- Stabilization of beta-catenin induces pancreas tumor formation
[作者：Heiser, PW; Cano, DA; Landsman, L; Kim, GE; Kench, JG; Klimstra, DS; Taketo, MM; Biankin, AV; Hebrok, M,期刊：Gastroenterology, 页码：1288-1300 , 文章类型： Article，,卷期：2008年135-4]
- Background & Aims: beta-Catenin signaling within the canonical Writ pathway is essential for pancreas development. However, the pathway is normally down-regulated in the adult organ. Increased cytoplasmic and nuclear loc...
- Murine embryonic stem cell-derived pancreatic acinar cells recapitulate features of early pancreatic differentiation
[作者：Rovira, M; Delaspre, F; Massumi, M; Serra, SA; Valverde, MA; Lloreta, J; Dufresne, M; Payre, B; Konieczny, SF; Savatier, P; Real, FX; Skoudy, A,期刊：Gastroenterology, 页码：1301-1310 , 文章类型： Article，,卷期：2008年135-4]
- Background & Aims: Acinar cells constitute 90% of the pancreas epithelium, are polarized, and secrete digestive enzymes. These cells play a crucial role in pancreatitis and pancreatic cancer. However, there are limited m...
- Deletion of apoptosis signal-regulating kinase 1 attenuates acetaminophen-induced liver injury by inhibiting c-jun N-terminal kinase activation
[作者：Nakagawa, H; Maeda, S; Hikiba, Y; Ohmae, T; Shibata, W; Yanai, A; Sakamoto, K; Ogura, K; Noguchi, T; Karin, M; Ichijo, H; Omata, M,期刊：Gastroenterology, 页码：1311-1321 , 文章类型： Article，,卷期：2008年135-4]
- Background & Aims: Acetaminophen (APAP) overdose is the most frequent cause of drug-induced liver failure. C-jun N-terminal kinase (JNK) is thought to play a central role in APAP-induced liver injury, although its upstre...
- Genomic and epigenetic instability in colorectal cancer pathogenesis
[作者：Grady, WM; Carethers, JM,期刊：Gastroenterology, 页码：1079-1099 , 文章类型： Review，,卷期：2008年135-4]
- Colorectal cancer arises as a consequence of the accumulation of genetic alterations (gene mutations, gene amplification, and so on) and epigenetic alterations (aberrant DNA methylation, chromatin modifications, and so o...
- E2F1 inhibits c-Myc-driven apoptosis via PIK3CA/Akt/mTOR and COX-2 in a mouse model of human liver cancer
[作者：Ladu, S; Calvisi, DF; Conner, EA; Farina, M; Factor, VM; Thorgeirsson, SS,期刊：Gastroenterology, 页码：1322-1332 , 文章类型： Article，,卷期：2008年135-4]
- Background & Aims: Resistance to apoptosis is essential for cancer growth. We previously reported that hepatic coexpression of c-Myc and E2F1, 2 key regulators of proliferation and apoptosis, enhanced hepatocellular carc...
- Fatal autoimmune hepatitis induced by concurrent loss of naturally arising regulatory T cells and PD-1-mediated signaling
[作者：Kido, M; Watanabe, N; Okazaki, T; Akamatsu, T; Tanaka, J; Saga, K; Nishio, A; Honjo, T; Chiba, T,期刊：Gastroenterology, 页码：1333-1343 , 文章类型： Article，,卷期：2008年135-4]
- Background & Aims: Because of the lack of animal models developing spontaneous autoimmune hepatitis (AIH), the molecular mechanisms involved in the development of AIH are still unclear. This study aims to examine the reg...
- Oxidative inactivation of key mitochondrial proteins leads to dysfunction and injury in hepatic ischemia reperfusion
[作者：Moon, KH; Hood, BL; Mukhopadhyay, P; Rajesh, M; Abdelmegeed, MA; Kwon, YI; Conrads, TP; Veenstra, TD; Song, BJ; Pacher, P,期刊：Gastroenterology, 页码：1344-1357 , 文章类型： Article，,卷期：2008年135-4]
- Background & Aims: Ischemia-reperfusion (I/R) is a major mechanism of liver injury following hepatic surgery or transplantation. Despite numerous reports on the role of oxidative/nitrosative stress and mitochondrial dysf...
- Genetic alteration of Keap1 confers constitutive Nrf2 activation and resistance to chemotherapy in gallbladder cancer
[作者：Shibata, T; Kokubu, A; Gotoh, M; Ojima, H; Ohta, T; Yamamoto, M; Hirohashi, S,期刊：Gastroenterology, 页码：1358-1368 , 文章类型： Article，,卷期：2008年135-4]
- Background & Aims: Biliary tract cancer (BTC) is a highly malignant tumor, and identification of effective therapeutic targets to improve prognosis is urgently required. Oncogenic activation of survival genes is importan...
|