- Correlation between ex vivo receptor occupancy and wake-promoting activity of selective H-3 receptor antagonists
[作者:Le, SY; Gruner, JA; Mathiasen, JR; Marino, MJ; Schaffhauser, H,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:902-909 , 文章类型: Article,,卷期:2008年325-3]
The histamine H-3 receptor (H3R) modulates the release of neurotransmitters that are involved in vigilance, cognition, and sleep-wake regulation. H3R antagonism has been proposed as a novel approach to the treatment o...
- Effects of spinal alpha(2)-adrenoceptor and I-1-imidazoline receptor activation on hindlimb movement induction in spinal cord-injured mice
[作者:Lapointe, NP; Ung, RV; Rouleau, P; Guertin, PA,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:994-1006 , 文章类型: Article,,卷期:2008年325-3]
A partial recovery of locomotor functions has been shown in spinal cord-transected (Tx) cats after regular treadmill training and repeated administration of clonidine, an alpha(2)-adrenoreceptor agonist. However, clon...
- Plant-derived cannabinoids modulate the activity of transient receptor potential channels of ankyrin type-1 and melastatin type-8
[作者:De Petrocellis, L; Vellani, V; Schiano-Moriello, A; Marini, P; Magherini, PC; Orlando, P; Di Marzo, V,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:1007-1015 , 文章类型: Article,,卷期:2008年325-3]
The plant cannabinoids (phytocannabinoids), cannabidiol (CBD), and Delta(9)-tetrahydrocannabinol (THC) were previously shown to activate transient receptor potential channels of both vanilloid type 1 (TRPV1) and ankyr...
- New role of resistin in lipopolysaccharide-induced liver damage in mice
[作者:Beier, JI; Guo, LP; von Montfort, C; Kaiser, JP; Joshi-Barve, S; Arteel, GE,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:801-808 , 文章类型: Article,,卷期:2008年325-3]
Studies in rodents suggest that the adipocytokine resistin causes insulin resistance via impairing normal insulin signaling. However, in humans, resistin may play a more important role in inflammation than in insulin ...
- Assessment of nerve stimulation-induced release of purines from mouse kidneys by tandem mass spectrometry
[作者:Ren, J; Mi, ZC; Jackson, EK,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:920-926 , 文章类型: Article,,卷期:2008年325-3]
Adenosine, formed from AMP and metabolized to inosine, modulates renal sympathetic neurotransmission. The present study had two goals: 1) to develop ultrasensitive and specific mass spectrometry-based assays for cAMP,...
- Parallel improvement of sodium and chloride transport defects by miglustat (n-butyldeoxynojyrimicin) in cystic fibrosis epithelial cells
[作者:Noel, S; Wilke, M; Bot, AGM; De Jonge, HR; Becq, F,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:1016-1023 , 文章类型: Article,,卷期:2008年325-3]
Cystic fibrosis, an autosomal recessive disease frequently diagnosed in the Caucasian population, is characterized by deficient Cl- transport due to mutations in the cystic fibrosis transmembrane conductance regulator...
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