- Synthesis and antibacterial activity of bis-[2-hydroxy-3-(1,7,8,9,10-pentamethyl-3,5-dioxo-4-aza-tricyclo[5.2.1.0(2,6)] dec-8-en-4-yloxy)-propyl]-dimethyl-ammonium chloride
[作者:Struga, M; Kossakowski, J; Stefanska, J; Zimniak, A; Koziol, AE,期刊:European Journal of Medicinal Chemistry, 页码:1309-1314 , 文章类型: Article,,卷期:2008年43-6]
A new quaternary ammonium compound, bis-[2-hydroxy-3-(1,7,8,9,10-pentamethyl-3,5-dioxo-4-aza-tricyclo[5.2.1.0(2,6)]dec-8-en-4-yloxy)-propyl]-dimethyl-ammonium chloride (4), was synthesized. The compound was investigat...
- Design and evaluation of anacardic acid derivatives as anticavity agents
[作者:Green, IR; Tocoli, FE; Lee, SH; Nihei, K; Kubo, I,期刊:European Journal of Medicinal Chemistry, 页码:1315-1320 , 文章类型: Article,,卷期:2008年43-6]
On the basis of antibacterial anacardic acids, 6-pentadecenylsalicylic acids, isolated from the cashew apple, Anacardium occidentale L. (Anacardiaceae), a series of 6-alk(en)ylsalicylic acids were synthesized and test...
- Structure of a novel thrombin inhibitor with an uncharged D-amino acid as P1 residue
[作者:Friedrich, R; Riester, D; Gottig, P; Thurk, M; Schwienhorst, A; Bode, W,期刊:European Journal of Medicinal Chemistry, 页码:1330-1335 , 文章类型: Article,,卷期:2008年43-6]
Thrombin, the ultimate proteinase of the coagulation cascade, is an attractive target for the treatment of a variety of cardiovascular diseases. Previously, a series of novel thrombin inhibitors, discovered by employi...
- Synthesis and antiproliferative activity of aryl- and heteroaryl-hydrazones derived from xanthone carbaldehydes
[作者:Varache-Lembege, M; Moreau, S; Larrouture, S; Montaudon, D; Robert, J; Nuhrich, A,期刊:European Journal of Medicinal Chemistry, 页码:1336-1343 , 文章类型: Article,,卷期:2008年43-6]
In order to explore the antiproliferative effect associated with the xanthone framework, several arylhydrazonomethyl derivatives were synthesized from various isomeric 1,3-dihydroxyxanthone carbaldehydes. Variation in...
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