- Copper-Facilitated Suzuki Reactions: Application to 2-Heterocyclic Boronates.
[作者:Deng, James Z.;Paone, Daniel V.;Ginnetti, Anthony T.;Kurihara, Hideki;Dreher, Spencer D.;Weissman, Steven A.;Stauffer, Shaun R.;Burgey, Christopher S.;,期刊:Organic Letters, 页码:345-347 , 文章类型: 研究论文,,卷期:2009年11-2]
- The palladium-catalyzed Suzuki-Miyaura reaction has been utilized as one of the most powerful methods for C-C bond formation. However, Suzuki reactions of electron-deficient 2-heterocyclic boronates generally give low c...
- A New Catalytic Prins Cyclization Leading to Oxa- and Azacycles.
[作者:Miranda, Pedro O.;Carballo, Ruben M.;Martin, Victor S.;Padron, Juan I.;,期刊:Organic Letters, 页码:357-360 , 文章类型: 研究论文,,卷期:2009年11-2]
- A new Prins cyclization process that builds up one carbon-carbon bond, one heteroatom-carbon bond, and one halogen-carbon bond, (in an oxa- and azacycle) relies on an iron catalyst system formed from Fe(acac)3 and trimet...
- Catalytic Asymmetric 1,3-Dipolar Cycloaddition of Azomethine Ylides with a,b-Unsaturated Ketones.
[作者:Hernandez-Toribio, Jorge;Gomez Arrayas, Ramon;Martin-Matute, Belen;Carretero, Juan C.;,期刊:Organic Letters, 页码:393-396 , 文章类型: 研究论文,,卷期:2009年11-2]
- a,b-Unsatd. ketones are no longer the missing dipolarophiles in catalytic asym. 1,3-dipolar cycloaddn. of azomethine ylides. In the presence of CuI-Fesulfos complexes as catalysts (5 mol %), these substrates combine hig...
- Stereogenic Motif Consisting of Rigid Ring and Intraannular Chains: Isolation and Structures of Stereoisomers of 9-Alkyl-1,8-anthrylene-Butadiynylene Cyclic Dimers.
[作者:Toyota, Shinji;Onishi, Hiroyuki;Kawai, Yoshihiro;Morimoto, Takaaki;Miyahara, Hiroaki;Iwanaga, Tetsuo;Wakamatsu, Kan;,期刊:Organic Letters, 页码:321-324 , 文章类型: 研究论文,,卷期:2009年11-2]
- isomerization is attributed to the steric hindrance between the alkyl chains and the rigid framework.
- Total Synthesis of Brevetoxin A.
[作者:Crimmins, Michael T.;Zuccarello, J. Lucas;Ellis, J. Michael;McDougall, Patrick J.;Haile, Pamela A.;Parrish, Jonathan D.;Emmitte, Kyle A.;,期刊:Organic Letters, 页码:489-492 , 文章类型: 研究论文,,卷期:2009年11-2]
- A total synthesis of brevetoxin A (I) is reported. Two tetracyclic coupling partners, prepd. from previously reported advanced fragments, were effectively united via a Horner-Wittig olefination. The resulting octacycle...
- Stable Preformed Chiral Palladium Catalysts for the One-Pot Asymmetric Reductive Amination of Ketones.
[作者:Rubio-Perez, Laura;Perez-Flores, F. Javier;Sharma, Pankaj;Velasco, Luis;Cabrera, Armando;,期刊:Organic Letters, 页码:265-268 , 文章类型: 研究论文,,卷期:2009年11-2]
- The application of air stable preformed [(R)-BINAP]PdBr2, [(S)-BINAP]PdBr2, [(R)-Tol-BINAP]PdBr2, and [(S,S)-CHIRAPHOS]PdBr2 complexes in the one-pot asym. reductive amination of various carbonyl compds., leading to chir...
- Palladium-Catalyzed Cross Coupling Reaction of Benzyl Bromides with Diazoesters for Stereoselective Synthesis of (E)-a,b-Diarylacrylates.
[作者:Yu, Wing-Yiu;Tsoi, Yuk-Tai;Zhou, Zhongyuan;Chan, Albert S. C.;,期刊:Organic Letters, 页码:469-472 , 文章类型: 研究论文,,卷期:2009年11-2]
- A Pd-catalyzed cross-coupling reaction of benzyl bromides with a-aryldiazoesters is described, and E-a,b-diarylacrylates were obtained in good yields and excellent E-to-Z selectivity (>20:1).
- Palladium-Catalyzed, One-Pot, Three-Component Synthesis of Homoallylic Amines from Aldehydes, Anisidine, and Allyl Trifluoroacetate.
[作者:Grote, Robin E.;Jarvo, Elizabeth R.;,期刊:Organic Letters, 页码:485-488 , 文章类型: 研究论文,,卷期:2009年11-2]
- An allylation reaction that generates homoallylic amines using allyl trifluoroacetate as a nucleophilic allylmetal precursor is reported. A palladium complex catalyzes two transformations in one pot: formation of allyls...
- Enantioselective, Ketoreductase-Based Entry into Pharmaceutical Building Blocks: Ethanol as Tunable Nicotinamide Reductant.
[作者:Broussy, Sylvain;Cheloha, Ross W.;Berkowitz, David B.;,期刊:Organic Letters, 页码:305-308 , 文章类型: 研究论文,,卷期:2009年11-2]
- The use of NADH- and NADPH-dependent ketoreductases to access enantio-enriched pharmaceutical building blocks is reported. Seven structurally diverse synthons are obtained, including those for atomoxetine (KRED 132), ta...
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