- Severe Tuberculosis Induces Unbalanced Up-Regulation of Gene Networks and Overexpression of IL-22, MIP-1 alpha, CCL27, IP-10, CCR4, CCR5, CXCR3, PD1, PDL2, IL-3, IFN-beta, TIM1, and TLR2 but Low Antigen-Specific Cellular Responses
[作者:Qiu, LY; Huang, D; Chen, CY; Wang, R; Shen, L; Shen, Y; Hunt, R; Estep, J; Haynes, BF; Jacobs, WR; Letvin, NL; Du, G; Chen, ZW,期刊:Journal of Infectious Diseases, 页码:1514-1519 , 文章类型: Article,,卷期:2008年198-10]
- The immune mechanisms by which early host-mycobacterium interaction leads to the development of severe tuberculosis (TB) remain poorly characterized in humans. Here, we demonstrate that severe TB in juvenile rhesus monke...
- Murine Model to Study the Invasion and Survival of Mycobacterium tuberculosis in the Central Nervous System
[作者:Be, NA; Lamichhane, G; Grosset, J; Tyagi, S; Cheng, QJ; Kim, KS; Bishai, WR; Jain, SK,期刊:Journal of Infectious Diseases, 页码:1520-1528 , 文章类型: Article,,卷期:2008年198-10]
- Background. Tuberculosis of the central nervous system (CNS) is a serious, often fatal disease primarily affecting young children. It develops after hematogenous dissemination and subsequent invasion of the CNS by Mycoba...
- Premature Apoptosis of Chlamydia-Infected Cells Disrupts Chlamydial Development
[作者:Ying, SM; Pettengill, M; Latham, ER; Walch, A; Ojcius, DM; Hacker, G,期刊:Journal of Infectious Diseases, 页码:1536-1544 , 文章类型: Article,,卷期:2008年198-10]
- The obligate intracellular development of Chlamydia suggests that the bacteria should be vulnerable to premature host cell apoptosis, but because Chlamydia-infected cells are apoptosis resistant, this has never been able...
- Rapid Increase in the Prevalence of Sulfadoxine-Pyrimethamine Resistance among Plasmodium falciparum Isolated from Pregnant Women in Ghana
[作者:Mockenhaupt, FP; Bedu-Addo, G; Eggelte, TA; Hommerich, L; Holmberg, V; von Oertzen, C; Bienzle, U,期刊:Journal of Infectious Diseases, 页码:1545-1549 , 文章类型: Article,,卷期:2008年198-10]
- Use of intermittent preventive treatment with sulfadoxine-pyrimethamine (SP) during pregnancy (IPTp-SP) has become policy in much of sub-Saharan Africa but crucially depends on the efficacy of SP. We assessed the frequen...
- Plasma Folate Level and High-Dose Folate Supplementation Predict Sulfadoxine-Pyrimethamine Treatment Failure in Pregnant Women in Western Kenya Who Have Uncomplicated Malaria
[作者:van Eijk, AM; Ouma, PO; Williamson, J; Ter Kuile, FO; Parise, M; Otieno, K; Hamel, MJ; Ayisi, JG; Kariuki, S; Kager, PA; Slutsker, L,期刊:Journal of Infectious Diseases, 页码:1550-1553 , 文章类型: Article,,卷期:2008年198-10]
- Sulfadoxine-pyrimethamine (SP) inhibits folate metabolism by the malaria parasite. We investigated the association between folate levels and SP failure in pregnant women. Data from a trial to assess the effect that folat...
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