- Crossing the species barrier by PrPSc replication in vitro generates unique infectious Prions
[作者:Castilla, J; Gonzalez-Romero, D; Saa, P; Morales, R; De Castro, J; Soto, C,期刊:Cell, 页码:757-768 , 文章类型: Article,,卷期:2008年134-5]
- Prions are unconventional infectious agents composed exclusively of misfolded prion protein (PrPSc), which transmits the disease by propagating its abnormal conformation to the cellular prion protein (PrPC). A key charac...
- XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease
[作者:Kaser, A; Lee, AH; Franke, A; Glickman, JN; Zeissig, S; Tilg, H; Nieuwenhuis, EES; Higgins, DE; Schreiber, S; Glimcher, LH; Blumberg, RS,期刊:Cell, 页码:743-756 , 文章类型: Article,,卷期:2008年134-5]
- Inflammatory bowel disease (IBD) has been attributed to aberrant mucosal immunity to the intestinal microbiota. The transcription factor XBP1, a key component of the endoplasmic reticulum (ER) stress response, is require...
- HIV envelope-CXCR4 signaling activates cofilin to overcome cortical actin restriction in resting CD4 T cells
[作者:Yoder, A; Yu, DY; Dong, L; Iyer, SR; Xu, XH; Kelly, J; Liu, J; Wang, WF; Vorster, PJ; Agulto, L; Stephany, DA; Cooper, JN; Marsh, JW; Wu, YT,期刊:Cell, 页码:782-792 , 文章类型: Article,,卷期:2008年134-5]
- Binding of the HIV envelope to the chemokine coreceptors triggers membrane fusion and signal transduction. The fusion process has been well characterized, yet the role of coreceptor signaling remains elusive. Here, we de...
- Chemical and biological approaches synergize to ameliorate protein-folding diseases
[作者:Mu, TW; Ong, DST; Wang, YJ; Balch, WE; Yates, JR; Segatori, L; Kelly, JW,期刊:Cell, 页码:769-781 , 文章类型: Article,,卷期:2008年134-5]
- Loss-of-function diseases are often caused by a mutation in a protein traversing the secretory pathway that compromises the normal balance between protein folding, trafficking, and degradation. We demonstrate that the in...
- UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1 alpha turnover
[作者:Alexandru, G; Graumann, J; Smith, GT; Kolawa, NJ; Fang, RH; Deshaies, RJ,期刊:Cell, 页码:804-816 , 文章类型: Article,,卷期:2008年134-5]
- p97 is an ATP-dependent chaperone that plays an important role in endoplasmic reticulum-associated degradation but whose connections to turnover of soluble proteins remain sparse. Binding of p97 to substrates is mediated...
- Structural coupling of SH2-kinase domains links fes and Abl substrate recognition and kinase activation
[作者:Filippakopoulos, P; Kofler, M; Hantschel, O; Gish, GD; Grebien, F; Salah, E; Neudecker, P; Kay, LE; Turk, BE; Superti-Furga, G; Pawson, T; Knapp, S,期刊:Cell, 页码:793-803 , 文章类型: Article,,卷期:2008年134-5]
- The SH2 domain of cytoplasmic tyrosine kinases can enhance catalytic activity and substrate recognition, but the molecular mechanisms by which this is achieved are poorly understood. We have solved the structure of the p...
- Coronin 1B antagonizes cortactin and remodels Arp2/3-containing actin branches in lamellipodia
[作者:Cai, L; Makhov, AM; Schafer, DA; Bear, JE,期刊:Cell, 页码:828-842 , 文章类型: Article,,卷期:2008年134-5]
- The dendritic actin network generated by the Arp2/3 complex in lamellipodia underlies formation of protrusions, directional sensing, and migration. While the generation of this network is well studied, the mechanisms reg...
- Molecular basis for the sorting of the SNARE VAMP7 into endocytic clathrin-coated vesicles by the ArfGAP Hrb
[作者:Pryor, PR; Jackson, L; Gray, SR; Edeling, MA; Thompson, A; Sanderson, CM; Evans, PR; Owen, DJ; Luzio, JP,期刊:Cell, 页码:817-827 , 文章类型: Article,,卷期:2008年134-5]
- SNAREs provide the specificity and energy for the fusion of vesicles with their target membrane, but how they are sorted into the appropriate vesicles on post-Golgi trafficking pathways is largely unknown. We demonstrate...
- In vivo Imaging of oskar mRNA transport reveals the mechanism of posterior localization
[作者:Zimyanin, VL; Belaya, K; Pecreaux, J; Gilchrist, MJ; Clark, A; Davis, I; St Johnston, D,期刊:Cell, 页码:843-853 , 文章类型: Article,,卷期:2008年134-5]
- oskar mRNA localization to the posterior of the Drosophila oocyte defines where the abdomen and germ cells form in the embryo. Although this localization requires microtubules and the plus end-directed motor, kinesin, it...
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