammatory disease in PSTPIP2-deficient cmo mice
[作者：Chitu, V; Ferguson, PJ; de Bruijn, R; Schlueter, AJ; Ochoa, LA; Waldschmidt, TJ; Yeung, YG; Stanley, ER,期刊：Blood, 页码：2497-2505 , 文章类型： Article，,卷期：2009年114-12]
- The mouse Lupo (I282N) mutation in proline-serine-threonine phosphatase interacting protein 2 (PSTPIP2) leads to reduced expression of PSTPIP2 that is associated with a macrophage-mediated autoinflammatory disease. Anoth...
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