- M-3 Muscarinic Receptors Mediate Positive Inotropic Responses in Mouse Atria: A Study with Muscarinic Receptor Knockout Mice
[作者:Kitazawa, T; Asakawa, K; Nakamura, T; Teraoka, H; Unno, T; Komori, S; Yamada, M; Wess, J,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:487-493 , 文章类型: Article,,卷期:2009年330-2]
- The potential functional roles of M-3 muscarinic receptors in mouse atria were examined by pharmacological and molecular biological techniques, using wild-type mice, muscarinic M-2 or M-3 receptor single knockout (M2KO, ...
- Full and Partial Agonists of Muscarinic M-3 Receptors Reveal Single and Oscillatory Ca2+ Responses by beta(2)-Adrenoceptors
[作者:Kurian, N; Hall, CJ; Wilkinson, GF; Sullivan, M; Tobin, AB; Willars, GB,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:502-512 , 文章类型: Article,,卷期:2009年330-2]
- Under physiological circumstances, cellular responses often reflect integration of signaling by two or more different receptors activated coincidentally or sequentially. In addition to heterologous desensitization, there...
- Convection-Enhanced Drug Delivery of Interleukin-4 Pseudomonas Exotoxin (PRX321): Increased Distribution and Magnetic Resonance Monitoring
[作者:Mardor, Y; Last, D; Daniels, D; Shneor, R; Maier, SE; Nass, D; Ram, Z,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:520-525 , 文章类型: Article,,卷期:2009年330-2]
- Convection-enhanced drug delivery (CED) enables achieving a drug concentration within brain tissue and brain tumors that is orders of magnitude higher than by systemic administration. Previous phase I/II clinical trials ...
- The Late Na+ Current (I-Na) Inhibitor Ranolazine Attenuates Effects of Palmitoyl-L-Carnitine to Increase Late I-Na and Cause Ventricular Diastolic Dysfunction
[作者:Wu, YZ; Song, YJ; Belardinelli, L; Shryock, JC,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:550-557 , 文章类型: Article,,卷期:2009年330-2]
Palmitoyl-L-carnitine (PC), an ischemic metabolite, causes cellular Na+ and Ca2+ overload and cardiac dysfunction. This study determined whether ranolazine [(+/-)-1-piperazineacetamide, N-(2,6-dimethylphenyl)-4-[2-hyd...
- Topiramate Reduces Excitability in the Basolateral Amygdala by Selectively Inhibiting GluK1 (GluR5) Kainate Receptors on Interneurons and Positively Modulating GABA(A) Receptors on Principal Neurons
[作者:Braga, MFM; Aroniadou-Anderjaska, V; Li, H; Rogawski, MA,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:558-566 , 文章类型: Article,,卷期:2009年330-2]
- Topiramate [2,3:4,5-bis-O-(1-methylethylidene)-beta-D-fructopyranosesulfamate] is a structurally novel antiepileptic drug that has broad efficacy in epilepsy, but the mechanisms underlying its therapeutic activity are no...
- T-Cell Receptor-Stimulated Calcineurin Activity Is Inhibited in Isolated T Cells from Transplant Patients
[作者:Tumlin, JA; Roberts, BR; Kokko, KE; El Minshawy, O; Gooch, JL,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:602-607 , 文章类型: Article,,卷期:2009年330-2]
- The addition of calcineurin inhibitors, including cyclosporine A (CsA) and FK-506 (tacrolimus), to transplant protocols has markedly reduced acute allograft rejection and prolonged patient survival. Although monitoring o...
- Clodronate-Induced Cell Apoptosis in Human Thyroid Carcinoma Is Mediated via the P2 Receptor Signaling Pathway
[作者:Yang, DM; Teng, HC; Chen, KH; Tsai, ML; Lee, TK; Chou, YC; Chi, CW; Chiou, SH; Lee, CH,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:613-623 , 文章类型: Article,,卷期:2009年330-2]
Clodronate, a halogenated bisphosphonate, can inhibit the growth of human thyroid carcinoma (TC) cells. Previously, we found that a clodronate-induced Ca2+ transient was correlated with clodronate-induced growth inhib...
- Preclinical Evaluation of Long-Acting Muscarinic Antagonists: Comparison of Tiotropium and Investigational Drugs
[作者:Casarosa, P; Bouyssou, T; Germeyer, S; Schnapp, A; Gantner, F; Pieper, M,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:660-668 , 文章类型: Article,,卷期:2009年330-2]
- Chronic obstructive pulmonary disease (COPD) is characterized by progressive airflow limitation caused by persistent inflammatory processes in the airways. An increased cholinergic tone mediates different pathophysiologi...
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