- Epigenetic Modulation of Cancer-Germline Antigen Gene Expression in Tumorigenic Human Mesenchymal Stem Cells Implications for Cancer Therapy
[作者:Gjerstorff, M; Burns, JS; Nielsen, O; Kassem, M; Ditzel, H,期刊:American Journal of Pathology, 页码:314-323 , 文章类型: Article,,卷期:2009年175-1]
- Cancer-germline antigens are promising targets for cancer immunotherapy, but whether such therapies will also eliminate the primary tumor stem cell population remains undetermined. We previously showed that long-term cul...
- Deregulation of IKBKE Is Associated with Tumor Progression, Poor Prognosis, and Cisplatin Resistance in Ovarian Cancer
[作者:Guo, JP; Shu, SK; He, L; Lee, YC; Kruk, PA; Grenman, S; Nicosia, SV; Mor, G; Schell, MJ; Coppola, D; Cheng, JQ,期刊:American Journal of Pathology, 页码:324-333 , 文章类型: Article,,卷期:2009年175-1]
- I-kappa-B kinase e (IKBKE; IKK epsilon) has been recently identified as a breast cancer oncogene, and its alteration appears to be an early event in breast cancer development. in this study, we demonstrated that IKK epsi...
- Identification of Glutathione S-Transferase Pi as a Protein Involved in Parkinson Disease Progression
[作者:Shi, M; Bradner, J; Bammler, TK; Eaton, DL; Zhang, JP; Ye, ZC; Wilson, AM; Montine, TJ; Pan, C; Zhang, J,期刊:American Journal of Pathology, 页码:54-65 , 文章类型: Article,,卷期:2009年175-1]
- Parkinson disease (PD) typically affects the cortical regions during the later stages of disease, with neuronal loss, gliosis, and formation of diffuse cortical Lewy bodies in a significant portion of patients with demen...
- The Influence of Tumor-Host Interactions in the Stromal Cell-Derived Factor-1/CXCR4 Ligand/Receptor Axis in Determining Metastatic Risk in Breast Cancer
[作者:Hassan, S; Ferrario, C; Saragovi, U; Quenneville, L; Gaboury, L; Baccarelli, A; Salvucci, O; Basik, M,期刊:American Journal of Pathology, 页码:66-73 , 文章类型: Article,,卷期:2009年175-1]
- The chemokine stromal cell-derived factor-1 (SDF-1) may function to attract CXCR4-expressing cancer cells to metastatic organs. We have previously demonstrated that low plasma SDF-1, a host-derived marker, increases dist...
- Prognostic Significance of Stromal Platelet-Derived Growth Factor beta-Receptor Expression in Human Breast Cancer
[作者:Paulsson, J; Sjoblom, T; Micke, P; Ponten, F; Landberg, G; Heldin, CH; Bergh, J; Brennan, DJ; Jirstrom, K; Ostman, A,期刊:American Journal of Pathology, 页码:334-341 , 文章类型: Article,,卷期:2009年175-1]
- This study systematically analyzes platelet-derived growth factor (PDGF) receptor expression in six types of common tumors as well as examines associations between PDGF beta-receptor status and clinicopathological charac...
- NOLC1, an Enhancer of Nasopharyngeal Carcinoma Progression, Is Essential for TP53 to Regulate MDM2 Expression
[作者:Hwang, YC; Lu, TY; Huang, DY; Kuo, YS; Kao, CF; Yeh, NH; Wu, HC; Lin, CT,期刊:American Journal of Pathology, 页码:342-354 , 文章类型: Article,,卷期:2009年175-1]
- Nasopharyngeal carcinoma (NPC) is one of the most common cancers among Chinese living in South China, Singapore, and Taiwan. At present, its etiological factors are not well defined. To identify which genetic alterations...
- Decrease in Tumor Necrosis Factor-alpha Receptor-Associated Death Domain Results from Ubiquitin-Dependent Degradation in Obstructive Renal Injury in Rats
[作者:Misaki, T; Yamamoto, T; Suzuki, S; Fukasawa, H; Togawa, A; Ohashi, N; Suzuki, H; Fujigaki, Y; Oda, T; Uchida, C; Kitagawa, K; Hattori, T; Kitagawa, M; Hishida, A,期刊:American Journal of Pathology, 页码:74-83 , 文章类型: Article,,卷期:2009年175-1]
- Increased expression levels of tumor necrosis factor-alpha (TNF alpha) is involved in tubulointerstitial cell proliferation and apoptosis in obstructive renal injury. Two TNF alpha receptors (TNFRs), TNFR1 and TNFR2, are...
- Complex Integration of Matrix, Oxidative Stress, and Apoptosis in Genetic Emphysema
[作者:Podowski, M; Calvi, CL; Cheadle, C; Tuder, RM; Biswals, S; Neptune, ER,期刊:American Journal of Pathology, 页码:84-96 , 文章类型: Article,,卷期:2009年175-1]
- Alveolar enlargement, which is characteristic of bronchopulmonary dysplasia, congenital matrix disorders, and cigarette smoke-induced emphysema, is thought to result from enhanced inflammation and ensuing excessive matri...
- High Fat Diet Induced Hepatic Steatosis Establishes a Permissive Microenvironment for Colorectal Metastases and Promotes Primary Dysplasia in a Murine Model
[作者:VanSaun, MN; Lee, IK; Washington, MK; Matrisian, L; Gorden, DL,期刊:American Journal of Pathology, 页码:355-364 , 文章类型: Article,,卷期:2009年175-1]
- Non-alcoholic fatty liver disease (NARD), which includes steatosis and its progression to non-alcoholic steatohepatitis, is a liver disorder of increasing clinical significance. Here we characterize a murine model of hig...
- Gastrin Is an Essential Cofactor for Helicobacter-Associated Gastric Corpus Carcinogenesis in C57BL/6 Mice
[作者:Takaishi, S; Tu, SP; Dubeykovskaya, ZA; Whary, MT; Muthupalani, S; Rickman, BH; Rogers, AB; Lertkowit, N; Varro, A; Fox, JG; Wang, TC,期刊:American Journal of Pathology, 页码:365-375 , 文章类型: Article,,卷期:2009年175-1]
- We have previously described a synergistic interaction between hypergastrinemia and Helicobacter felis infection on gastric corpus carcitiogenesis in FVB/N mice housed under specific-pathogen-free conditions.However, gas...
- Deletion of Activating Fc gamma Receptors Does Not Confer Protection in Murine Cryoglobulinemia-Associated Membranoproliferative Glomerulonephritis
[作者:Guo, S; Muhlfeld, AS; Wietecha, TA; Peutz-Kootstra, CJ; Kowalewska, J; Yi, K; Spencer, M; Pichaiwong, W; Nimmerjahn, F; Hudkins, KL; Alpers, CE,期刊:American Journal of Pathology, 页码:107-118 , 文章类型: Article,,卷期:2009年175-1]
- Many types of glomerulonephritis are initiated by the deposition of immune complexes, which induce tissue injury via either engagement of Fc receptors on effector cells or via complement activation. Four murine Fc gamma ...
- Modulation of the E2F1-Driven Cancer Cell Fate by the DNA Damage Response Machinery and Potential Novel E2F1 Targets in Osteosarcomas
[作者:Liontos, M; Niforou, K; Velimezi, G; Vougas, K; Evangelou, K; Apostolopoulou, K; Vrtel, R; Damalas, A; Kontovazenitis, P; Kotsinas, A; Zoumpourlis, V; Tsangaris, GT; Kittas, C; Ginsberg, D; Halazonetis, TD; Bartek, J; Gorgoulis, VG,期刊:American Journal of Pathology, 页码:376-391 , 文章类型: Article,,卷期:2009年175-1]
- Osteosarcoma is the most common primary bone cancer. Mutations of the RB gene represent the most frequent molecular defect in this malignancy. A major consequence of this alteration is that the activity of the key cell c...
- Efficient Renal Recruitment of Macrophages and T Cells in Mice Lacking the Duffy Antigen/Receptor for Chemokines
[作者:Vielhauer, V; Allam, R; Lindenmeyer, MT; Cohen, CD; Draganovici, D; Mandelbaum, J; Eltrich, N; Nelson, PJ; Anders, HJ; Pruenster, M; Rot, A; Schlodorff, D; Segerer, S,期刊:American Journal of Pathology, 页码:119-131 , 文章类型: Article,,卷期:2009年175-1]
- The Duffy antigen/receptor for chemokines (DARC) is a chemokine-binding protein that is expressed on erythrocytes and renal endothelial cells. DARC-mediated endothelial transcytosis of chemokines may facilitate the renal...
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