- Sodium hydrogen exchanger and phospholipase D are required for alpha(1)-adrenergic receptor stimulation of metalloproteinase-9 and cellular invasion in CCL39 fibroblasts
[作者:Taves, J; Rastedt, D; Canine, J; Mork, D; Wallert, MA; Provost, JJ,期刊:Archives of Biochemistry and Biophysics , 页码:60-66 , 文章类型: Article,,卷期:2008年477-1]
- Matrix metalloproteinase 9 (MMP-9) plays a critical role in digesting the extracellular matrix and has a vital function in tumor metastasis and invasion; this protease activity is significantly increased in non-small cel...
- SOD-like activity of Mn(II) beta-octabromo-meso-tetrakis(N-methylpyridinium-3-yl)-porphyrin equals that of the enzyme itself
[作者:DeFreitas-Silva, G; Reboucas, JS; Spasojevic, I; Benov, L; Idemori, YM; Batinic-Haberle, I,期刊:Archives of Biochemistry and Biophysics , 页码:105-112 , 文章类型: Article,,卷期:2008年477-1]
- Mn porphyrins are among the most efficient SOD mimics with potency approaching that of SOD enzymes. The most potent ones, Mn(III) N-alkylpyridylporphyrins bear positive charges in a close proximity to the metal site, aff...
- High affinity Zn2+ inhibitory site(s) for the trypsin-like peptidase of the 20S proteasome
[作者:Chouduri, AU; Mishina, K; Shimizu, T; Yamazaki, M; Tokumoto, T; Yamada, S,期刊:Archives of Biochemistry and Biophysics , 页码:113-120 , 文章类型: Article,,卷期:2008年477-1]
- The effect of Zn2+ on three major peptidase activities of the 20S proteasome purified from Xenopus oocytes was kinetically investigated. An extremely low concentration of Zn2+ (mu M range) strongly inhibited the trypsin-...
- Photo-crosslinking of proteins in intact cells reveals a dimeric structure of cyclooxygenase-2 and an inhibitor-sensitive oligomeric structure of microsomal prostaglandin E-2 synthase-1
[作者:Hetu, PO; Ouellet, M; Falgueyret, JP; Ramachandran, C; Robichaud, J; Zamboni, R; Riendeau, D,期刊:Archives of Biochemistry and Biophysics , 页码:155-162 , 文章类型: Article,,卷期:2008年477-1]
- We have characterized the structures of cyclooxygenase-2 (COX-2) and microsomal prostaglandin E-2 synthase-1 (mPGES-1) in intact cells using bifunctional and photo-activatable crosslinking agents. A dimeric complex was d...
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