- Modeling the activity of furin inhibitors using artificial neural network
[作者:Worachartcheewan, A; Nantasenamat, C; Naenna, T; Isarankura-Na-Ayudhya, C; Prachayasittikul, V,期刊:European Journal of Medicinal Chemistry, 页码:1664-1673 , 文章类型: Article,,卷期:2009年44-4]
- Quantitative structure-activity relationship (QSAR) models were constructed for predicting the inhibition of furin-dependent processing of anthrax protective antigen of substituted guanidinylated aryl 2,5-dideoxystreptam...
- Synthesis and pharmacological evaluation of a novel series of 5-(substituted) aryl-3-(3-coumarinyl)-1-phenyl-2-pyrazolines as novel anti-inflammatory and analgesic agents
[作者:Khode, S; Maddi, V; Aragade, P; Palkar, M; Ronad, PK; Mamledesai, S; Thippeswamy, AHM; Satyanarayana, D,期刊:European Journal of Medicinal Chemistry, 页码:1682-1688 , 文章类型: Article,,卷期:2009年44-4]
- A novel series of 5-(substituted)aryl-3-(3-coumarinyl)-1phenyl-2-pyrazolines (3a-1) were synthesized by reacting various substituted 3-aryl-1-(3-coumarinyl)propan-1-ones (2a-1) with phenylhydrazine in the presence of hot...
- Synthesis, evaluation and 3D QSAR analysis of novel estradiol-RGD octapeptide conjugates with oral anti-osteoporosis activity
[作者:Liu, JY; Zhang, XY; Zhao, M; Peng, SQ,期刊:European Journal of Medicinal Chemistry, 页码:1689-1704 , 文章类型: Article,,卷期:2009年44-4]
- To enhance the potency, reduce the side effects and improve oral property of estradiol in estrogen replacement therapy (ERT), 6 novel estradiol-RGD octapeptide conjugates have been prepared. In an ovariectomized mouse os...
- A facile synthesis of alpha,alpha '-(EE)-bis(benzylidene)-cycloalkanones and their antitubercular evaluations
[作者:Singh, N; Pandey, J; Yadav, A; Chaturvedi, V; Bhatnagar, S; Gaikwad, AN; Sinha, SK; Kumar, A; Shukla, PK; Tripathi, RP,期刊:European Journal of Medicinal Chemistry, 页码:1705-1709 , 文章类型: Article,,卷期:2009年44-4]
- An economical and facile synthesis of alpha,alpha'-(EE)-bis(benzylidene)-cycloalkanones was achieved by the reaction of cycloalkanones with different aromatic aldehydes using ethanolic KOH in good yields. Few of the sele...
- Novel 4-aryl-pyrido[1,2-c]pyrimidines with dual SSRI and 5-HT1A activity, Part 1
[作者:Herold, F; Chodkowski, A; Izbicki, L; Krol, M; Kleps, J; Turlo, J; Nowak, G; Stachowicz, K; Dybala, M; Siwek, A,期刊:European Journal of Medicinal Chemistry, 页码:1710-1717 , 文章类型: Article,,卷期:2009年44-4]
- A series of new derivatives of 4-aryl-pyrido[1,2-c]pyrimidine containing the 3-(4-piperidyl)-1H-indole residue or its 5-methoxy derivative were synthesized. They were characterized (i) in vitro by binding to 5-HT1A recep...
- Synthesis and pharmacological evaluation of 2-substituted benzo[b]thiophenes as anti-inflammatory and analgesic agents
[作者:Fakhr, IMI; Radwan, MAA; El-Batran, S; El-Salam, OMEA; El-Shenawy, SM,期刊:European Journal of Medicinal Chemistry, 页码:1718-1725 , 文章类型: Article,,卷期:2009年44-4]
- An efficient method for trapping isocyanate 4, generated from the Curtius rearrangement, with ethyl alcohol to afford the carbamate 5 is reported. 5-Nitrobenzo[b]thiophene-2-carboxylic acid 1 is converted to the correspo...
- Improved synthesis of seven aromatic Baylis-Hillman adducts (BHA): Evaluation against Artemia salina Leach. and Leishmania chagasi
[作者:Barbosa, TP; Junior, CGL; Silva, FPL; Lopes, HM; Figueiredo, LRF; Sousa, SCO; Batista, GN; da Silva, TG; Silva, TMS; de Oliveira, MR; Vasconcellos, MLAA,期刊:European Journal of Medicinal Chemistry, 页码:1726-1730 , 文章类型: Article,,卷期:2009年44-4]
- We described a very efficient procedure to prepare seven aromatic compounds (1-7), a new class of antileishmanial substances, through Baylis-Hillman reaction (BHR). With one, all the Baylis-Hillman adducts were prepared ...
- Synthesis and spectroscopic studies of biologically active compounds derived from oxalyldihydrazide and benzil, and their Cr(III), Fe(III) and Mn(III) complexes
[作者:Singh, DP; Kumar, R; Singh, J,期刊:European Journal of Medicinal Chemistry, 页码:1731-1736 , 文章类型: Article,,卷期:2009年44-4]
- A new series of complexes have been synthesized by template condensation of oxalyldihydrazide and benzil in methanolic medium in the presence of trivalent chromium, manganese and iron salts forming complexes of the type ...
- Synthesis and antibacterial evaluation of novel 4-alkyl substituted phenyl beta-aldehyde ketone derivatives
[作者:Liu, JB; Cao, RH; Wu, QF; Ma, CM; Wang, ZH; Peng, WL; Song, HC,期刊:European Journal of Medicinal Chemistry, 页码:1737-1744 , 文章类型: Article,,卷期:2009年44-4]
- A series of novel 4-alkylphenyl beta-aldehyde ketones and their derivatives were designed and synthesized on the basis of the chemical structures of Houttuynin and beta-lactam antibiotics. Antibacterial activities of the...
- Comparative study of the trypanocidal activity of the methyl 1-nitrophenyl-1,2,3,4-9H-tetrahydro-beta-carboline-3-carboxylate derivatives and benznidazole using theoretical calculations and cyclic voltammetry
[作者:Tonin, LTD; Barbosa, VA; Bocca, CC; Ramos, ERF; Nakamura, CV; da Costa, WF; Basso, EA; Nakamura, TU; Sarragiotto, MH,期刊:European Journal of Medicinal Chemistry, 页码:1745-1750 , 文章类型: Article,,卷期:2009年44-4]
- The cis and trans isomers of methyl 1-(m-nitro)phenyl and 1-(p-nitro)phenyl-1,2,3,4-tetrahydro-9H-beta-carboline-3-carboxylates (compounds 3a,b, 4a and b) were synthesized and evaluated in vitro against epimastigote form...
- Nitroimidazolyl-1,3,4-thiadiazole-based anti-leishmanial agents: Synthesis and in vitro biological evaluation
[作者:Poorrajab, F; Ardestani, SK; Emami, S; Behrouzi-Fardmoghadam, M; Shafiee, A; Foroumadi, A,期刊:European Journal of Medicinal Chemistry, 页码:1758-1762 , 文章类型: Article,,卷期:2009年44-4]
- A series of 1-[5-(1-methyl-5-nitro-1H-imidazol-2-yl)-1,3,4-thiadiazol-2-yl]-4-aroylpiperazines were synthesized and evaluated in vitro against Leishmania major. Most of the target compounds exhibited good anti-leishmania...
- Self-activating chemical nuclease: Ferrocenyl cyclen Cu(II) complexes act as efficient DNA cleavage reagents in the absence of reductant
[作者:Li, K; Zhou, LH; Zhang, J; Chen, SY; Zhang, ZW; Zhang, JJ; Lin, HH; Yu, XQ,期刊:European Journal of Medicinal Chemistry, 页码:1768-1772 , 文章类型: Article,,卷期:2009年44-4]
- The interactions of cyclen Cu(II) complexes functionalized by ferrocenyl group with plasmid DNA indicated that these complexes have high cleavage efficiency via an oxidative mechanism in the absence of any reductant or o...
- A class of potent tyrosinase inhibitors: Alkylidenethiosemicarbazide compounds
[作者:Liu, JB; Cao, RH; Yi, W; Ma, CM; Wan, YQ; Zhou, BH; Ma, L; Song, HC,期刊:European Journal of Medicinal Chemistry, 页码:1773-1778 , 文章类型: Article,,卷期:2009年44-4]
- A series of alkylidenethiosemicarbazide compounds were synthesized and their inhibitory effects on the diphenolase activity of mushroom tyrosinase were evaluated. The results showed that most of the synthesized compounds...
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