- The RNA Polymerase "Switch Region" Is a Target for Inhibitors
[作者：Mukhopadhyay, J; Das, K; Ismail, S; Koppstein, D; Jang, MY; Hudson, B; Sarafianos, S; Tuske, S; Patel, J; Jansen, R; Irschik, H; Arnold, E; Ebright, RH,期刊：Cell, 页码：295-307 , 文章类型： Article，,卷期：2008年135-2]
- The alpha-pyrone antibiotic myxopyronin (Myx) inhibits bacterial RNA polymerase (RNAP). Here, through a combination of genetic, biochemical, and structural approaches, we show that Myx interacts with the RNAP "switch reg...
- Lrp4 Is a Receptor for Agrin and Forms a Complex with MuSK
[作者：Kim, N; Stiegler, AL; Cameron, TO; Hallock, PT; Gomez, AM; Huang, JH; Hubbard, SR; Dustin, ML; Burden, SJ,期刊：Cell, 页码：334-342 , 文章类型： Article，,卷期：2008年135-2]
- Neuromuscular synapse formation requires a complex exchange of signals between motor neurons and skeletal muscle fibers, leading to the accumulation of postsynaptic proteins, including acetylcholine receptors in the musc...
- Fibrils Connect Microtubule Tips with Kinetochores: A Mechanism to Couple Tubulin Dynamics to Chromosome Motion
[作者：McIntosh, JR; Grishchuk, EL; Morphew, MK; Efremov, AK; Zhudenkov, K; Volkov, VA; Cheeseman, IM; Desai, A; Mastronarde, DN; Ataullakhanov, FI,期刊：Cell, 页码：322-333 , 文章类型： Article，,卷期：2008年135-2]
- Kinetochores of mitotic chromosomes are coupled to spindle microtubules in ways that allow the energy from tubulin dynamics to drive chromosome motion. Most kinetochore-associated microtubule ends display curving "protof...
- Mammalian 26S Proteasomes Remain Intact during Protein Degradation
[作者：Kriegenburg, F; Seeger, M; Saeki, Y; Tanaka, K; Lauridsen, AMB; Hartmann-Petersen, R; Hendil, KB,期刊：Cell, 页码：355-365 , 文章类型： Editorial Material，,卷期：2008年135-2]
- It has been suggested that degradation of polyubiquitylated proteins is coupled to dissociation of 26S proteasomes. In contrast, using several independent types of experiments, we find that mammalian proteasomes can degr...
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