- Modulation of Sodium Channel Inactivation Gating by a Novel Lactam: Implications for Seizure Suppression in Chronic Limbic Epilepsy
[作者:Jones, PJ; Merrick, EC; Batts, TW; Hargus, NJ; Wang, YS; Stables, JP; Bertram, EH; Brown, ML; Patel, MK,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:201-212 , 文章类型: Article,,卷期:2009年328-1]
Epilepsy remains a devastating neurological disorder associated with recurrent, unprovoked, spontaneous epileptic seizures. Current treatments involve seizure suppression using antiepileptic drugs (AEDs); however, man...
- Catecholamines Relax Detrusor through beta(2)-Adrenoceptors in Mouse and beta(3)-Adrenoceptors in Man
[作者:Wuest, M; Eichhorn, B; Grimm, MO; Wirth, MP; Ravens, U; Kaumann, AJ,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:213-222 , 文章类型: Article,,卷期:2009年328-1]
(-)-Isoproterenol [4-[1-hydroxy-2-[(1-methylethyl) amino] ethyl]1,2-benzene diol hydrochloride] relaxes murine detrusor through beta-adrenoceptors (ARs); however, the beta-AR subtypes involved are unknown. beta(2)-ARs...
- Increased Oxidant Activity Mediates Vascular Dysfunction in Vibration Injury
[作者:Hughes, JM; Wirth, O; Krajnak, K; Miller, R; Flavahan, S; Berkowitz, DE; Welcome, D; Flavahan, NA,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:223-230 , 文章类型: Article,,卷期:2009年328-1]
Occupational exposure to hand-operated vibrating tools causes a spectrum of pathological changes in the vascular, neurological, and musculoskeletal systems described as the hand-arm vibration syndrome (HAVS). Experime...
- Epoxyeicosatrienoic Acids Function as Selective, Endogenous Antagonists of Native Thromboxane Receptors: Identification of a Novel Mechanism of Vasodilation
[作者:Behm, DJ; Ogbonna, A; Wu, C; Burns-Kurtis, CL; Douglas, SA,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:231-239 , 文章类型: Article,,卷期:2009年328-1]
Epoxy- and dihydroxy-eicosatrienoic acids (EETs and DHETs) are vasoactive cytochrome P450 metabolites of arachidonic acid. Interestingly, however, the mechanism(s) by which EETs/ DHETs mediate smooth muscle relaxation...
- Chronic Cocaine-Induced Cardiac Oxidative Stress and Mitogen-Activated Protein Kinase Activation: The Role of Nox2 Oxidase
[作者:Fan, L; Sawbridge, D; George, V; Teng, L; Bailey, A; Kitchen, I; Li, JM,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:99-106 , 文章类型: Article,,卷期:2009年328-1]
Chronic cocaine exposure is associated with severe cardiac complications, but the mechanisms of cocaine cardiotoxicity remain unclear, and current therapies are unsatisfactory. We investigated the hypothesis of oxidat...
- Risperidone Attenuates Local and Systemic Inflammatory Responses to Ameliorate Diet-Induced Severe Necrotic Pancreatitis in Mice: It May Provide a New Therapy for Acute Pancreatitis
[作者:Yamaguchi, I; Hamada, K; Yoshida, M; Isayama, H; Kanazashi, S; Takeuchi, K,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:256-262 , 文章类型: Article,,卷期:2009年328-1]
In a previous article, we showed that a potent serotonin-, 5-hydroxytryptamine-2A (5-HT2A) antagonist, risperidone, ameliorated cerulein-induced edematous pancreatitis in mice. In the present article, young female mic...
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