- Bleach Activates a Redox-Regulated Chaperone by Oxidative Protein Unfolding
[作者：Winter, J; Ilbert, M; Graf, PCF; Ozcelik, D; Jakob, U,期刊：Cell, 页码：691-701 , 文章类型： Article，,卷期：2008年135-4]
- Hypochlorous acid (HOCl), the active ingredient in household bleach, is an effective antimicrobial produced by the mammalian host defense to kill invading microorganisms. Despite the widespread use of HOCl, surprisingly ...
- Mistranslation of Membrane Proteins and Two-Component System Activation Trigger Antibiotic-Mediated Cell Death
[作者：Kohanski, MA; Dwyer, DJ; Wierzbowski, J; Cottarel, G; Collins, JJ,期刊：Cell, 页码：679-690 , 文章类型： Article，,卷期：2008年135-4]
- Aminoglycoside antibiotics, such as gentamicin and kanamycin, directly target the ribosome, yet the mechanisms by which these bactericidal drugs induce cell death are not fully understood. Recently, oxidative stress has ...
- Arrestin-Related Ubiquitin-Ligase Adaptors Regulate Endocytosis and Protein Turnover at the Cell Surface
[作者：Lin, CH; MacGum, JA; Chu, T; Stefan, CJ; Emr, SD,期刊：Cell, 页码：714-725 , 文章类型： Article，,卷期：2008年135-4]
- The diversity of plasma membrane (PM) proteins presents a challenge for the achievement of cargo-specific regulation of endocytosis. Here, we describe a family of proteins in yeast (ARTs, for arrestin-related trafficking...
- Regulation of T Cell Receptor Activation by Dynamic Membrane Binding of the CD3 epsilon Cytoplasmic Tyrosine-Based Motif
[作者：Xu, CQ; Gagnon, E; Call, ME; Schnell, JR; Schwieters, CD; Carman, CV; Chou, JJ; Wucherpfennig, KW,期刊：Cell, 页码：702-713 , 文章类型： Article，,卷期：2008年135-4]
- Many immune system receptors signal through cytoplasmic tyrosine-based motifs (ITAMs), but how receptor ligation results in ITAM phosphorylation remains unknown. Live-cell imaging studies showed a close interaction of th...
- A Translational Profiling Approach for the Molecular Characterization of CNS Cell Types
[作者：Heiman, M; Schaefer, A; Gong, S; Peterson, JD; Day, M; Ramsey, KE; Suarez-Farinas, M; Schwarz, C; Stephan, DA; Surmeier, DJ; Greengard, P; Heintz, N,期刊：Cell, 页码：738-748 , 文章类型： Article，,卷期：2008年135-4]
- The cellular heterogeneity of the brain confounds efforts to elucidate the biological properties of distinct neuronal populations. Using bacterial artificial chromosome (BAC) transgenic mice that express EGFP-tagged ribo...
- FLO1 Is a Variable Green Beard Gene that Drives Biofilm-like Cooperation in Budding Yeast
[作者：Smukalla, S; Caldara, M; Pochet, N; Beauvais, A; Guadagnini, S; Yan, C; Vinces, MD; Jansen, A; Prevost, MC; Latge, JP; Fink, GR; Foster, KR; Verstrepen, KJ,期刊：Cell, 页码：726-737 , 文章类型： Article，,卷期：2008年135-4]
- The budding yeast, Saccharomyces cerevisiae, has emerged as an archetype of eukaryotic cell biology. Here we show that S. cerevisiae is also a model for the evolution of cooperative behavior by revisiting flocculation, a...
- Telomerase Reverse Transcriptase Delays Aging in Cancer-Resistant Mice
[作者：Tomas-Loba, A; Flores, I; Fernandez-Marcos, PJ; Cayuela, ML; Maraver, A; Tejera, A; Borras, C; Matheu, A; Klatt, P; Flores, JM; Vina, J; Serrano, M; Blasco, MA,期刊：Cell, 页码：609-622 , 文章类型： Article，,卷期：2008年135-4]
- Telomerase confers limitless proliferative potential to most human cells through its ability to elongate telomeres, the natural ends of chromosomes, which otherwise would undergo progressive attrition and eventually comp...
- Structural Synergy and Molecular Crosstalk between Bacterial Helicase Loaders and Replication Initiators
[作者：Mott, ML; Erzberger, JP; Coons, MM; Berger, JM,期刊：Cell, 页码：623-634 , 文章类型： Article，,卷期：2008年135-4]
- The loading of oligomeric helicases onto replication origins marks an essential step in replisome assembly. In cells, dedicated AAA+ ATPases regulate loading, however, the mechanism by which these factors recruit and dep...
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