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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共38条记录   Overindulgence and metabolic syndrome: is FoxO1 a missing link? [作者：Sparks, JD; Sparks, CE,期刊：Journal of clinical investigation, 页码：2012-2015 , 文章类型： Editorial Material，,卷期：2008年118-6] Excessive production of triglyceride-rich VLDL, which can result from dietary overindulgence, underlies metabolic syndrome - a combination of disorders including high blood pressure, obesity, high triglyceride, and insul... Regulation of A beta pathology by beclin 1: a protective role for autophagy? [作者：Lee, JA; Gao, FB,期刊：Journal of clinical investigation, 页码：2015-2018 , 文章类型： Editorial Material，,卷期：2008年118-6] The amyloid beta (A beta) peptide is thought to be a major culprit in Alzheimer disease (AD), and its production and degradation have been intensely investigated. Nevertheless, it remains largely unknown how A beta patho... A signaling pathway AKTing up in schizophrenia [作者：Arguello, PA; Gogos, JA,期刊：Journal of clinical investigation, 页码：2018-2021 , 文章类型： Editorial Material，,卷期：2008年118-6] The serine/threonine protein kinase AKT (also known as PKB) signaling pathway has been associated with several human diseases, including schizophrenia. Studies in preclinical models have demonstrated that impaired AKT si... Is CD133 a marker Of metastatic colon cancer stem cells? [作者：LaBarge, MA; Bissell, MJ,期刊：Journal of clinical investigation, 页码：2021-2024 , 文章类型： Editorial Material，,卷期：2008年118-6] The concept of the so-called cancer stem cell (CSC) holds that only a minority of cells within a tumor have the ability to generate a new tumor. Over the last decade, a large body of literature has implicated the protein... To kill a tumor cell: the potential of proapoptotic receptor agonists [作者：Ashkenazi, A; Herbst, RS,期刊：Journal of clinical investigation, 页码：1979-1990 , 文章类型： Review，,卷期：2008年118-6] Disturbances in mechanisms that direct abnormal cells to undergo apoptosis frequently and critically contribute to tumorigenesis, yielding a logical target for potential therapeutic intervention. There is currently heigh... The anticancer immune response: indispensable for therapeutic success? [作者：Zitvogel, L; Apetoh, L; Ghiringhelli, F; Andre, F; Tesniere, A; Kroemer, G,期刊：Journal of clinical investigation, 页码：1991-2001 , 文章类型： Review，,卷期：2008年118-6] Although the impact of tumor immunology on the clinical management of most cancers is still negligible, there is increasing evidence that anticancer immune responses may contribute to the control of cancer after conventi... Pathogen destruction versus intracellular survival: the role of lipids as phagosomal fate determinants [作者：Steinberg, BE; Grinstein, S,期刊：Journal of clinical investigation, 页码：2002-2011 , 文章类型： Review，,卷期：2008年118-6] Phagocytosis is a key component of the innate immune response and of the clearance of apoptotic bodies. Phagosome formation and subsequent maturation require extensive cytoskeletal rearrangement and precisely choreograph... Science rides the online wave [作者：Honey, K,期刊：Journal of clinical investigation, 页码：1976-1976 , 文章类型： News Item，,卷期：2008年118-6] Impaired parasympathetic function increases susceptibility to inflammatory bowel disease in a mouse model of depression [作者：Ghia, JE; Blennerhassett, P; Collins, SM,期刊：Journal of clinical investigation, 页码：2209-2218 , 文章类型： Article，,卷期：2008年118-6] Clinical and experimental evidence indicates that intestinal inflammatory conditions can be exacerbated by behavioral conditions such as depression. The recent demonstration of a tonic counterinflammatory influence media... The E1784K mutation in SCN5A is associated with mixed clinical phenotype of type 3 long QT syndrome [作者：Makita, N; Behr, E; Shimizu, W; Horie, M; Sunami, A; Crotti, L; Schulze-Bahr, E; Fukuhara, S; Mochizuki, N; Makiyama, T; Itoh, H; Christiansen, M; McKeown, P; Miyamoto, K; Kamakura, S; Tsutsui, H; Schwartz, PJ; George, AL; Roden, DM,期刊：Journal of clinical investigation, 页码：2219-2229 , 文章类型： Article，,卷期：2008年118-6] Phenotypic overlap of type 3 long QT syndrome (LQT3) with Brugada syndrome (BrS) is observed in some carriers of mutations in the Na channel SCN5A. While this overlap is important for patient management, the clinical fea... Leaky Ca2+ release channel/ryanodine receptor 2 causes seizures and sudden cardiac death in mice [作者：Lehnart, SE; Mongillo, M; Bellinger, A; Lindegger, N; Chen, BX; Hsueh, W; Reiken, S; Wronska, A; Drew, LJ; Ward, CW; Lederer, WJ; Kass, RS; Morley, G; Marks, AR,期刊：Journal of clinical investigation, 页码：2230-2245 , 文章类型： Article，,卷期：2008年118-6] The Ca2+ release channel ryanodine receptor 2 (RyR2) is required for excitation-contraction coupling in the heart and is also present in the brain. Mutations in RyR2 have been linked to exercise-induced sudden cardiac de... Mechanisms of cardiac arrhythmias and sudden death in transgenic rabbits with long QT syndrome [作者：Brunner, M; Peng, XW; Liu, GX; Ren, XQ; Ziv, O; Choi, BR; Mathur, R; Hajjiri, M; Odening, KE; Steinberg, E; Folco, EJ; Pringa, E; Centracchio, J; Macharzina, RR; Donahay, T; Schofield, L; Rana, N; Kirk, M; Mitchell, GF; Poppas, A; Zehender, M; Koren, G,期刊：Journal of clinical investigation, 页码：2246-2259 , 文章类型： Article，,卷期：2008年118-6] Long QT syndrome (LQTS) is a heritable disease associated with ECG QT interval prolongation, ventricular tachycardia, and sudden cardiac death in young patients. Among genotyped individuals, mutations in genes encoding r... Sodium channel beta 1 subunit mutations associated with Brugada syndrome and cardiac conduction disease in humans [作者：Watanabe, H; Koopmann, TT; Le Scouarnec, S; Yang, T; Ingram, CR; Schott, JJ; Demolombe, S; Probst, V; Anselme, F; Escande, D; Wiesfeld, ACP; Pfeufer, A; Kaab, S; Wichmann, HE; Hasdemir, C; Aizawa, Y; Wilde, AAM; Roden, DM; Bezzina, CR,期刊：Journal of clinical investigation, 页码：2260-2268 , 文章类型： Article，,卷期：2008年118-6] Brugada syndrome is a genetic disease associated with sudden cardiac death that is characterized by ventricular fibrillation and right precordial ST segment elevation on ECG. Loss-of-function mutations in SCN5A, which en... Unique CD14(+) intestinal macrophages contribute to the pathogenesis of Crohn disease via lL-23/IFN-gamma axis [作者：Kamada, N; Hisamatsu, T; Okamoto, S; Chinen, H; Kobayashi, T; Sato, T; Sakuraba, A; Kitazume, MT; Sugita, A; Koganei, K; Akagawa, KS; Hibi, T,期刊：Journal of clinical investigation, 页码：2269-2280 , 文章类型： Article，,卷期：2008年118-6] Intestinal macrophages play a central role in regulation of immune responses against commensal bacteria. In general, intestinal macrophages lack the expression of innate-immune receptor CD14 and do not produce pro-inflam... Niernann-Pick C1 protects against atherosclerosis in mice via regulation of macrophage intracellular cholesterol trafficking [作者：Zhang, JR; Coleman, T; Langmade, SJ; Scherrer, DE; Lane, L; Lanier, MH; Feng, C; Sands, MS; Schaffer, JE; Semenkovich, CF; Ory, DS,期刊：Journal of clinical investigation, 页码：2281-2290 , 文章类型： Article，,卷期：2008年118-6] Niemann-Pick C1 (NPC1) is a key participant in cellular cholesterol trafficking. Loss of NPC1 function leads to defective suppression of SREBP-dependent gene expression and failure to appropriately activate liver X recep... Vasoinhibins prevent retinal vasopermeability associated with diabetic retinopathy in rats via protein phosphatase 2A-dependent eNOS inactivation [作者：Garcia, C; Aranda, J; Arnold, E; Thebault, S; Macotela, Y; Lopez-Casillas, F; Mendoza, V; Quiroz-Mercado, H; Hernandez-Montiel, HL; Lin, SH; de la Escalera, GM; Clapp, C,期刊：Journal of clinical investigation, 页码：2291-2300 , 文章类型： Article，,卷期：2008年118-6] Increased retinal vasopermeability contributes to diabetic retinopathy, the leading cause of blindness in working-age adults. Despite clinical progress, effective therapy remains a major need. Vasoinhibins, a family of p...