- Serotonin 5-Hydroxytryptamine(2A) Receptor Activation Suppresses Tumor Necrosis Factor-alpha-Induced Inflammation with Extraordinary Potency
[作者:Yu, BN; Becnel, J; Zerfaoui, M; Rohatgi, R; Boulares, H; Nichols, CD,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:316-323 , 文章类型: Article,,卷期:2008年327-2]
The G protein-coupled serotonin 5-hydroxytryptamine (5-HT) 2A receptor is primarily recognized for its role in brain neurotransmission, where it mediates a wide variety of functions, including certain aspects of cogni...
- N-Arachidonyl Maleimide Potentiates the Pharmacological and Biochemical Effects of the Endocannabinoid 2-Arachidonylglycerol through Inhibition of Monoacylglycerol Lipase
[作者:Burston, JJ; Sim-Selley, LJ; Harloe, JP; Mahadevan, A; Razdan, RK; Selley, DE; Wiley, JL,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:546-553 , 文章类型: Article,,卷期:2008年327-2]
Inhibition of the metabolism of the endocannabinoids, anandamide (AEA) and 2-arachidonyl glycerol (2-AG), by their primary metabolic enzymes, fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL), respe...
- Bivalirudin Decreases NO Bioavailability by Vascular Immobilization of Myeloperoxidase
[作者:Rudolph, V; Rudolph, TK; Schopfer, FJ; Bonacci, G; Lau, D; Szocs, K; Klinke, A; Meinertz, T; Freeman, BA; Baldus, S,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:324-331 , 文章类型: Article,,卷期:2008年327-2]
Bivalirudin, a direct thrombin inhibitor, has emerged as an important alternative to heparin in patients undergoing percutaneous coronary intervention. However, it remains elusive if potentially adverse extracoagulant...
- Antiatherosclerotic Effects of a Novel Synthetic Tissue-Selective Steroidal Liver X Receptor Agonist in Low-Density Lipoprotein Receptor-Deficient Mice
[作者:Peng, DC; Hiipakka, RA; Dai, Q; Guo, J; Reardon, CA; Getz, GS; Liao, SS,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:332-342 , 文章类型: Article,,卷期:2008年327-2]
Liver X receptor (LXR) agonists have the potential to treat atherosclerosis based on their ability to enhance reverse cholesterol transport. However, their side effects, such as induction of liver lipogenesis and trig...
- Inhibition of Calpain Prevents N-Methyl-D-aspartate-Induced Degeneration of the Nucleus Basalis and Associated Behavioral Dysfunction
[作者:Nimmrich, V; Szabo, R; Nyakas, C; Granic, I; Reymann, KG; Schroder, UH; Gross, G; Schoemaker, H; Wicke, K; Moller, A; Luiten, P,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:343-352 , 文章类型: Article,,卷期:2008年327-2]
N-Methyl-D-aspartate( NMDA) receptor-mediated excitotoxicity is thought to underlie a variety of neurological disorders, and inhibition of either the NMDA receptor itself, or molecules of the intracellular cascade, ma...
- Morphine Tolerance in the Mouse Ileum and Colon
[作者:Ross, GR; Gabra, BH; Dewey, WL; Akbarali, HI,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:561-572 , 文章类型: Article,,卷期:2008年327-2]
Repeated administration of morphine is associated with tolerance to its antinociceptive properties. However, constipation remains the major side effect of chronic exposure to morphine. In contrast, previous studies su...
- Dual Pathway Activated by tert-Butyl Hydroperoxide in Human Airway Anion Secretion
[作者:Matsuno, T; Ito, Y; Ohashi, T; Morise, M; Takeda, N; Shimokata, K; Imaizumi, K; Kume, H; Hasegawa, Y,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:453-464 , 文章类型: Article,,卷期:2008年327-2]
We analyzed the mechanisms underlying the ion transport induced by tert-butyl hydroperoxide (t-BOOH), a membrane-permeant oxidant that has been widely used as a model of oxidative stress, in human airway epithelial ce...
- Antidepressant-Like Pharmacological Profile of a Novel Triple Reuptake Inhibitor, (1S, 2S)-3-(Methylamino)-2-(naphthalen-2-yl)-1-phenylpropan-1-ol (PRC200-SS)
[作者:Liang, YQ; Shaw, AM; Boules, M; Briody, S; Robinson, J; Oliveros, A; Blazar, E; Williams, K; Zhang, Y; Carlier, PR; Richelson, E,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:573-583 , 文章类型: Article,,卷期:2008年327-2]
Due to the putative involvement of dopaminergic circuits in depression, triple reuptake inhibitors are being developed as a new class of antidepressant, which is hypothesized to produce a more rapid onset and better e...
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