- An Rtt109-Independent Role for Vps75 in Transcription-Associated Nucleosome Dynamics
[作者:Selth, LA; Lorch, Y; Ocampo-Hafalla, MT; Mitter, R; Shales, M; Krogan, NJ; Kornberg, RD; Svejstrup, JQ,期刊:Molecular and Cellular Biology, 页码:4220-4234 , 文章类型: Article,,卷期:2009年29-15]
- The histone chaperone Vps75 forms a complex with, and stimulates the activity of, the histone acetyltransferase Rtt109. However, Vps75 can also be isolated on its own and might therefore possess Rtt109-independent functi...
- Loss of the Tumor Suppressor Gene NF2, Encoding Merlin, Constitutively Activates Integrin-Dependent mTORC1 Signaling
[作者:Lopez-Lago, MA; Okada, T; Murillo, MM; Socci, N; Giancotti, FG,期刊:Molecular and Cellular Biology, 页码:4235-4249 , 文章类型: Article,,卷期:2009年29-15]
- Integrin signaling promotes, through p21-activated kinase, phosphorylation and inactivation of the tumor suppressor merlin, thus removing a block to mitogenesis in normal cells. However, the biochemical function of merli...
- NF2/Merlin Is a Novel Negative Regulator of mTOR Complex 1, and Activation of mTORC1 Is Associated with Meningioma and Schwannoma Growth
[作者:James, MF; Han, S; Polizzano, C; Plotkin, SR; Manning, BD; Stemmer-Rachamimov, AO; Gusella, JF; Ramesh, V,期刊:Molecular and Cellular Biology, 页码:4250-4261 , 文章类型: Article,,卷期:2009年29-15]
- Inactivating mutations of the neurofibromatosis 2 (NF2) gene, NF2, result predominantly in benign neurological tumors, schwannomas and meningiomas, in humans; however, mutations in murine Nf2 lead to a broad spectrum of ...
- Human Dna2 Is a Nuclear and Mitochondrial DNA Maintenance Protein
[作者:Duxin, JP; Dao, B; Martinsson, P; Rajala, N; Guittat, L; Campbell, JL; Spelbrink, JN; Stewart, SA,期刊:Molecular and Cellular Biology, 页码:4274-4282 , 文章类型: Article,,卷期:2009年29-15]
- Dna2 is a highly conserved helicase/nuclease that in yeast participates in Okazaki fragment processing, DNA repair, and telomere maintenance. Here, we investigated the biological function of human Dna2 (hDna2). Immunoflu...
- Phosphorylation of Eukaryotic Translation Initiation Factor 2 alpha Coordinates rRNA Transcription and Translation Inhibition during Endoplasmic Reticulum Stress
[作者:DuRose, JB; Scheuner, D; Kaufman, RJ; Rothblum, LI; Niwa, M,期刊:Molecular and Cellular Biology, 页码:4295-4307 , 文章类型: Article,,卷期:2009年29-15]
- The endoplasmic reticulum (ER) is the major cellular compartment where folding and maturation of secretory and membrane proteins take place. When protein folding needs exceed the capacity of the ER, the unfolded protein ...
- Site-Specific mTOR Phosphorylation Promotes mTORC1-Mediated Signaling and Cell Growth
[作者:Acosta-Jaquez, HA; Keller, JA; Foster, KG; Ekim, B; Soliman, GA; Feener, EP; Ballif, BA; Fingar, DC,期刊:Molecular and Cellular Biology, 页码:4308-4324 , 文章类型: Article,,卷期:2009年29-15]
- The mammalian target of rapamycin (mTOR) complex 1 (mTORC1) functions as a rapamycin-sensitive environmental sensor that promotes cellular biosynthetic processes in response to growth factors and nutrients. While diverse...
- Defective Histone Acetylation Is Responsible for the Diminished Expression of Cyclooxygenase 2 in Idiopathic Pulmonary Fibrosis
[作者:Coward, WR; Watts, K; Feghali-Bostwick, CA; Knox, A; Pang, LH,期刊:Molecular and Cellular Biology, 页码:4325-4339 , 文章类型: Article,,卷期:2009年29-15]
- Diminished cyclooxygenase 2 (COX-2) expression in fibroblasts, with a resultant defect in the production of the antifibrotic mediator prostaglandin E2, plays a key role in the pathogenesis of idiopathic pulmonary fibrosi...
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