- Developing Dual and Specific Inhibitors of Dimethylarginine Dimethylaminohydrolase-1 and Nitric Oxide Synthase: Toward a Targeted Polypharmacology To Control Nitric Oxide
[作者:Wang, Y; Monzingo, AF; Hu, SG; Schaller, TH; Robertus, JD; Fast, W,期刊:Biochemistry, 页码:8624-8635 , 文章类型: Article,,卷期:2009年48-36]
- Molecules that block nitric oxide's (NO) biosynthesis are of significant interest. For example, nitric oxide synthase (NOS) inhibitors have been suggested as antitumor therapeutics, as have inhibitors of dimethylarginine...
- Mechanism of Flavin Reduction and Oxidation in the Redox-Sensing Quinone Reductase Lot6p from Saccharomyces cerevisiae
[作者:Sollner, S; Deller, S; Macheroux, P; Palfey, BA,期刊:Biochemistry, 页码:8636-8643 , 文章类型: Article,,卷期:2009年48-36]
- Quinone reductases are flavin-containing enzymes that have been implicated in protecting organisms from redox stress and., more recently, as redox switches controlling the action of the proteasome. The reactions of the c...
- Structure of PqsD, a Pseudomonas Quinolone Signal Biosynthetic Enzyme, in Complex with Anthranilate
[作者:Bera, AK; Atanasova, V; Robinson, H; Eisenstein, E; Coleman, JP; Pesci, EC; Parsons, JF,期刊:Biochemistry, 页码:8644-8655 , 文章类型: Article,,卷期:2009年48-36]
- Pseudomonas quinolone signal (PQS), 2-heptyl-3-hydroxy-4-quinolone, is an intercellular alkyl quinolone signaling molecule produced by the opportunistic pathogen Pseudomonas aeruginosa. Alkyl quinolone signaling is an at...
- Structure and Function of Bacillus subtilis YphP, a Prokaryotic Disulfide Isomerase with a CXC Catalytic Motif
[作者:Derewenda, U; Boczek, T; Gorres, KL; Yu, M; Hung, LW; Cooper, D; Joachimiak, A; Raines, RT; Derewenda, ZS,期刊:Biochemistry, 页码:8664-8671 , 文章类型: Article,,卷期:2009年48-36]
- The DUF1094 family contains over 100 bacterial proteins, all containing a conserved CXC motif, with unknown function. We solved the crystal structure of the Bacillus subtilis representative, the product of the yphP gene....
- Crystal Structure and Acyl Chain Selectivity of Escherichia coli LpxD, the N-Acyltransferase of Lipid A Biosynthesis
[作者:Bartling, CM; Raetz, CRH,期刊:Biochemistry, 页码:8672-8683 , 文章类型: Article,,卷期:2009年48-36]
- LpxD catalyzes the third step of lipid A biosynthesis, the R-3-hydroxyacyl-ACP-dependent N-acylation of UDP-3-O-(acyl)-alpha-D-glucosamine, and is a target for new antibiotic development, Here we report the 2.6 angstrom ...
- A C-Terminal Lobe of the beta Subunit of Na,K-ATPase and H,K-ATPase Resembles Cell Adhesion Molecules
[作者:Bab-Dinitz, E; Albeck, S; Peleg, Y; Brumfeld, V; Gottschalk, KE; Karlish, SJD,期刊:Biochemistry, 页码:8684-8691 , 文章类型: Article,,卷期:2009年48-36]
- The beta subunit of Na,K-ATPase is required for stabilization and maturation of the catalytic alpha subunits and is also involved in cell adhesion and establishing epithelial cell polarity. However, the mechanism of cell...
- Mapping the Interaction of Pro-Apoptotic tBID with Pro-Survival BCL-XL
[作者:Yao, Y; Bobkov, AA; Plesniak, LA; Marassi, FM,期刊:Biochemistry, 页码:8704-8711 , 文章类型: Article,,卷期:2009年48-36]
- The BH3-only BCL-2 family protein BID is activated by caspase-8 cleavage upon engagement of cell surface death receptors. The resulting 15 kDa C-terminal fragment, tBID, translocates to mitochondria, triggering the relea...
- Thermodynamic Characterization of the Folding Equilibrium of the Human Nedd4-WW4 Domain: At the Frontiers of Cooperative Folding
[作者:Cobos, ES; Iglesias-Bexiga, M; Ruiz-Sanz, J; Mateo, PL; Luque, I; Martinez, JC,期刊:Biochemistry, 页码:8712-8720 , 文章类型: Article,,卷期:2009年48-36]
- WW domains are the smallest naturally independent beta-sheet protein structures available to date and constitute attractive model systems for investigating the determinants of beta-sheet folding and stability. Nonetheles...
- Kinetic and Structural Investigations of the Allosteric Site in Human Epithelial 15-Lipoxygenase-2
[作者:Wecksler, AT; Kenyon, V; Garcia, NK; Deschamps, JD; van der Donk, WA; Holman, TR,期刊:Biochemistry, 页码:8721-8730 , 文章类型: Article,,卷期:2009年48-36]
- Allosteric regulation of human lipoxygenase (hLO) activity has recently been implicated in the cellular biology of prostate cancer. In the current work, we present isotope effect, pH, and substrate inhibitor data of epit...
- Interactions between Large and Small Subunits of Different Acetohydroxyacid Synthase Isozymes of Esherichia coli
[作者:Vyazmensky, M; Zherdev, Y; Slutzker, A; Belenky, I; Kryukov, O; Barak, Z; Chipman, DM,期刊:Biochemistry, 页码:8731-8737 , 文章类型: Article,,卷期:2009年48-36]
- The large, catalytic subunits (LSUs; ilvB, ilvG and ilvI, respectively) of enterobacterial acetohydroxyacid synthases isozymes (AHAS I, II and III) have molecular weights similar to 60 kDa and are paralogous with a famil...
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