- 20-hydroxyeicosatetraenoic acid stimulates nuclear factor-kappa B activation and the production of inflammatory cytokines in human endothelial cells
[作者:Ishizuka, T; Cheng, J; Singh, H; Vitto, MD; Manthati, VL; Falck, JR; Laniado-Schwartzman, M,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:103-110 , 文章类型: Article,,卷期:2008年324-1]
Endothelial dysfunction is associated with endothelial cell activation, i.e., up-regulation of surface cell adhesion molecules and the release of proinflammatory cytokines. 20-Hydroxyeicosatetraenoic acid (HETE), a ma...
- [H-3]A-585539 [(1S,4S)-2,2-Dimethyl-5-(6-phenylpyridazin-3-yl)-5-aza-2-azoniabicyclo[2.2.1]heptane], a novel high-affinity alpha 7 neuronal nicotinic receptor agonist: Radioligand binding characterization to rat and human brain
[作者:Anderson, DJ; Bunnelle, W; Surber, B; Du, J; Surowy, C; Tribollet, E; Marguerat, A; Bertrand, D; Gopalakrishnan, M,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:179-187 , 文章类型: Article,,卷期:2008年324-1]
Receptor binding was characterized for [H-3](1S,4S)-2,2-dimethyl5-(6-phenylpyridazin-3-yl)-5-aza-2-azoniabicyclo[2.2.1]heptane([3H]A-585539), a selective high-affinity alpha 7 nicotinic acetylcholine receptor (nAChR) ...
- Modulation of nicotinamide adenine dinucleotide phosphate oxidase expression and function by 3 ',4 '-dihydroxyflavonol in phagocytic and vascular cells
[作者:Jiang, F; Guo, N; Dusting, GJ,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:261-269 , 文章类型: Article,,卷期:2008年324-1]
Previously we have demonstrated that 3 ', 4 '-dihydroxyflavonol (DiOHF), a novel synthetic flavonol, protects against ischemia reperfusion injury in both heart and brain. In this study, we characterized the pharmacolo...
- N-methylacetamide analog of salvinorin A: A highly potent and selective kappa-opioid receptor agonist with oral efficacy
[作者:Beguin, C; Potter, DN; DiNieri, JA; Munro, TA; Richards, MR; Paine, TA; Berry, L; Zhao, Z; Roth, BL; Xu, W; Liu-Chen, LY; Carlezon, WA; Cohen, BM,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:188-195 , 文章类型: Article,,卷期:2008年324-1]
Several preclinical studies indicate that selective kappa-opioid receptor (KOR) antagonists have antidepressant-like effects, whereas KOR agonists have opposite effects, suggesting that each might be useful in the tre...
- Pharmacological characterization of indacaterol, a novel once daily inhaled beta(2) adrenoceptor agonist, on small airways in human and rat precision-cut lung slices
[作者:Sturton, RG; Trifilieff, A; Nicholson, AG; Barnes, PJ,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:270-275 , 文章类型: Article,,卷期:2008年324-1]
Indacaterol is a novel once daily inhaled beta(2) adrenoceptor agonist in clinical development. This study compared the properties of indacaterol with salmeterol, formoterol, and albuterol on small airways in precisio...
- Actions of two main metabolites of propiverine (M-1 and m-2) on voltage-dependent L-type Ca2+ currents and Ca2+ transients in murine urinary bladder myocytes
[作者:Zhu, HL; Brain, KL; Aishima, M; Shibata, A; Young, JS; Sueishi, K; Teramoto, N,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:118-127 , 文章类型: Article,,卷期:2008年324-1]
The anticholinergic propiverine (1-methyl-4-piperidyl diphenylpropoxyacetate), which is used for the treatment of overactive bladder syndrome, has functionally active metabolites [M-1(1-methyl-4-piperidyl diphenylprop...
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