- Synthesis and antimycobacterial evaluation of substituted pyrazinecarboxamides
[作者:Dolezal, M; Cmedlova, P; Palek, L; Vinsova, J; Kunes, J; Buchta, V; Jampilek, J; Kralova, K,期刊:European Journal of Medicinal Chemistry, 页码:1105-1113 , 文章类型: Article,,卷期:2008年43-5]
Unsubstituted, halogenated and/or alkylated pyrazine-2-carboxylic acid amides connected via -CONH- bridge with substituted anilines were synthesized using currently known synthetic pathways. The synthetic approach, an...
- N-{[(6-Substituted-1,3-benzothiazole-2-yl)amino]carbonothioyl}-2/4-substituted benzamides: Synthesis and pharmacological evaluation
[作者:Rana, A; Siddiqui, N; Khan, SA; Haque, SE; Bhat, MA,期刊:European Journal of Medicinal Chemistry, 页码:1114-1122 , 文章类型: Article,,卷期:2008年43-5]
A series of 1,3-benzothiazol-2-yl benzamides (11-30) were prepared in satisfactory yield and evaluated for their anticonvulsant, neurotoxicity, CNS depressant study and other toxicity studies. All the synthesized comp...
- 4-Nitroacetophenone-derived thiosemicarbazones and their copper(II) complexes with significant in vitro anti-trypanosomal activity
[作者:Perez-Rebolledo, A; Teixeira, LR; Batista, AA; Mangrich, AS; Aguirre, G; Cerecetto, H; Gonzalez, M; Hernandez, P; Ferreira, AM; Speziali, NL; Beraldo, H,期刊:European Journal of Medicinal Chemistry, 页码:939-948 , 文章类型: Article,,卷期:2008年43-5]
N-4-Methyl-4-nitroacetophenone thiosemicarbazone (H4NO2Ac4M, 1), N-4,N-4-dimethyl-4-nitroacetophenone thiosemicarbazone (H4NO2 Ac4DM, 2) and N4-piperidyl-4-nitroacetophenone thiosemicarbazone (H(4)NO(2)Ac(4)Pip, 3) an...
- 3D-QSAR studies of Checkpoint Kinase Weel inhibitors based on molecular docking, CoMFA and CoMSIA
[作者:Yi, P; Fang, X; Qiu, MH,期刊:European Journal of Medicinal Chemistry, 页码:925-938 , 文章类型: Article,,卷期:2008年43-5]
Three-dimensional quantitative structure-activity relationship (3D-QSAR) studies were performed on 97 4-phenylpyrrolo[3,4-c]-carbazole-1,3(2H,6H)-dione inhibitors, based on molecular docking scores obtained by using G...
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