- Synthesis and pharmacological evaluation of N-phenyl-acetamide sulfonamides designed as novel non-hepatotoxic analgesic candidates
[作者:Barbosa, MLD; Melo, GMD; da Silva, YKC; Lopes, RD; de Souza, ET; de Queiroz, AC; Smaniotto, S; Alexandre-Moreira, MS; Barreiro, EJ; Lima, LM,期刊:European Journal of Medicinal Chemistry, 页码:3612-3620 , 文章类型: Article,,卷期:2009年44-9]
- In this paper we report the design, synthesis and pharmacological evaluation of a series of N-phenyl-acetamide sulfonamide derivatives (5a-g), planned by structural modification on the prototype paracetamol (1). In this ...
- Synthesis and anti-osteoporotic evaluation of certain 3-amino-2-hydroxypropoxyisoflavone derivatives
[作者:Tseng, CH; Chen, YL; Lu, CM; Wang, CK; Tsai, YT; Lin, RW; Chen, CF; Chang, YF; Wang, GJ; Ho, ML; Tzeng, CC,期刊:European Journal of Medicinal Chemistry, 页码:3621-3626 , 文章类型: Article,,卷期:2009年44-9]
- We report herein the synthesis and anti-osteoporotic evaluation of certain 3-amino-2-hydroxypropoxyisoflavone derivatives. The results indicated that 3-(3,4-dimethoxyphenyl)-7-(oxiran-2-ylmethoxy)-4H-chromen-4-one (4) an...
- Synthesis and in vitro anticancer activity of 2,4-azolidinedione-acetic acids derivatives
[作者:Kaminskyy, D; Zimenkovsky, B; Lesyk, R,期刊:European Journal of Medicinal Chemistry, 页码:3627-3636 , 文章类型: Article,,卷期:2009年44-9]
- The synthesis and evaluation of anticancer activity of 2,4-thia(imida)zolidinedione-3- and 5-acetic acids amides were described. The structures of compounds were determined by IR, H-1 NMR, and MS analysis. In vitro antic...
- Synthesis and pharmacological investigation of 3-(substituted 1-phenylethanone)-4-(substituted phenyl)-1, 2, 3, 4-tetrahydropyrimidine-5-carboxylates
[作者:Chikhale, RV; Bhole, RP; Khedekar, PB; Bhusari, KP,期刊:European Journal of Medicinal Chemistry, 页码:3645-3653 , 文章类型: Article,,卷期:2009年44-9]
- Fifteen new ethyl 6-methyl-2-methoxy-3-(substituted 1-phenylethanone)4-(substituted phenyl)-1, 2, 3, 4-tetrahydropyrimidine-5-carboxylates (6a-o) have been synthesized in a two step reaction. In first step ethyl acetoace...
- Synthesis and anticonvulsant activity of N-(2-hydroxyethyl) cinnamamide derivatives
[作者:Guan, LP; Wei, CX; Deng, XQ; Sui, X; Piao, HR; Quan, ZS,期刊:European Journal of Medicinal Chemistry, 页码:3654-3657 , 文章类型: Article,,卷期:2009年44-9]
- A series of novel N-(2-hydroxyethyl) cinnamamide derivatives were synthesized and screened for their anticonvulsant activities by the maximal electroshock (MES) test and their neurotoxicity was evaluated by the rotarod n...
- Development of QSAR models for predicting hepatocarcinogenic toxicity of chemicals
[作者:Massarelli, I; Imbriani, M; Coi, A; Saraceno, M; Carli, N; Bianucci, AM,期刊:European Journal of Medicinal Chemistry, 页码:3658-3664 , 文章类型: Article,,卷期:2009年44-9]
- A dataset comprising 55 chemicals with hepatocarcinogenic potency indices was collected from the Carcinogenic Potency Database with the aim of developing QSAR models enabling prediction of the above unwanted property for...
- Synthesis and anticonvulsant activity of some new bishydrazones derived from 3,4-dipropyloxythiophene
[作者:Kulandasamy, R; Adhikari, AV; Stables, JP,期刊:European Journal of Medicinal Chemistry, 页码:3672-3679 , 文章类型: Article,,卷期:2009年44-9]
- A series of new 3,4-dipropyloxy-N-2,N-5-bis(substituted)thiophene-2,5-dicarbohydrazides (4-30) were synthesized from ethyl thiodiglycolate and diethyloxalate through multistep reactions. Following Dieckmann-Komppa reacti...
- Synthesis of new acridines and hydrazones derived from cyclic beta-diketone for cytotoxic and antiviral evaluation
[作者:El-Sabbagh, OI; Rady, HM,期刊:European Journal of Medicinal Chemistry, 页码:3680-3686 , 文章类型: Article,,卷期:2009年44-9]
- Cyclic beta-diketone namely, dimedone was utilized to prepare different chemical entities whether cyclic such as acridines, thiadiazole and triazole or acyclic systems as hydrazide, hydrazones, thiosemicarbazide and semi...
- Regioselective reaction: Synthesis and pharmacological study of Mannich bases containing ibuprofen moiety
[作者:Sujith, KV; Rao, JN; Shetty, P; Kalluraya, B,期刊:European Journal of Medicinal Chemistry, 页码:3697-3702 , 文章类型: Article,,卷期:2009年44-9]
- A series of 4-[(4-aryl)methylidene]amino-2-(substituted4-ylmethyl)-5-{1-[4-(2-methylpropyl)phenyl]ethyl}-2,4-dihydro-3H-1,2,4-triazole-3-thione (6) were synthesized from an arylpropionic acid namely, ibuprofen by a three...
- Application of 3D QSAR CoMFA/CoMSIA and in silico docking studies on novel renin inhibitors against cardiovascular diseases
[作者:Politi, A; Durdagi, S; Moutevelis-Minakakis, P; Kokotos, G; Papadopoulos, MG; Mavromoustakos, T,期刊:European Journal of Medicinal Chemistry, 页码:3703-3711 , 文章类型: Article,,卷期:2009年44-9]
- For the first time, a set of renin inhibitors were subjected to the 3D QSAR/CoMFA and CoMSIA studies. The utility of renin inhibitors in the treatment of cardiovascular diseases has not been fully explored yet. At the mo...
- Determination of permeability and lipophilicity of pyrazolo-pyrimidine tyrosine kinase inhibitors and correlation with biological data
[作者:Dreassi, E; Zizzari, AT; Falchi, F; Schenone, S; Santucci, A; Maga, G; Botta, M,期刊:European Journal of Medicinal Chemistry, 页码:3712-3717 , 文章类型: Article,,卷期:2009年44-9]
- A library of 23 pyrazolo-pyrimidine compounds Src tyrosine kinase (TK) inhibitors, that reduced proliferation of a human osteogenic sarcoma cell line, was taken to investigate lack of correlation between inhibition of ce...
- Synthesis and immunosuppressive activity of cyclolinopeptide A analogues containing homophenylalanine
[作者:Drygala, P; Olejnik, J; Mazur, A; Kierus, K; Jankowski, S; Zimecki, M; Zabrocki, J,期刊:European Journal of Medicinal Chemistry, 页码:3731-3738 , 文章类型: Article,,卷期:2009年44-9]
- Immune response suppressors are used in the medical praxis to prevent graft rejection after organ transplantation and in the therapy of some autoimmune diseases. Cyclolinopeptide A, naturally existing immunomodulatory pe...
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