- Synthesis and in vitro antimycobacterial activity of B-ring modified diaryl ether InhA inhibitors
[作者:Ende, CWA; Knudson, SE; Liu, N; Childs, J; Sullivan, TJ; Boyne, M; Xu, H; Gegina, Y; Knudson, DL; Johnson, F; Peloquin, CA; Slayden, RA; Tonge, PJ,期刊:Bioorganic & Medicinal Chemistry Letters, 页码:3029-3033 , 文章类型: Proceedings Paper,,卷期:2008年18-10]
- Previous structure-based design studies resulted in the discovery of alkyl substituted diphenyl ether inhibitors of InhA, the enoyl reductase from Mycobacterium tuberculosis. Compounds such as 5-hexyl-2-phenoxyphenol 19 ...
- Mechanism based protein crosslinking of domains from the 6-deoxyerythronolide B synthase
[作者:Kapur, S; Worthington, A; Tang, Y; Cane, DE; Burkart, MD; Khosla, C,期刊:Bioorganic & Medicinal Chemistry Letters, 页码:3034-3038 , 文章类型: Proceedings Paper,,卷期:2008年18-10]
- The critical role of protein-protein interactions in the chemistry of polyketide synthases is well established. However, the transient and weak nature of these interactions, in particular those involving the acyl carrier...
- Synthesis of diglycosylceramides and evaluation of their iNKT cell stimulatory properties
[作者:Liu, Y; Deng, S; Bai, L; Freigang, S; Mattner, J; Teyton, L; Bendelac, A; Savage, PB,期刊:Bioorganic & Medicinal Chemistry Letters, 页码:3052-3055 , 文章类型: Proceedings Paper,,卷期:2008年18-10]
- Stimulation of iNKT cells is highly dependent on the structures of the glycolipids presented by CD1d. Furthermore, antigen processing and CD1d loading in lysosomes play central roles in controlling the stimulatory proper...
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