- Thiopental protects human T lymphocytes from apoptosis in vitro via the expression of heat shock protein 70
[作者:Roesslein, M; Schibilsky, D; Muller, L; Goebel, U; Schwer, C; Humar, M; Schmidt, R; Geiger, KK; Pahl, HL; Pannen, BHJ; Loop, T,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:217-225 , 文章类型: Article,,卷期:2008年325-1]
Barbiturates, which are used for the treatment of intracranial hypertension after severe head injury, have been associated with anti-inflammatory side effects. Although all barbiturates inhibit T-cell function, only t...
- Treatment of sepsis-induced acquired protein C deficiency reverses angiotensin-converting enzyme-2 inhibition and decreases pulmonary inflammatory response
[作者:Richardson, MA; Gupta, A; O'Brien, LA; Berg, DT; Gerlitz, B; Syed, S; Sharma, GR; Cramer, MS; Heuer, JG; Galbreath, EJ; Grinnell, BW,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:17-26 , 文章类型: Article,,卷期:2008年325-1]
The protein C (PC) pathway plays an important role in vascular and immune function, and acquired deficiency during sepsis is associated with increased mortality in both animal models and in clinical studies. However, ...
- Discovery and characterization of novel tryptophan hydroxylase inhibitors that selectively inhibit serotonin synthesis in the gastrointestinal tract
[作者:Liu, QY; Yang, Q; Sun, WM; Vogel, P; Heydorn, W; Yu, XQ; Hu, ZX; Yu, WS; Jonas, B; Pineda, R; Calderon-Gay, V; Germann, M; O'Neill, E; Brommage, R; Cullinan, E; Platt, K; Wilson, A; Powell, D; Sands, A; Zambrowicz, B; Shi, ZC,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:47-55 , 文章类型: Article,,卷期:2008年325-1]
5-Hydroxytryptamine (serotonin) (5-HT) is a neurotransmitter with both central and peripheral functions, including the modulation of mood, appetite, hemodynamics, gastrointestinal (GI) sensation, secretion, and motili...
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