- Trp(359) regulates flavin thermodynamics and coenzyme selectivity in Mycobacterium tuberculosis FprA
[作者:Neeli, R; Sabri, M; McLean, KJ; Dunford, AJ; Scrutton, NS; Leys, D; Munro, AW,期刊:Biochemical Journal, 页码:563-570 , 文章类型: Article,,卷期:2008年411-3]
- Mtb (Mycobacterium tuberculosis) FprA (flavoprotein reductase A) is an NAD(P)H-dependent FAD-binding reductase that is structurally related to mammalian adrenodoxin reductase, and which supports the catalytic function of...
- Structure and Cu(I)-binding properties of the N-terminal soluble domains of Bacillus subtilis CopA
[作者:Singleton, C; Banci, L; Ciofi-Baffoni, S; Tenori, L; Kihlken, MA; Boetzel, R; Le Brun, NE,期刊:Biochemical Journal, 页码:571-579 , 文章类型: Article,,卷期:2008年411-3]
- CopA, a P-type ATPase from Bacillus subtilis, plays a major role in the resistance of the cell to copper by effecting the export of the metal across the cytoplasmic membrane. The N-terminus of the protein features two so...
- A CD study of uncoupling protein-1 and its transmembrane and matrix-loop domains
[作者:Jelokhani-Niaraki, M; Ivanova, MV; McIntyre, BL; Newman, CL; McSorley, FR; Young, EK; Smith, MD,期刊:Biochemical Journal, 页码:593-603 , 文章类型: Article,,卷期:2008年411-3]
- Conformations of the prototypic UCP-1 (uncoupling protein-1) and its TM (transmembrane) and ML (matrix-loop) domains were studied by CD spectroscopy. Recombinant, untagged mouse UCP-1 and a hexahistidine-tagged version o...
- Interaction of acetylcholinesterase with the G4 domain of the laminin alpha 1-chain
[作者:Johnson, G; Swart, C; Moore, SW,期刊:Biochemical Journal, 页码:507-514 , 文章类型: Article,,卷期:2008年411-3]
- Although the primary function of AChE (acetylcholinesterase) is the synaptic hydrolysis of acetylcholine, it appears that the protein is also able to promote various non-cholinergic activities, including cell adhesion, n...
- G(q)-dependent signalling by the lysophosphatidic acid receptor LPA(3) in gastric smooth muscle: reciprocal regulation of MYPT1 phosphorylation by Rho kinase and cAMP-independent PKA
[作者:Sriwai, W; Zhou, HP; Murthy, KS,期刊:Biochemical Journal, 页码:543-551 , 文章类型: Article,,卷期:2008年411-3]
- The present study characterized the signalling pathways initiated by the bioactive lipid, LPA (lysophosphatidic acid) in smooth muscle. Expression of LPA(3) receptors, but not LPA, and LPA, receptors was demonstrated by ...
- ArHsp21, a developmentally regulated small heat-shock protein synthesized in diapausing embryos of Artemia franciscana
[作者:Qu, ZJ; MacRae, TH,期刊:Biochemical Journal, 页码:605-611 , 文章类型: Article,,卷期:2008年411-3]
- Embryos of the crustacean, Artemia franciscana, undergo alternative developmental pathways, producing either larvae or encysted embryos (cysts). The cysts enter diapause, characterized by exceptionally high resistance to...
- The Ser(186) phospho-acceptor site within ERK4 is essential for its ability to interact with and activate PRAK/MK5
[作者:Perander, M; Aberg, E; Johansen, B; Dreyer, B; Guldvik, IJ; Outzen, H; Keyse, SM; Seternes, OM,期刊:Biochemical Journal, 页码:613-622 , 文章类型: Article,,卷期:2008年411-3]
- ERK (extracellular-signal-regulated kinase) 4 [MAPK (mitogen-activated protein kinase) 4] and ERK3 (MAPK6) are atypical MAPKs. One major difference between these proteins and the classical MAPKs is substitution of the co...
- Ubiquitin-mediated proteasomal degradation of non-synonymous SNP variants of human ABC transporter ABCG2
[作者:Nakagawa, H; Tamura, A; Wakabayashi, K; Hoshijima, K; Komada, M; Yoshida, T; Kometani, S; Matsubara, T; Mikuriya, K; Ishikawa, T,期刊:Biochemical Journal, 页码:623-631 , 文章类型: Article,,卷期:2008年411-3]
- Clinical relevance is implicated between the genetic polymorphisms of the ABC (ATP-binding cassette) transporter ABCG2 (ABC subfamily G, member 2) and the individual differences in drug response. We expressed a total of ...
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