- Renal Gene and Protein Expression Signatures for Prediction of Kidney Disease Progression
[作者：Ju, WJ; Eichinger, F; Bitzer, M; Oh, J; McWeeney, S; Berthier, CC; Shedden, K; Cohen, CD; Henger, A; Krick, S; Kopp, JB; Stoeckert, CJ; Dikman, S; Schroppel, B; Thomas, DB; Schlondorff, D; Kretzler, M; Bottinger, EP,期刊：American Journal of Pathology, 页码：2073-2085 , 文章类型： Article，,卷期：2009年174-6]
- Although chronic kidney disease (CKD) is common, only a fraction of CKD patients progress to end-stage renal disease. Molecular predictors to stratify CKD populations according to their risk of progression remain undisco...
- Soluble Epoxide Inhibition Is Protective Against Cerebral Ischemia via Vascular and Neural Protection
[作者：Simpkins, AN; Rudic, RD; Schreihofer, DA; Roy, S; Manhiani, M; Tsai, HJ; Hammock, BD; Imig, JD,期刊：American Journal of Pathology, 页码：2086-2095 , 文章类型： Article，,卷期：2009年174-6]
- Inhibition of soluble epoxide hydrolase (SEH), the enzyme responsible for degradation of vasoactive epoxides, protects against cerebral ischemia in rats. However, the molecular and biological mechanisms that confer prote...
- Activation of the Endoplasmic Reticulum Stress-Associated Transcription Factor X Box-Binding Protein-1 Occurs in a Subset of Normal Germinal-Center B Cells and in Aggressive B-Cell Lymphomas with Prognostic Implications
[作者：Balague, O; Mozos, A; Martinez, D; Hernandez, L; Colomo, L; Mate, JL; Teruya-Feldstein, J; Lin, O; Campo, E; Lopez-Guillermo, A; Martinez, A,期刊：American Journal of Pathology, 页码：2337-2346 , 文章类型： Article，,卷期：2009年174-6]
- X box-binding protein 1 (Xbp-1) is a transcription factor that is required for the terminal differentiation of B lymphocytes into plasma cells. The Xbp-1 gene is activated in response to endoplasmic reticulum stress sign...
- Coordinate Expression of Colony-Stimulating Factor-1 and Colony-Stimulating Factor-1-Related Proteins Is Associated with Poor Prognosis in Gynecological and Nongynecological Leiomyosarcoma
[作者：Espinosa, I; Beck, AH; Lee, CH; Zhu, S; Montgomery, KD; Marinelli, RJ; Ganjoo, KN; Nielsen, TO; Gilks, CB; West, RB; van de Rijn, M,期刊：American Journal of Pathology, 页码：2347-2356 , 文章类型： Article，,卷期：2009年174-6]
- previously, we showed that the presence of high numbers of macrophages correlates with poor prognosis in nongynecological leiomyosarcoma ill In gynecological LMS, a similar trend was noted but did not reach statistical s...
- Erbb2 Suppresses DNA Damage-Induced Checkpoint Activation and UV-Induced Mouse Skin Tumorigenesis
[作者：Madson, JG; Lynch, DT; Svoboda, J; Ophardt, R; Yanagida, J; Putta, SK; Bowles, A; Trempus, CS; Tennant, RW; Hansen, LA,期刊：American Journal of Pathology, 页码：2357-2366 , 文章类型： Article，,卷期：2009年174-6]
- The Erbb2 receptor is activated by UV irradiation, the primary cause of non-melanoma skin cancer. We hypothesized that Erbb2 activation contributes to UV-induced skin tumorigenesis by suppressing cell cycle arrest. Consi...
- The Role of BRAF Mutation and p53 Inactivation during Transformation of a Subpopulation of Primary Human Melanocytes
[作者：Yu, H; McDaid, R; Lee, J; Possik, P; Li, L; Kumar, SM; Elder, DE; Van Belle, P; Gimotty, P; Guerra, M; Hammond, R; Nathanson, KL; Palma, MD; Herlyn, M; Xu, XW,期刊：American Journal of Pathology, 页码：2367-2377 , 文章类型： Article，,卷期：2009年174-6]
- Melanocytic nevi frequently harbor oncogenic BRAF mutations, but only a minority progress to melanoma. in human melanocytes, persistent BRAF(V600E) expression triggers oncogene-induced senescence, which implies that bypa...
- Urinary Excretion of Liver Type Fatty Acid Binding Protein Accurately Reflects the Degree of Tubulointerstitial Damage
[作者：Yokoyama, T; Kamijo-Ikemori, A; Sugaya, T; Hoshino, S; Yasuda, T; Kimura, K,期刊：American Journal of Pathology, 页码：2096-2106 , 文章类型： Article，,卷期：2009年174-6]
- To investigate the relationship between liver-type fatty acid-binding protein (L-FABP), a biomarker of chronic kidney disease, in the kidney and the degree of tubulointerstitial damage, folic acid (FA)-induced nephropath...
- Requirement of the Akt/beta-Catenin Pathway for Uterine Carcinosarcoma Genesis, Modulating E-Cadherin Expression Through the Transactivation of Slug
[作者：Saegusa, M; Hashimura, M; Kuwata, T; Okayasu, I,期刊：American Journal of Pathology, 页码：2107-2115 , 文章类型： Article，,卷期：2009年174-6]
- Uterine carcinosarcomas (UCSs) are considered to represent true examples of the epithelial-mesenchymal transition. Akt plays a key role in the induction of epithelial-mesenchymal transition, but little is known about its...
- alpha 5 beta 1 Integrin Blockade Inhibits Lymphangiogenesis in Airway Inflammation
[作者：Okazaki, T; Ni, A; Ayeni, OA; Baluk, P; Yao, LC; Vossmeyer, D; Zischinsky, G; Zahn, G; Knolle, J; Christner, C; McDonald, DM,期刊：American Journal of Pathology, 页码：2378-2387 , 文章类型： Article，,卷期：2009年174-6]
- The integrin alpha 5 beta 1 has been previously implicated in tumor angiogenesis, but its role in the remodeling of both blood vessels and lymphatics during inflammation is at an early stage of understanding. We examined...
- Capillary Defects and Exaggerated Inflammatory Response in the Airways of EphA2-Deficient Mice
[作者：Okazaki, T; Ni, A; Baluk, P; Ayei, OA; Kearley, J; Coyle, AJ; Humbles, A; McDonald, DM,期刊：American Journal of Pathology, 页码：2388-2399 , 文章类型： Article，,卷期：2009年174-6]
- Both Eph receptors and ephrin ligands have been implicated in blood vessel and neuronal development. Recent studies suggested that EphA2 inhibition reduces tumor angiogenesis, but its role in blood vessel development and...
- Alternative Proteolytic Processing of Hepatocyte Growth Factor during Wound Repair
[作者：Buchstein, N; Hoffmann, D; Smola, H; Lang, S; Paulsson, M; Niemann, C; Krieg, T; Eming, SA,期刊：American Journal of Pathology, 页码：2116-2128 , 文章类型： Article，,卷期：2009年174-6]
- Wound heating is a crucial regenerative process in all organisms. We examined expression, integrity, and function of the proteins in the hepatocyte growth factor (HGF)/c-Met signaling pathway in normally healing and non-...
- Disruption of Interleukin-1 Signaling Improves the Quality of Wound Healing
[作者：Thomay, AA; Daley, JM; Sabo, E; Worth, PJ; Shelton, LJ; Harty, MW; Reichner, JS; Albina, JE,期刊：American Journal of Pathology, 页码：2129-2136 , 文章类型： Article，,卷期：2009年174-6]
In this study, we investigated the role of interleukin (IL)-1 signaling in wound heating. IL-1 receptor type I (IL-1R) knockout (KO) mice showed reduced fibrosis in both cutaneous and deep tissue wounds, which was acc...
- Oxidative Stress and Compartment of Gene Expression Determine Proatherosclerotic Effects of Inducible Nitric Oxide Synthase
[作者：Ponnuswamy, P; Ostermeier, E; Schrottle, A; Chen, J; Huang, PL; Ertl, G; Nieswandt, B; Kuhlencordt, PJ,期刊：American Journal of Pathology, 页码：2400-2410 , 文章类型： Article，,卷期：2009年174-6]
- Genetic and pharmacological inhibition of inducible nitric oxide synthase (iNOS) decreases atherosclerosis development. Potential proatherogenic effects of iNOS include iNOS mediated oxidative stress and iNOS expression ...
- Homeostatic Role of Transforming Growth Factor-beta in the Oral Cavity and Esophagus of Mice and Its Expression by Mast Cells in These Tissues
[作者：Vitsky, A; Waire, J; Pawliuk, R; Bond, A; Matthews, D; LaCasse, E; Hawes, ML; Nelson, C; Richards, S; Piepenhagen, PA; Garman, RD; Andrews, L; Thurberg, BL; Lonning, S; Ledbetter, S; Ruzek, MC,期刊：American Journal of Pathology, 页码：2137-2149 , 文章类型： Article，,卷期：2009年174-6]
- Transforming growth factor-beta (TGF-beta) is a pleiotropic growth factor; its overexpression has been implicated in many diseases, making it a desirable target for therapeutic neutralization. In initial safety studies, ...
- The Methylation of the TSC2 Promoter Underlies the Abnormal Growth of TSC2 Angiomyolipoma-Derived Smooth Muscle Cells
[作者：Lesma, E; Sirchia, SM; Ancona, S; Carelli, S; Bosari, S; Ghelma, F; Montanari, E; Di Giulio, AM; Gorio, A,期刊：American Journal of Pathology, 页码：2150-2159 , 文章类型： Article，,卷期：2009年174-6]
- Tuberous sclerosis complex (TSC) is an autosomal-dominant disease that is caused by mutations in either the TSC1 or TSC2 gene. Smooth muscle-like cells (ASMs) were isolated from an angiomyolipoma of a patient with TSC. T...
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