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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共27条记录   Towards novel S-DABOC inhibitors: Synthesis, biological investigation, and molecular modeling studies [作者：Radi, M; Angeli, L; Franchi, L; Contemori, L; Maga, G; Samuele, A; Zanoli, S; Armand-Ugon, M; Gonzalez, E; Llano, A; Este, JA; Botta, M,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：5777-5780 , 文章类型： Article，,卷期：2008年18-21] A small family of S-DABO cytosine analogs (S-DABOCs) has been synthesized and biologically evaluated as HIV-1 inhibitor both on wild type (wt) and drug-resistant mutants leading to the identification of an interesting co... Synthesis and free radical scavenging activity of some new spiropyranocoumarins [作者：Panteleon, V; Kostakis, IK; Marakos, P; Pouli, N; Andreadou, I,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：5781-5784 , 文章类型： Article，,卷期：2008年18-21] A series of novel spiro-substituted 4-hydroxypyranocoumarins and their corresponding dihydropyrano cis-diols has been synthesized. Among them the spiroadamantylpyranocoumarin and the diols can interact with the stable fr... Application of a trifunctional reactive linker for the construction of antibody-drug hybrid conjugates [作者：Thomas, JD; Hofer, T; Rader, C; Burke, TR,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：5785-5788 , 文章类型： Article，,卷期：2008年18-21] A flexible, trifunctional poly(ethylene glycol)-succinamide-Lysine-Lysine-maleimide (PEG-SU-Lys-Lysmal) linker was employed to simultaneously allow biotin tagging and cell-surface targeting through an integrin alpha(4)be... The identification of neurotensin NTS1 receptor partial agonists through a ligand-based virtual screening approach [作者：Fan, Y; Lai, MH; Sullivan, K; Popiolek, M; Andree, TH; Dollings, P; Pausch, MH,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：5789-5791 , 文章类型： Article，,卷期：2008年18-21] We identified small molecule NTS1R agonist compounds through virtual screening of the corporate database using a ROCS approach that searches multi-conformer representations efficiently. As a starting point for the ROCS s... Synthesis and biological evaluation of a novel decadentate ligand DEPA [作者：Chong, HS; Lim, S; Baidoo, KE; Milenic, DE; Ma, X; Jia, F; Song, HA; Brechbiel, MW; Lewis, MR,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：5792-5795 , 文章类型： Article，,卷期：2008年18-21] An efficient and short synthetic route to a novel decadentate ligand 7-[2-(bis-carboxymethyl-amino)-ethyl]-4,10-bis-carboxymethyl-1,4,7,10-tetraaza-cyclododec-1-yl-acetic acid (DEPA) with both macrocyclic and acyclic bin... 2-Aryloxymethylmorpholine histamine H-3 antagonists [作者：Letavic, MA; Keith, JM; Ly, KS; Bonaventure, P; Feinstein, MA; Lord, B; Miller, KL; Motley, ST; Nepomuceno, D; Sutton, SW; Carruthers, NI,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：5796-5799 , 文章类型： Article，,卷期：2008年18-21] The synthesis and biological activity of a new series of 2-aryloxymethylmorpholine histamine H-3 antagonists is described. The new compounds are high affinity histamine H-3 ligands that penetrate the CNS and occupy the h... One-pot synthesis and antibacterial activities of pyrazolo[4 ',3 ':5,6]pyrido[2,3-d]pyrimidine-dione derivatives [作者：Bazgir, A; Khanaposhtani, MM; Soorki, AA,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：5800-5803 , 文章类型： Article，,卷期：2008年18-21] A one-pot and efficient method for the synthesis of pyrazolo[4',3':5,6] pyrido[2,3-d]pyrimidine-dione derivatives by condensation reaction of barbituric acids, 1H-pyrazol-5-amines and aldehydes under solvent-free conditi... Piperidine dispiro-1,2,4-trioxane analogues [作者：Sabbani, S; Stocks, PA; Ellis, GL; Davies, J; Hedenstrom, E; Ward, SA; O'Neill, PM,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：5804-5808 , 文章类型： Article，,卷期：2008年18-21] Dispiro N-Boc-protected 1,2,4-trioxane 2 was synthesised via Mo(acac)(2) catalysed perhydrolysis of N-Boc spirooxirane followed by condensation of the resulting beta-hydroperoxy alcohol 10 with 2-adamantanone. N-Boc 1,2,... Discovery of novel hydroxamates as highly potent tumor necrosis factor-alpha converting enzyme inhibitors. Part II: Optimization of the S3 ' pocket [作者：Mazzola, RD; Zhu, ZN; Sinning, L; McKittrick, B; Lavey, B; Spitler, J; Kozlowski, J; Neng-Yang, S; Zhou, GW; Guo, ZY; Orth, P; Madison, V; Sun, J; Lundell, D; Niu, XD,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：5809-5814 , 文章类型： Article，,卷期：2008年18-21] A series of cyclopropyl hydroxamic acids were prepared. Many of the compounds displayed picomolar affinity for the TACE enzyme while maintaining good to excellent selectivity profiles versus MMP-1, - 2, - 3, - 7, - 14, a... Synthesis and antibacterial activities of novel oxazolidinones having cyclic sulfonamide moieties [作者：Kim, SJ; Jung, MH; Yoo, KH; Cho, JH; Oh, CH,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：5815-5818 , 文章类型： Article，,卷期：2008年18-21] The synthesis of a new series of oxazolidinones having cyclic sulfonamide moieties is described. Their in vitro antibacterial activities against both Gram-positive and Gram-negative bacteria were tested and the effect of... Synthesis and structure-activity relationship of benzetimide derivatives as human CXCR3 antagonists [作者：Bongartz, JP; Buntinx, M; Coesemans, E; Hermans, B; Van Lommen, G; Van Wauwe, J,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：5819-5823 , 文章类型： Article，,卷期：2008年18-21] The synthesis and evaluation of benzetimide derivatives showing potent CXCR3 antagonism are described. Optimization of the screening hits led to the identification of more potent CXCR3 antagonists devoid of anti-choliner...