- OTT-MAL is a deregulated activator of serum response factor-dependent gene expression
[作者:Descot, A; Rex-Haffner, M; Courtois, G; Bluteau, D; Menssen, A; Mercher, T; Bernard, OA; Treisman, R; Posern, G,期刊:Molecular and Cellular Biology, 页码:6171-6181 , 文章类型: Article,,卷期:2008年28-20]
- The OTT-MAL/RBM15-MKL1 fusion protein is the result of the recurrent translocation t(1;22) in acute megakaryocytic leukemia in infants. How it contributes to the malignancy is unknown. The 3' fusion partner, MAL/MKL1/MRT...
- Deletion of Mtg16, a target of t(16;21), alters hematopoietic progenitor cell proliferation and lineage allocation
[作者:Chyla, BJ; Moreno-Miralles, I; Steapleton, MA; Thompson, MA; Bhaskara, S; Engel, M; Hiebert, SW,期刊:Molecular and Cellular Biology, 页码:6234-6247 , 文章类型: Article,,卷期:2008年28-20]
- While a number of DNA binding transcription factors have been identified that control hematopoietic cell fate decisions, only a limited number of transcriptional corepressors (e. g., the retinoblastoma protein [pRB] and ...
- Lactate stimulates vasculogenic stem cells via the thioredoxin system and engages an autocrine activation loop involving hypoxia-inducible factor 1
[作者:Milovanova, TN; Bhopale, VM; Sorokina, EM; Moore, JS; Hunt, TK; Hauer-Jensen, M; Velazquez, OC; Thom, SR,期刊:Molecular and Cellular Biology, 页码:6248-6261 , 文章类型: Article,,卷期:2008年28-20]
- The recruitment and differentiation of circulating stem/progenitor cells (SPCs) in subcutaneous Matrigel in mice was assessed. There were over one million CD34(+) SPCs per Matrigel plug 18 h after Matrigel implantation, ...
- The histone acetyltransferase PCAF associates with actin and hnRNP U for RNA polymerase II transcription
[作者:Obrdlik, A; Kukalev, A; Louvet, E; Farrants, AKO; Caputo, L; Percipalle, P,期刊:Molecular and Cellular Biology, 页码:6342-6357 , 文章类型: Article,,卷期:2008年28-20]
- Actin is a key regulator of RNA polymerase (pol) II transcription. In complex with specific hnRNPs, it has been proposed that actin functions to recruit pol II coactivators during the elongation of nascent transcripts. H...
- Effects of the SANT domain of tension-induced/inhibited proteins (TIPs), novel partners of the histone acetyltransferase p300, on p300 activity and TIP-6-induced adipogenesis
[作者:Badri, KR; Zhou, YX; Dhru, U; Aramgam, S; Schuger, L,期刊:Molecular and Cellular Biology, 页码:6358-6372 , 文章类型: Article,,卷期:2008年28-20]
- We previously identified a set of transcription regulators, referred to as TIPs (tension-induced/inhibited proteins), with a role in myogenic versus adipogenic differentiation. Here we report that the TIP family comprise...
- Epigenetic regulation of retrotransposons within the nucleolus of Drosophila
[作者:Eickbush, DG; Ye, JQ; Zhang, X; Burke, WD; Eickbush, TH,期刊:Molecular and Cellular Biology, 页码:6452-6461 , 文章类型: Article,,卷期:2008年28-20]
- R2 retrotransposable elements exclusively insert into a conserved region of the tandemly organized 28S rRNA genes. Despite inactivating a subset of these genes, R2 elements have persisted in the ribosomal DNA ( rDNA) loc...
- Phosphorylation of p27(Kip1) regulates assembly and activation of cyclin D1-Cdk4
[作者:Larrea, MD; Liang, JY; Da Silva, T; Hong, F; Shao, SH; Han, K; Dumont, D; Slingerland, JM,期刊:Molecular and Cellular Biology, 页码:6462-6472 , 文章类型: Article,,卷期:2008年28-20]
- p27 mediates Cdk2 inhibition and is also found in cyclin D1-Cdk4 complexes. The present data support a role for p27 in the assembly of D-type cyclin-Cdk complexes and indicate that both cyclin D1-Cdk4-p27 assembly and ki...
- CTCF regulates allelic expression of Igf2 by orchestrating a promoter-polycomb repressive complex 2 intrachromosomal loop
[作者:Li, T; Hu, JF; Qiu, XW; Ling, JQ; Chen, HL; Wang, SK; Hou, AJ; Vu, TH; Hoffman, AR,期刊:Molecular and Cellular Biology, 页码:6473-6482 , 文章类型: Article,,卷期:2008年28-20]
- CTCF is a zinc finger DNA-binding protein that regulates the epigenetic states of numerous target genes. Using allelic regulation of mouse insulin-like growth factor II (Igf2) as a model, we demonstrate that CTCF binds t...
- TRAF6 and the three C-terminal lysine sites on IRF7 are required for its ubiquitination-mediated activation by the tumor necrosis factor receptor family member latent membrane protein 1
[作者:Ning, SB; Campos, AD; Darnay, BG; Bentz, GL; Pagano, JS,期刊:Molecular and Cellular Biology, 页码:6536-6546 , 文章类型: Article,,卷期:2008年28-20]
- We have recently shown that interferon regulatory factor 7 (IRF7) is activated by Epstein-Barr virus latent membrane protein 1 (LMP1), a member of the tumor necrosis factor receptor (TNFR) superfamily, through receptor-i...
- Inhibition of polysome assembly enhances imatinib activity against chronic myelogenous leukemia and overcomes imatinib resistance
[作者:Zhang, M; Fu, WX; Prabhu, S; Moore, JC; Ko, J; Kim, JW; Druker, BJ; Trapp, V; Fruehauf, J; Gram, H; Fan, HY; Ong, ST,期刊:Molecular and Cellular Biology, 页码:6496-6509 , 文章类型: Article,,卷期:2008年28-20]
- Dysregulated mRNA translation is implicated in the pathogenesis of many human cancers including chronic myelogenous leukemia (CML). Because our prior work has specifically implicated translation initiation in CML, we tes...
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