2-Euryfuryl- and 2-euryfuryl-3-nitro-1,4-benzoquinone Q2 and Q3, prepared via oxidative coupling reactions of sesquiterpene euryfuran 1 to 2-nitro-1,4-benzoquinone and 1,4-benzoquinone, were tested for their cytotoxic...

2-(Alicyclic-amino)-4,6-diaryl-3-pyridinecarboxylates 5a-d were prepared via aromatic nucleophilic substitution reaction of secondary amines, (piperidine or morpholine) with 2-bromo-3-pyridinecarboxylate derivatives 3...

Twenty-six enamines were synthesized to screen for the antimicrobial activity. Out of the compounds, 22 were reported for the first time. Their chemical structures including E/Z-configurations were clearly determined ...

The monoesters of curcumin, a symmetric diphenol with valine and glycine have been prepared by a novel solid phase synthesis and its diesters with valine, glutamic acid and demethylenated piperic acid have been prepar...

Eighteen new 2,6-disubstituted acrylonitriles and two new (benzimidazol-1-yl)-acetamide derivatives were prepared and screened for antibacterial and cytotoxic activities on 12 human cancer cell lines. Based on the lea...

New benzimidazole-4,7-diones substituted at 2-position were synthesized via a microwave-assisted reaction using 2-chloromethyl-1,5,6-tri-methyl-1H-benzimidazole-4,7-dione 5b as a key intermediate compound. Their cytot...

The inhibitory potency of ursolic acid extracted from flex paraguariensis, a plant used in South American population for a tea preparation known as mate, and its derivatives to inhibit aromatase activity was assessed ...

The synthesis and tumor-inhibitory activity of a series of aminonaphthoquinone derivatives of diospyrin, which was isolated from Diospyros montana Roxb., are presented here for the first time. An aminoacetate derivati...

A series of pyrazoline derivatives with beta-amino acyl group were synthesized and evaluated for their ability to inhibit dipeptidyl peptidase IV. Several pyrazoline derivatives exhibited submicromolar inhibitory acti...

As a continuation of our research and with the aim of obtaining new antimalarial agents, new series of 3-phenylquinoxaline 1,4-di-N-oxide derivatives have been synthesized following the classical Beirut reaction. Anti...

According to a water-in-oil emulsion technique using POCl3 as a cross-linking agent, starch nanoparticles have been prepared. Using this starch nanoparticles, loaded polyoxometalates (POMs) alpha-K8H6 [Si2W18Ti6O77] (...

This paper describes molecular docking studies of a series of classical NSAIDs with PPAR gamma receptor, which has been pointed as a new target for the design of anti-cancer and anti-inflammatory drugs, and has been f...

Melatonin is a neurohormone synthesized and secreted mainly during the dark period of the circadian cycle by the pineal gland. It has already been proved to be involved in a number of chronobiological processes, most ...