- Selectively Targeting T- and B-Cell Lymphomas: A Benzothiazole Antagonist of a4b1 Integrin.
[作者：Carpenter, Richard D.;Andrei, Mirela;Aina, Olulanu H.;Lau, Edmond Y.;Lightstone, Felice C.;Liu, Ruiwu;Lam, Kit S.;Kurth, Mark J.;,期刊：Journal of Medicinal Chemistry, 页码：14-19 , 文章类型： 研究论文，,卷期：2009年52-1]
- Current cancer chemotherapeutic agents clin. deployed today are designed to be indiscriminately cytotoxic, however, achieving selective targeting of cancer malignancies would allow for improved diagnostic and chemotherap...
- Synthesis and Anti-Hepatitis B Virus and Anti-Hepatitis C Virus Activities of 7-Deazaneplanocin A Analogues in Vitro.
[作者：Kim, Hyo-Joong;Sharon, Ashoke;Bal, Chandralata;Wang, Jianing;Allu, Madhan;Huang, Zhuhui;Murray, Michael G.;Bassit, Leda;Schinazi, Raymond F.;Korba, Brent;Chu, Chung K.;,期刊：Journal of Medicinal Chemistry, 页码：206-213 , 文章类型： 研究论文，,卷期：2009年52-1]
- A series of 7-deazaneplanocin A analogs were synthesized and evaluated for in vitro antiviral activity against HBV and HCV. The syntheses of target carbocyclic nucleosides were accomplished via a convergent procedure. ...
- Synthesis and Biological Evaluation of Vinca Alkaloids and Phomopsin Hybrids.
[作者：Ngo, Quoc Anh;Roussi, Fanny;Cormier, Anthony;Thoret, Sylviane;Knossow, Marcel;Guenard, Daniel;Gueritte, Francoise;,期刊：Journal of Medicinal Chemistry, 页码：134-142 , 文章类型： 研究论文，,卷期：2009年52-1]
- Ten hybrids I [X = CH2, (CH2)2; R = L-Pro-OMe, L-Pro-L-Ile-OCH2Ph, L-Pro-L-Ile-OH, L-Pro-L-Ile-L-Asp(OCH2Ph)2, L-Pro-L-Ile-L-Asp-OH] of Vinca alkaloids and phomopsin A analogs were synthesized by linking the octahydropho...
- Synthesis, Radiosynthesis, and Biological Evaluation of Carbon-11 and Fluorine-18 Labeled Reboxetine Analogues: Potential Positron Emission Tomography Radioligands for in Vivo Imaging of the Norepinephrine Transporter.
[作者：Zeng, Fanxing;Mun, Jiyoung;Jarkas, Nachwa;Stehouwer, Jeffrey S.;Voll, Ronald J.;Tamagnan, Gilles D.;Howell, Leonard;Votaw, John R.;Kilts, Clinton D.;Nemeroff, Charles B.;Goodman, Mark M.;,期刊：Journal of Medicinal Chemistry, 页码：62-73 , 文章类型： 研究论文，,卷期：2009年52-1]
- Reboxetine analogs with Me and fluoroalkyl substituents at position 2 of the phenoxy ring I [R = 2-MeC6H4O (II), 2-FCH2CH2C6H4O (III), 2-FCH2CH2CH2C6H4O (IV), 2-MeC6H4S (V)] were synthesized. In vitro competition bindin...
- Synthesis and Evaluation of Novel Inhibitors of Pim-1 and Pim-2 Protein Kinases.
[作者：Xia, Zuping;Knaak, Christian;Ma, Jian;Beharry, Zanna M.;McInnes, Campbell;Wang, Wenxue;Kraft, Andrew S.;Smith, Charles D.;,期刊：Journal of Medicinal Chemistry, 页码：74-86 , 文章类型： 研究论文，,卷期：2009年52-1]
- The Pim protein kinases are frequently overexpressed in prostate cancer and certain forms of leukemia and lymphoma. 5-(3-Trifluoromethylbenzylidene)thiazolidine-2,4-dione (I) was identified by screening to be a Pim-1 inh...
- New Uracil Dimers Showing Erythroid Differentiation Inducing Activities.
[作者：Accetta, Alessandro;Corradini, Roberto;Sforza, Stefano;Tedeschi, Tullia;Brognara, Eleonora;Borgatti, Monica;Gambari, Roberto;Marchelli, Rosangela;,期刊：Journal of Medicinal Chemistry, 页码：87-94 , 文章类型： 研究论文，,卷期：2009年52-1]
- The synthesis of C5 linked uracil dimers, e.g. I, was carried out according to a model developed in order to bind adenine in DNA. N1-Alkylated uracil derivs. were synthesized from isoorotic acid (uracil-5-carboxylic acid...
- New Derivatives of Farnesylthiosalicylic Acid (Salirasib) for Cancer Treatment: Farnesylthiosalicylamide Inhibits Tumor Growth in Nude Mice Models.
[作者：Goldberg, Liat;Haklai, Roni;Bauer, Victor;Heiss, Aaron;Kloog, Yoel;,期刊：Journal of Medicinal Chemistry, 页码：197-205 , 文章类型： 研究论文，,卷期：2009年52-1]
- The Ras inhibitor S-trans,trans-farnesylthiosalicylic acid (FTS, Salirasib) interferes with Ras membrane interactions that are crucial for Ras-dependent transformation. It remains unknown whether modifications of the ca...
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