- A randomized, double-blind, sham-controlled study of granulocyte/monocyte apheresis for active ulcerative colitis
[作者：Sands, BE; Sandborn, WJ; Feagan, B; Lofberg, R; Hibi, T; Wang, T; Gustofson, LM; Wong, CJ; Vandervoort, MK; Hanauer, S,期刊：Gastroenterology, 页码：400-409 , 文章类型： Article，,卷期：2008年135-2]
- Background & Aims: Activated granulocytes and monocytes/macrophages are implicated in the pathogenesis of ulcerative colitis. Open-label studies and clinical experience in Japan and Europe have suggested that granulocyte...
- Direct activation of cytosolic Ca2+ signaling and enzyme secretion by cholecystokinin in human pancreatic acinar cells
[作者：Murphy, JA; Criddle, DN; Sherwood, M; Chvanov, M; Mukherjee, R; McLaughlin, E; Booth, D; Gerasimenko, JV; Raraty, MGT; Ghaneh, P; Neoptolemos, JP; Gerasimenko, OV; Tepikin, AV; Green, GM; Reeve, JR; Petersen, OH; Sutton, R,期刊：Gastroenterology, 页码：632-641 , 文章类型： Article，,卷期：2008年135-2]
- Background & Aims: Cholecystokinin (CCK) has been thought to act only indirectly on human pancreatic acinar cells via vagal nerve stimulation, rather than by direct CCK receptor activation as on rodent pancreatic acinar ...
- Hepatocyte-specific Smad7 expression attenuates TGF-beta-mediated fibrogenesis and protects against liver damage
[作者：Dooley, S; Hamzavi, J; Ciuclan, L; Godoy, P; Ilkavets, I; Ehnert, S; Ueberham, E; Gebhardt, R; Kanzler, S; Geier, A; Breitkopf, K; Weng, HL; Mertens, PR,期刊：Gastroenterology, 页码：642-659 , 文章类型： Article，,卷期：2008年135-2]
- Background & Aims: The profibrogenic role of transforming growth factor (TGF)-beta in liver has mostly been attributed to hepatic stellate cell activation and excess, matrix synthesis. Hepatocytes are believed to contrib...
- Toll-like receptor signaling in small intestinal epithelium promotes B-cell recruitment and IgA production in lamina propria
[作者：Shang, LM; Fukata, M; Thirunarayanan, N; Martin, AP; Arnaboldi, P; Maussang, D; Berin, C; Unkeless, JC; Mayer, L; Abreu, MT; Lira, SA,期刊：Gastroenterology, 页码：529-538 , 文章类型： Article，,卷期：2008年135-2]
- Background & Aims: Several lines of evidence support a role for Toll-like receptor (TLR) signaling to protect the intestine from pathogenic infection. We hypothesized that TLR signaling at the level of the intestinal epi...
- Raf protects against colitis by promoting mouse colon epithelial cell survival through NF-kappa B
[作者：Edelblum, KL; Washington, MK; Koyama, T; Robine, S; Baccarini, M; Polk, DB,期刊：Gastroenterology, 页码：539-551 , 文章类型： Article，,卷期：2008年135-2]
- Background & Aims: Raf-1 kinase is a key regulator of a number of cellular processes, which promote the maintenance of a healthy colon epithelium. This study addresses the role of Raf in epithelial cell survival in respo...
- Inhibition of integrin alpha v beta 6 on cholangiocytes blocks transforming growth factor-beta activation and retards biliary fibrosis progression
[作者：Patsenker, E; Popov, Y; Stickel, F; Jonczyk, A; Goodman, SL; Schuppan, D,期刊：Gastroenterology, 页码：660-670 , 文章类型： Article，,卷期：2008年135-2]
- Background & Aims: Integrin alpha v beta 6 is highly expressed on certain activated epithelia, where it mediates attachment to fibronectin and serves as coreceptor for the activation of latent transforming growth factor ...
- TL1A (TNFSF15) regulates the development of chronic colitis by modulating both T-helper 1 and T-helper 17 activation
[作者：Takedatsu, H; Michelsen, KS; Wei, B; Landers, CJ; Thomas, LS; Dhall, D; Braun, J; Targan, SR,期刊：Gastroenterology, 页码：552-567 , 文章类型： Article，,卷期：2008年135-2]
- Background & Aims: TL1A is a tumor necrosis factor-like molecule that mediates a strong costimulation of T-helper (T-H) 1 cells. Expression of TL1A is increased in the mucosa of Crohn's disease patients and murine models...
- Platelet-derived growth factor signaling through ephrin-B2 regulates hepatic vascular structure and function
[作者：Semela, D; Das, A; Langer, D; Kang, NL; Leof, E; Shah, V,期刊：Gastroenterology, 页码：671-679 , 文章类型： Article，,卷期：2008年135-2]
- Background & Aims: Cirrhosis is associated with prominent changes in sinusoidal structure and function. Although the resident pericyte in liver, the hepatic stellate cell (HSC), is well characterized in the process of fi...
- Copper availability contributes to iron perturbations in human nonalcoholic fatty liver disease
[作者：Aigner, E; Theurl, I; Haufe, H; Seifert, M; Hohla, F; Scharinger, L; Stickel, F; Mourlane, F; Weiss, G; Datz, C,期刊：Gastroenterology, 页码：680-688 , 文章类型： Article，,卷期：2008年135-2]
- Background & Aims: iron perturbations are frequently observed in nonalcoholic fatty liver disease (NAFLD). We aimed to investigate a potential association of copper status with disturbances of iron homeostasis in NAFLD. ...
- Methylation of the calcium channel-related gene, CACNA2D3, is frequent and a poor prognostic factor in gastric cancer
[作者：Wanajo, A; Sasaki, A; Nagasaki, H; Shimada, S; Otsubo, T; Owaki, S; Shimizu, Y; Eishi, Y; Kojima, K; Nakajima, Y; Kawano, T; Yuasa, Y; Akiyama, Y,期刊：Gastroenterology, 页码：580-590 , 文章类型： Article，,卷期：2008年135-2]
- Background & Aims: The calcium channel voltage-dependent alpha 2 delta subunit consists of 4 genes, CACNA2D1 to CACNA2D4, of which CACNA2D2 and CACNA2D3 are located on 3p21.3 and 3p21.1, respectively. Here, we examined t...
- Regulation of bile acid synthesis by the nuclear receptor Rev-erb alpha
[作者：Duez, H; Van Der Veen, JN; Duhem, C; Pourcet, B; Touvier, T; Fontaine, C; Derudas, B; Bauge, E; Havinga, R; Bloks, VW; Wolters, H; Van Der Sluijs, FH; Vennstrom, B; Kuipers, F; Staels, B,期刊：Gastroenterology, 页码：689-698 , 文章类型： Article，,卷期：2008年135-2]
- Background & Aims: Conversion into bile acids represents an important route to remove excess cholesterol from the body. Rev-erb alpha is a nuclear receptor that participates as one of the clock genes in the control of ci...
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