- Ribavirin Acts via Multiple Pathways in Inhibition of Leukemic Cell Proliferation
[作者:Kokeny, S; Papp, J; Weber, G; Vaszko, T; Carmona-Saez, P; Olah, E,期刊:Anticancer Research, 页码:1971-1980 , 文章类型: Article,,卷期:2009年29-6]
- The aim of this study was to elucidate the anticancer activity of Ribavirin, an antiviral drug and a known inhibitor of inositide-5'-monophosphate dehydrogenase. Materials and Methods: Using human cancer cell lines, the ...
- Promoted Cell Proliferation by Connexin 30 Gene Transfection to Head-and-Neck Cancer Cell Line
[作者:Ozawa, H; Mutai, H; Matsunaga, T; Tokumaru, Y; Fujii, M; Sakamoto, K; Tomita, T; Ogawa, K,期刊:Anticancer Research, 页码:1981-1985 , 文章类型: Article,,卷期:2009年29-6]
- Background: There have been inconsistent results regarding the contribution of the connexin family of genes to tumor cell proliferation. Materials and Methods: We aimed to clarify the role of connexin 30 (Cx30), by trans...
- Assessment of Erlotinib in Chemoresponse Assay
[作者:Rice, SD; Bush, JE; Brower, SL,期刊:Anticancer Research, 页码:1993-1997 , 文章类型: Article,,卷期:2009年29-6]
- Background: There is a need to identify the subset of patients sensitive to epidermal growth factor receptor (EGFR) inhibition prior to using such treatments. Materials and Methods: Three non-small cell lung cancer (NSCL...
- Prioritization of EGFR/IGF-IR/VEGFR2 Combination Targeted Therapies Utilizing Cancer Models
[作者:Tonra, JR; Corcoran, E; Deevi, DS; Steiner, P; Kearney, J; Li, HL; Ludwig, DL; Zhu, ZP; Witte, L; Surguladze, D; Hicklin, DJ,期刊:Anticancer Research, 页码:1999-2007 , 文章类型: Article,,卷期:2009年29-6]
- Background: Rational strategies utilizing anticancer efficacy and biological principles are needed for the prioritization of specific combination targeted therapy approaches for clinical development, from among the many ...
- 14-3-3 sigma-Dependent Resistance to Cisplatin
[作者:Han, ZY; Dimas, K; Tian, XF; Wang, YB; Hemmi, H; Yamada, K; Kato, N; Pantazi, P; Ramanujam, RJ; Anant, S; Wyche, JH; Houchen, CW,期刊:Anticancer Research, 页码:2009-2014 , 文章类型: Article,,卷期:2009年29-6]
- Background: A major factor that impedes the clinical success of cisplatin-based chemotherapy for cancer is cisplatin resistance by cancer cells. Materials and Methods: The sensitivity of parental HCT116 human colon cance...
- Overexpression of Adenovirus-mediated p27(kip1) Lacking the Jab1-binding Region Enhances Cytotoxicity and Inhibits Xenografted Human Cholangiocarcinoma Growth
[作者:Shiraso, S; Katayose, Y; Yamamoto, K; Mizuma, M; Yabuuchi, S; Oda, A; Rikiyama, T; Onogawa, T; Yoshida, H; Hayashi, H; Ohtsuka, H; Motoi, F; Egawa, S; Kato, J; Unno, M,期刊:Anticancer Research, 页码:2015-2024 , 文章类型: Article,,卷期:2009年29-6]
- The cyclin-dependent kinase inhibitor (CDK1) p27(kip1) is a negative regulator of cell cycling and has antitumor effects. In our previous study, the recombinant adenovirus expressing wild-type p27(kip1) (Adp27-wt) induce...
- Promoter Demethylation of WIF-1 by Epigallocatechin-3-gallate in Lung Cancer Cells
[作者:Gao, Z; Xu, ZD; Hung, MS; Lin, YC; Wang, TY; Gong, M; Zhi, XY; Jablon, DM; You, L,期刊:Anticancer Research, 页码:2025-2030 , 文章类型: Article,,卷期:2009年29-6]
- Background: Aberrant promoter methylation of Writ inhibitory factor-1 (WIF-1) is a fundamental mechanism of epigenetic silencing in human cancers. Epigallocatechin-3-gallate (EGCG) has been reported to directly reactivat...
- Decreased Levels of Both Stat1 and Stat3 in T Lymphocytes from Mice Bearing Mammary Tumors
[作者:Handel-Fernandez, ME; Ilkovitch, D; Iragavarapu-Charyulu, V; Herbert, LM; Lopez, DM,期刊:Anticancer Research, 页码:2051-2058 , 文章类型: Article,,卷期:2009年29-6]
- Background: Lymphocytes from tumor-bearing animals have been shown to lack antitumor function. The objective of this study was to investigate the status of the signal transducers, Stat1 and Stat3, in T lymphocytes of ani...
- Chemopreventive Effect of 4-[3,5-Bis(trimethylsilyl)benzamido] Benzoic Acid (TAC-101) on MNU-induced Colon Carcinogenesis in a Rat Model
[作者:Nakayama, Y; Inoue, Y; Minagawa, N; Onitsuka, K; Nagata, J; Shibao, K; Hirata, K; Sako, T; Nagata, N; Yamaguchi, K,期刊:Anticancer Research, 页码:2059-2065 , 文章类型: Article,,卷期:2009年29-6]
- Purpose: 4-[3,5-Bis(trimethylsilyl)benzamido] benzoic acid (TAC-101) is a novel retinobenzoic acid derivative. The chemopreventive effect and the mechanism of action of TAC-101 were investigated using a rat chemical colo...
- In Vitro and In Vivo Effects of CpG-Oligodeoxynucleotides (CpG-ODN) on Murine Transitional Cell Carcinoma and on the Native Murine Urinary Bladder Wall
[作者:Olbert, PJ; Schrader, AJ; Simon, C; Dalpke, A; Barth, P; Hofmann, R; Hegele, A,期刊:Anticancer Research, 页码:2067-2076 , 文章类型: Article,,卷期:2009年29-6]
- Background: Intravesical BCG instillation is established and efficient in the prophylaxis of recurrent transitional cell carcinoma. A Th-1 biased immune response is postulated. Recent work has proven the efficacy of synt...
- Cytoplasmic Accumulation of Glycogen Synthase Kinase-3 beta Is Associated with Aggressive Clinicopathological Features in Human Prostate Cancer
[作者:Li, R; Erdamar, S; Dai, H; Sayeeduddin, M; Frolov, A; Wheeler, TM; Ayala, GE,期刊:Anticancer Research, 页码:2077-2081 , 文章类型: Article,,卷期:2009年29-6]
- Background: Activation of glycogen synthase kinase-3 (GSK-3) is involved in the regulation of cell growth, differentiation, mobility, proliferation and survival. However, its clinicopathologic significance remains unclea...
- Latrunculin A Has a Strong Anticancer Effect in a Peritoneal Dissemination Model of Human Gastric Cancer in Mice
[作者:Konishi, H; Kikuchi, S; Ochiai, T; Ikoma, H; Kubota, T; Ichikawa, D; Fujiwara, H; Okamoto, K; Sakakura, C; Sonoyama, T; Kokuba, Y; Sasaki, H; Matsui, T; Otsuji, E,期刊:Anticancer Research, 页码:2091-2097 , 文章类型: Article,,卷期:2009年29-6]
- Peritoneal dissemination of gastric cancer is a refractory disease. This paper focuses on the efficacy of actin-binding marine macrolide latrunculin A, which quickly inhibits actin polymerization and disrupts the functio...
- An Orally Active Small Molecule TGF-beta Receptor I Antagonist Inhibits the Growth of Metastatic Murine Breast Cancer
[作者:Rausch, MP; Hahn, T; Ramanathapuram, L; Bradley-Dunlop, D; Mahadevan, D; Mercado-Pimentel, ME; Runyan, RB; Besselsen, DG; Zhang, XM; Cheung, HK; Lee, WC; Ling, LE; Akporiaye, ET,期刊:Anticancer Research, 页码:2099-2109 , 文章类型: Article,,卷期:2009年29-6]
- Background: Transforming growth-factor P (TGF-beta) plays a complex role in breast carcinogenesis. Initially functioning as a tumor suppressor, this cytokine later contributes to the progression of malignant cells by enh...
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