- Practical Synthesis of a p38 MAP Kinase Inhibitor.
[作者:Achmatowicz, Michal;Thiel, Oliver R.;Wheeler, Philip;Bernard, Charles;Huang, Jinkun;Larsen, Robert D.;Faul, Margaret M.;,期刊:Journal of Organic Chemistry, 页码:795-809 , 文章类型: 研究论文,,卷期:2009年74-2]
- P38 MAP kinase inhibitors have attracted considerable interest as potential agents for the treatment of inflammatory diseases. Herein, we describe a concise and efficient synthesis of inhibitor I that is based on a phth...
- Synthesis of Conformationally Constrained Peptidomimetics using Multicomponent Reactions.
[作者:Scheffelaar, Rachel;Klein Nijenhuis, Roel A.;Paravidino, Monica;Lutz, Martin;Spek, Anthony L.;Ehlers, Andreas W.;de Kanter, Frans J. J.;Groen, Marinus B.;Orru, Romano V. A.;Ruijter, Eelco;,期刊:Journal of Organic Chemistry, 页码:660-668 , 文章类型: 研究论文,,卷期:2009年74-2]
- A novel modular synthetic approach toward constrained peptidomimetics is reported. The approach involves a highly efficient three-step sequence including two multicomponent reactions, thus allowing unprecedented diversi...
- Densely Functionalized Chiral Pyrroles from Endocyclic, Exocyclic, and Acyclic Vinyl Sulfone-Modified Carbohydrates.
[作者:Bhattacharya, Rahul;Atta, Ananta Kumar;Dey, Debanjana;Pathak, Tanmaya;,期刊:Journal of Organic Chemistry, 页码:669-674 , 文章类型: 研究论文,,卷期:2009年74-2]
- A wide range of vinyl sulfone-modified carbohydrates have been prepd. as starting materials for the synthesis of polysubstituted chiral pyrroles, e.g. I. All these vinyl sulfones reacted efficiently with ethylisocyanoac...
- Multinuclear NMR study of the solution structure and reactivity of tris(trimethylsilyl)methyllithium and its iodine ate complex.
[作者:Reich, Hans J.;Sikorski, William H.;Sanders, Aaron W.;Jones, Amanda C.;Plessel, Kristin N.;,期刊:Journal of Organic Chemistry, 页码:719-729 , 文章类型: 研究论文,,卷期:2009年74-2]
- Soln. dynamics and equil. of tris(trimethylsilyl)methyl derivs. (Me3Si)3CX (1-X), specifically of tris(trimethylsilyl)methyllithium (1-Li) solvate forms [Li(solv)n][[(Me3Si)3C]2Li] (1T), contact ion pair (Me3Si)3CLi (1C)...
- Expedient Synthesis of 3-Alkoxymethyl- and 3-Aminomethyl-Pyrazolo[3,4-b]pyridines.
[作者:Beutner, Gregory L.;Kuethe, Jeffrey T.;Kim, Mary M.;Yasuda, Nobuyoshi;,期刊:Journal of Organic Chemistry, 页码:789-794 , 文章类型: 研究论文,,卷期:2009年74-2]
- An effective strategy has been developed for the prepn. of 3-alkoxymethyl-pyrazolo[3,4-b]pyridines, i.e. I, compds. that are currently not readily accessible by existing synthetic methods. Further manipulation of these ...
- Tandem Electrophilic Cyclization-[3+2] Cycloaddition-Rearrangement Reactions of 2-Alkynylbenzaldoxime, DMAD, and Br2.
[作者:Ding, Qiuping;Wang, Zhiyong;Wu, Jie;,期刊:Journal of Organic Chemistry, 页码:921-924 , 文章类型: 研究论文,,卷期:2009年74-2]
- Tandem electrophilic cyclization-[3+2] cycloaddn.-rearrangement reactions of 2-alkynylbenzaldoximes, DMAD, and bromine are described, which afford the unexpected isoquinoline-based azomethine ylides, e. g. I, in good to ...
- A Cascade Approach to Pyridines from 2-Azido-2,4-dienoates and a-Diazocarbonyl Compounds.
[作者:Chen, Zheng-Bo;Hong, Deng;Wang, Yan-Guang;,期刊:Journal of Organic Chemistry, 页码:903-905 , 文章类型: 研究论文,,卷期:2009年74-2]
- A one-pot synthesis of substituted pyridines, e.g. I (R = H, Me, Br, MeO), via a cascade reaction of 2-azido-2,4-dienoates with a-diazocarbonyl compds. and triphenylphosphine is reported. The process involves a Stauding...
- A Short Entry to a-Substituted g-Alkylidene Pentenolides. Synthesis and Preliminary Biological Evaluation of Novel Gelastatin Analogues.
[作者:Pavlik, Jan;Snajdr, Ivan;Kunes, Jiri;Spulak, Marcel;Pour, Milan;,期刊:Journal of Organic Chemistry, 页码:703-709 , 文章类型: 研究论文,,卷期:2009年74-2]
- Biol. interesting 2-substituted 4-alkylidene pentenolides, e.g, I, were prepd. with complete control of regio- and stereoselectivity from 2-iodo allylic alcs. via an array of Pd-catalyzed processes, including alkynylatio...
- 2,7-Substituted Hexafluoroheterofluorenes as Potential Building Blocks for Electron Transporting Materials.
[作者:Geramita, Katharine;McBee, Jennifer;Tilley, T. Don;,期刊:Journal of Organic Chemistry, 页码:820-829 , 文章类型: 研究论文,,卷期:2009年74-2]
- A series of 2,7-substituted hexafluoro-9-heterofluorenes, i.e. I, was synthesized via nucleophilic arom. substitution (SNArF) reactions of phenyllithium, thienyllithium, and lithium phenylacetylide with various octafluor...
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