- Randomized, Double-Blind, Phase 2a Trial of Falciparum Malaria Vaccines RTS,S/AS01B and RTS,S/AS02A in Malaria-Naive Adults: Safety, Efficacy, and Immunologic Associates of Protection
[作者:Kester, KE; Cummings, JF; Ofori-Anyinam, O; Ockenhouse, CF; Krzych, U; Moris, P; Schwenk, R; Nielsen, RA; Debebe, Z; Pinelis, E; Juompan, L; Williams, J; Dowler, M; Stewart, VA; Wirtz, RA; Dubois, MC; Lievens, M; Cohen, J; Ballou, WR; Heppner, DG,期刊:Journal of Infectious Diseases, 页码:337-346 , 文章类型: Article,,卷期:2009年200-3]
- Background. To further increase the efficacy of malaria vaccine RTS,S/AS02A, we tested the RTS, S antigen formulated using the AS01B Adjuvant System (GlaxoSmithKline Biologicals).Methods. In a double-blind, randomized tr...
- Analysis of Plasmodium falciparum var Genes Expressed in Children from Papua New Guinea
[作者:Falk, N; Kaestli, M; Qi, WH; Ott, M; Baea, K; Cortes, A; Beck, HP,期刊:Journal of Infectious Diseases, 页码:347-356 , 文章类型: Article,,卷期:2009年200-3]
- Background. The variable antigen P. falciparum erythrocyte membrane protein-1 (PfEMP1) is a major virulence factor in malaria. A large number of var genes encode PfEMP1, and we hypothesized that a restricted PfEMP1 reper...
- Highly Effective Oral Amphotericin B Formulation against Murine Visceral Leishmaniasis
[作者:Wasan, KM; Wasan, EK; Gershkovich, P; Zhu, XH; Tidwell, RR; Werbovetz, KA; Clement, JG; Thornton, SJ,期刊:Journal of Infectious Diseases, 页码:357-360 , 文章类型: Article,,卷期:2009年200-3]
- Visceral leishmaniasis is a deadly parasitic disease caused by obligate intramacrophage protozoans of the Leishmania genus. The World Health Organization estimates the annual death toll to be 50,000, with 500,000 new cas...
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