- Do Desipramine [10, 11-Dihydro-5-[3-(methylamino) propyl]-5H-dibenz[b, f]azepine monohydrochloride] and Fluoxetine [N-Methyl-3-phenyl-3-[4-(trifluoromethyl) phenoxy]-propan-1-amine] Ameliorate the Extent of Colonic Damage Induced by Acetic Acid in Rats?
[作者:Guemei, AA; El Din, NMN; Baraka, AM; Darwish, IE,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:846-850 , 文章类型: Article,,卷期:2008年327-3]
The present study was designed to compare the anti-inflammatory and antioxidant effects of two antidepressant drugs, desipramine [10, 11-dihydro-5-[3-(methylamino) propyl]-5H-dibenz[b, f]azepine monohydrochloride] and...
- Niacin-induced "Flush" Involves Release of Prostaglandin D-2 from Mast Cells and Serotonin from Platelets: Evidence from Human Cells in Vitro and an Animal Model
[作者:Papaliodis, D; Boucher, W; Kempuraj, D; Michaelian, M; Wolfberg, A; House, M; Theoharides, TC,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:665-672 , 文章类型: Article,,卷期:2008年327-3]
Niacin lowers serum cholesterol, low-density lipoprotein, and triglycerides, and it raises high-density lipoprotein. However, most patients experience cutaneous warmth and vasodilation (flush). Acetylsalicylic acid (A...
- Comparison of Cigarette Smoke-Induced Acute Inflammation in Multiple Strains of Mice and the Effect of a Matrix Metalloproteinase Inhibitor on These Responses
[作者:Morris, A; Kinnear, G; Wan, WYH; Wyss, D; Bahra, P; Stevenson, CS,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:851-862 , 文章类型: Article,,卷期:2008年327-3]
The activities of proteases in the lung, specifically matrix metalloproteinases (MMPs), have been implicated in driving the inflammation and lung destruction observed in smokers with chronic obstructive pulmonary dise...
- Heme Oxygenase-1 Inhibits the Proliferation of Pancreatic Stellate Cells by Repression of the Extracellular Signal-Regulated Kinase1/2 Pathway
[作者:Schwer, CI; Guerrero, AM; Humar, M; Roesslein, M; Goebel, U; Stoll, P; Geiger, KK; Pannen, BHJ; Hoetzel, A; Schmidt, R,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:863-871 , 文章类型: Article,,卷期:2008年327-3]
Activation of pancreatic stellate cells (PSCs) is the key process in the development of pancreatic fibrosis, a common feature of chronic pancreatitis and pancreatic cancer. In recent studies, curcumin has been shown t...
- NIM811 (N-Methyl-4-isoleucine Cyclosporine), a Mitochondrial Permeability Transition Inhibitor, Attenuates Cholestatic Liver Injury but Not Fibrosis in Mice
[作者:Rehman, H; Ramshesh, VK; Theruvath, TP; Kim, I; Currin, RT; Giri, S; Lemasters, JJ; Zhong, Z,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:699-706 , 文章类型: Article,,卷期:2008年327-3]
Cholestasis causes hepatocyte death, possibly because of mitochondrial injury. This study investigated whether NIM811 (N-methyl-4-isoleucine cyclosporine), an inhibitor of the mitochondrial permeability transition (MP...
- The 5-Hydroxytryptamine(2A) Receptor Antagonist R-(+)-alpha-( 2,3-Dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl-4-piperidinemethanol (M100907) Attenuates Impulsivity after Both Drug-Induced Disruption (Dizocilpine) and Enhancement (Antidepressant Drugs) of Differential-Reinforcement-of-Low-Rate 72-s Behavior in the Rat
[作者:Ardayfio, PA; Benvenga, MJ; Chaney, SF; Love, PL; Catlow, J; Swanson, SP; Marek, GJ,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:891-897 , 文章类型: Article,,卷期:2008年327-3]
Previous work has suggested that N-methyl-D-aspartate (NMDA) receptor antagonism and 5-hydroxytryptamine (5-HT)(2A) receptor blockade may enhance and attenuate, respectively, certain types of impulsivity mediated by c...
- Identification and Characterization of NDT 9513727 [N,N-bis(1,3-Benzodioxol-5-ylmethyl)-1-butyl-2,4-diphenyl-1H-imidazole-5-methanamine], a Novel, Orally Bioavailable C5a Receptor Inverse Agonist
[作者:Brodbeck, RM; Cortright, DN; Kieltyka, AP; Yu, JY; Baltazar, CO; Buck, ME; Meade, R; Maynard, GD; Thurkauf, A; Chien, DS; Hutchison, AJ; Krause, JE,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:898-909 , 文章类型: Article,,卷期:2008年327-3]
The complement system represents an innate immune mechanism of host defense that has three effector arms, the C3a receptor, the C5a receptor (C5aR), and the membrane attack complex. Because of its inflammatory and imm...
- Pharmacology of Macitentan, an Orally Active Tissue-Targeting Dual Endothelin Receptor Antagonist
[作者:Iglarz, M; Binkert, C; Morrison, K; Fischli, W; Gatfield, J; Treiber, A; Weller, T; Bolli, MH; Boss, C; Buchmann, S; Capeleto, B; Hess, P; Qiu, C; Clozel, M,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:736-745 , 文章类型: Article,,卷期:2008年327-3]
Macitentan, also called Actelion-1 or ACT-064992 [N-[5-(4-bromophenyl)-6-(2-(5-bromopyrimidin-2-yloxy)ethoxy)-pyrimidin-4-yl]-N'-propylaminosulfonamide], is a new dual E(T)A/ETB endothelin (ET) receptor antagonist des...
- Ethanol Decreases Purkinje Neuron Excitability by Increasing GABA Release in Rat Cerebellar Slices
[作者:Mameli, M; Botta, P; Zamudio, PA; Zucca, S; Valenzuela, CF,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:910-917 , 文章类型: Article,,卷期:2008年327-3]
Cerebellar Purkinje neurons (PNs) receive inhibitory GABAergic input from stellate and basket cells, which are located in the outer and inner portions of the molecular layer, respectively. Ethanol (EtOH) was recently ...
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