- Therapeutic potential of peroxisome proliferators-activated receptor-alpha/gamma dual agonist with alleviation of endoplasmic reticulum stress for the treatment of diabetes
[作者：Han, KL; Choi, JS; Lee, JY; Song, J; Joe, MK; Jung, MH; Hwang, JK,期刊：Diabetes, 页码：737-745 , 文章类型： Article，,卷期：2008年57-3]
- OBJECTIVE-Peroxisome proliferator-activated receptor (PPAR) alpha/gamma dual agonists have the potential to be used as therapeutic agents for the treatment of type 2 diabetes. This study evaluated the function of macelig...
- Resistin impairs insulin-evoked vasodilation
[作者：Gentile, MT; Vecchione, C; Marino, G; Aretini, A; Di Pardo, A; Antenucci, G; Maffei, A; Cifelli, G; Lorio, L; Landolfi, A; Frati, G; Lembo, G,期刊：Diabetes, 页码：577-583 , 文章类型： Article，,卷期：2008年57-3]
- OBJECTIVE-Since vascular dysfunction is a main trait of obese subjects, in the present study we evaluated the vascular impact of resistin, a recently discovered hormone markedly increased in obesity.RESEARCH DESIGN AND M...
- Evidence of an influence of a polymorphism near the INSIG2 on weight loss during a lifestyle intervention in obese children and adolescents
[作者：Reinehr, T; Hinney, A; Nguyen, TT; Hebebrand, J,期刊：Diabetes, 页码：623-626 , 文章类型： Article，,卷期：2008年57-3]
- OBJECTIVE-Homozygotes for the C-allele of the single nucleotide polymorphism (SNP) rs7566605, located similar to 10 kb upstream of insulin-induced gene 2 (INSIG2), showed a slightly increased risk of becoming obese. The ...
- Reduced immunogenicity of first-trimester human fetal pancreas
[作者：Brands, K; Colvin, E; Williams, LJ; Wang, R; Lock, RB; Tuch, BE,期刊：Diabetes, 页码：627-634 , 文章类型： Article，,卷期：2008年57-3]
- OBJECTIVE-The use of human fetal pancreatic tissue may provide a potential source of transplantable P-cells as a therapy for type I diabetes. Human fetal pancreas has a remarkable capacity to grow and differentiate in vi...
- Different brain responses to hypoglycemia induced by equipotent doses of the long-acting insulin analog detemir and human regular insulin in humans
[作者：Rossetti, P; Porcellati, F; Ricci, NB; Candeloro, P; Cioll, P; Bolli, GB; Fanelli, CG,期刊：Diabetes, 页码：746-756 , 文章类型： Article，,卷期：2008年57-3]
- OBJECTIVE-The acylated long-acting insulin analog detemir is more lipophilic than human insulin and likely crosses the blood-to-brain barrier more easily than does human insulin. The aim of these studies was to assess th...
- Reversal of streptozotocin-induced diabetes in mice by cellular transduction with recombinant pancreatic transcription factor pancreatic duodenal homeobox-1 - A novel protein transduction domain-based therapy
[作者：Koya, V; Lu, S; Sun, YP; Purich, DL; Atkinson, MA; Yang, LJ,期刊：Diabetes, 页码：757-769 , 文章类型： Article，,卷期：2008年57-3]
- OBJECTIVE-The key pancreatic transcription factor pancreatic duodenal homeobox-1 (Pdx1), known to control development and maintenance of pancreatic P-cells, possesses a protein transduction domain (PTD) that facilitates ...
- Increasing GLP-1-induced beta-cell proliferation by silencing the negative regulators of signaling cAMP response element modulator-alpha and DUSP14
[作者：Klinger, S; Poussin, C; Debril, MB; Dolci, W; Halban, PA; Thorens, B,期刊：Diabetes, 页码：584-593 , 文章类型： Article，,卷期：2008年57-3]
- OBJECTIVE-Glucagon-like peptide-1 (GLP-1) is a growth and differentiation factor for mature beta-cells and their precursors. However, the overall effect of GLP-1 on increasing beta-cell mass in both in vivo and in vitro ...
- The repression of IRS2 gene by ATF3, a stress-inducible gene, contributes to pancreatic beta-cell apoptosis
[作者：Li, D; Yin, X; Zmuda, EJ; Wolford, CC; Dong, XC; White, MF; Hail, T,期刊：Diabetes, 页码：635-644 , 文章类型： Article，,卷期：2008年57-3]
- OBJECTIVE-P-Cell failure is an essential component of all types of diabetes, and the insulin receptor substrate 2 (IRS2) branch of signaling plays a key role in beta-cell survival and function. We tested the hypothesis t...
- Predictors of incretin concentrations in subjects with normal, impaired, and diabetic glucose tolerance
[作者：Vollmer, K; Holst, JJ; Baher, B; Ellrichmann, M; Nauck, MA; Schmidt, WE; Meier, JJ,期刊：Diabetes, 页码：678-687 , 文章类型： Article，,卷期：2008年57-3]
- OBJECTIVE-Defects in glucagon-like peptide 1 (GLP-1) secretion have been reported in some patients with type 2 diabetes after meal ingestion. We addressed the following questions: 1) Is the quantitative impairment in GLP...
- The effect of cyclooxygenase-2 inhibition on renal. Hemodynamic function in humans with type 1 diabetes
[作者：Cherney, DZI; Miller, JA; Scholey, JW; Bradley, TJ; Slorach, C; Curtis, JR; Dekker, MG; Nasrallah, R; Wbert, RL; Sochett, EB,期刊：Diabetes, 页码：688-695 , 文章类型： Article，,卷期：2008年57-3]
- OBJECTIVE-Studies in animal models suggest that cyclooxygenase-2 (COX2) plays a role in the regulation of the renal microcirculation in diabetes. Accordingly, we examined the role of COX2 in the control of renal hemodyna...
- Analysis of single nucleotide polymorphisms identifies major type 1A diabetes locus telomeric of the major histocompatibility complex
[作者：Aly, TA; Baschal, EE; Jahromi, MM; Fernando, MS; Babu, SR; Fingerlin, TE; Kretowski, A; Erlich, HA; Fain, PR; Rewers, MJ; Eisenbarth, GS,期刊：Diabetes, 页码：770-776 , 文章类型： Article，,卷期：2008年57-3]
- OBJECTIVE-HLA-DRB1*03-DQBI*0201/DRB1*04-DQB1*0302 (DR3/4-DQ8) siblings who share both major histocompatibility complex (MHC) haplotypes identical-by-descent with their proband siblings have a higher risk for type 1A diab...
- Genetic variation and association analyses of the nuclear respiratory factor 1 (nRF1) gene in Chinese patients with type 2 diabetes
[作者：Liu, Y; Niu, N; Zhu, X; Du, T; Wang, X; Chen, D; Wu, X; Gu, HF; Liu, Y,期刊：Diabetes, 页码：777-782 , 文章类型： Article，,卷期：2008年57-3]
- OBJECTIVE-Nuclear respiratory factor I (NRF1) is a strong biological and positional candidate to contribute to type 2 diabetes susceptibility. This study aimed at evaluating associations between NRF1 genetic polymorphism...
- Identification and replication of a novel obesity locus on chromosome 1q24 in isolated populations of Cilento
[作者：Ciullo, M; Nutile, T; Dalmasso, C; Sorice, R; Bellenguez, C; Colonna, V; Persico, MG; Bourgain, C,期刊：Diabetes, 页码：783-790 , 文章类型： Article，,卷期：2008年57-3]
- OBJECTIVE-Obesity is a complex trait with a variety of genetic susceptibility variants. Several loci linked to obesity and/or obesity-related traits have been identified, and relatively few regions have been replicated. ...
- Association of CDKAL1, IGF2BP2, CDKN2A/B, HHEX, SLC30A8, and KCNJ11 with susceptibility to type 2 diabetes in a Japanese population
[作者：Mori, S; Tanaka, Y; Takahashi, A; Hirose, H; Kashiwagi, A; Kaku, K; Kawamori, R; Nakamura, Y; Maeda, S,期刊：Diabetes, 页码：791-795 , 文章类型： Article，,卷期：2008年57-3]
- OBJECTIVE-Recently, several genes have been shown to be associated with an increased risk of type 2 diabetes by genome wide association studies in white populations. To further investigate the involvement of these polymo...
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