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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共36条记录   Sex differences in thrombosis in mice are mediated by sex-specific growth hormone secretion patterns [作者：Wong, JH; Dukes, J; Levy, RE; Sos, B; Mason, SE; Fong, TS; Weiss, EJ,期刊：Journal of clinical investigation, 页码：2969-2978 , 文章类型： Article，,卷期：2008年118-8] Sex differences in thrombosis are well described, but their underlying mechanism(s) are not completely understood. Coagulation proteins are synthesized in the liver, and liver gene expression is sex specific and depends ... Noninvasive diagnosis of ruptured peripheral atherosclerotic lesions and myocardial infarction by antibody profiling [作者：Cleutjens, KBJM; Faber, BCG; Rousch, M; van Doorn, R; Hackeng, TM; Vink, C; Geusens, P; ten Cate, H; Waltenberger, J; Tchaikovski, V; Lobbes, M; Somers, V; Sijbers, A; Black, D; Kitslaar, PJEHM; Daemen, MJAP,期刊：Journal of clinical investigation, 页码：2979-2985 , 文章类型： Article，,卷期：2008年118-8] Novel biomarkers, such as circulating (auto)antibody signatures, may improve early detection and treatment of ruptured atherosclerotic lesions and accompanying cardiovascular events, such as myocardial infarction. Using ... Dopamine 5 receptor mediates Ang II type 1 receptor degradation via a ubiquitin-proteasome pathway in mice and human cells (vol 118, pg 2180, 2008) [作者：Li, HW; Armando, I; Yu, PY; Escano, C; Mueller, SC; Asico, L; Pascua, A; Lu, QS; Wang, XY; Villar, VAM; Jones, JE; Wang, Z; Periasamy, A; Lau, YS; Soares-Da-Silva, P; Creswell, K; Guillemette, G; Sibley, DR; Eisner, G; Gildea, JJ; Felder, RA; Jose, PA,期刊：Journal of clinical investigation, 页码：2986-2986 , 文章类型： Correction，,卷期：2008年118-8] Phosphorylation of GSK-3 beta by cGMP-dependent protein kinase II promotes hypertrophic differentiation of murine chondrocytes (vol 118, pg 2506, 2008) [作者：Kawasaki, Y; Kugimiya, F; Chikuda, H; Kamekura, S; Ikeda, T; Kawamura, N; Saito, T; Shinoda, Y; Higashikawa, A; Yano, F; Ogasawara, T; Ogata, N; Hoshi, K; Hofmann, F; Woodgett, JR; Nakamura, K; Chung, UI; Kawaguchi, H,期刊：Journal of clinical investigation, 页码：2986-2986 , 文章类型： Correction，,卷期：2008年118-8] Novel antibody markers of unstable atherosclerotic lesions [作者：Bloch, DB; Wang, TJ; Gerszten, RE,期刊：Journal of clinical investigation, 页码：2675-2677 , 文章类型： Editorial Material，,卷期：2008年118-8] Detection of autoantibodies in human serum assists in the diagnosis of patients with autoimmune diseases. Diagnostic antibody signatures have also been proposed for colon, pancreatic, and breast cancers. In this issue of... Fc receptors in immune thrombocytopenias: a target for immunomodulation? [作者：Psaila, B; Bussel, JB,期刊：Journal of clinical investigation, 页码：2677-2681 , 文章类型： Editorial Material，,卷期：2008年118-8] In autoimmune disease, Fc receptors (FcRs) form the interface between immune effector cells and their antibody-coated targets, and as such are attractive targets for immunomodulatory therapy. In this issue of the JCI, tw... Fifty years later: the disk goes to the prom [作者：Kleinman, ME; Ambati, J,期刊：Journal of clinical investigation, 页码：2681-2684 , 文章类型： Editorial Material，,卷期：2008年118-8] Although age-related macular degeneration is the most prevalent macular disease in the world, numerous discoveries regarding the molecular bases of vision have been made through genetic association studies of rare inheri... Marking a path to transplant tolerance [作者：Seyfert-Margolis, V; Turka, LA,期刊：Journal of clinical investigation, 页码：2684-2686 , 文章类型： Editorial Material，,卷期：2008年118-8] Long-term allograft survival requires lifelong immunosuppression, which comes with serious side effects. Inducing immune tolerance to the transplant would enable immunosuppression withdrawal and revolutionize the quality... Immune response hinders therapy for lysosomal storage diseases [作者：Ponder, KP,期刊：Journal of clinical investigation, 页码：2686-2689 , 文章类型： Editorial Material，,卷期：2008年118-8] Enzyme replacement therapy (ERT) for the lysosomal storage disease mucopolysaccharidosis I (MPS I) involves i.v. injection of alpha-L-iduronidase, which can be taken up by cells throughout the body. While a significant i... It takes two to tango: cigarette smoke partners with viruses to promote emphysema [作者：Tuder, RM; Yun, JH,期刊：Journal of clinical investigation, 页码：2689-2693 , 文章类型： Editorial Material，,卷期：2008年118-8] Viruses constitute a constant and renewed threat to humans. Not only do viruses cause disease directly due to their tissue tropism and pathogenicity, but they have also been linked to autoimmunity. In their study in this... Lipid droplets: FSP27 knockout enhances their sizzle [作者：Puri, V; Czech, MP,期刊：Journal of clinical investigation, 页码：2693-2696 , 文章类型： Editorial Material，,卷期：2008年118-8] Fat-specific protein of 27 kDa (FSP27) is a highly expressed adipocyte protein that promotes triglyceride accumulation within lipid droplets. in this issue of the JCI, Nishino et al. show that FSP27 also helps to maintai... HHMI to support young physician-scientists [作者：[Anon],期刊：Journal of clinical investigation, 页码：2672-2672 , 文章类型： News Item，,卷期：2008年118-8] APRIL secreted by neutrophils binds to heparan sulfate proteoglycans to create plasma cell niches in human mucosa [作者：Huard, B; Mckee, T; Bosshard, C; Durual, S; Matthes, T; Myit, S; Donze, O; Frossard, C; Chizzolini, C; Favre, C; Zubler, R; Guyot, JP; Schneider, P; Roosnek, E,期刊：Journal of clinical investigation, 页码：2887-2895 , 文章类型： Article，,卷期：2008年118-8] The bone marrow constitutes a favorable environment for long-lived antibody-secreting plasma cells, providing blood-circulating antibody. Plasma cells are also present in mucosa-associated lymphoid tissue (MALT) to media... B cell receptor revision diminishes the autoreactive B cell response after antigen activation in mice [作者：Wang, YH; Diamond, B,期刊：Journal of clinical investigation, 页码：2896-2907 , 文章类型： Article，,卷期：2008年118-8] Autoreactive B cells are regulated in the BM during development through mechanisms, including editing of the B cell receptor (BCR), clonal deletion, and anergy. Peripheral B cell tolerance is also important for protectio... Mutant prominin 1 found in patients with macular degeneration disrupts photoreceptor disk morphogenesis in mice [作者：Yang, ZL; Chen, YL; Lillo, C; Chien, J; Yu, ZY; Michaelides, M; Klein, M; Howes, KA; Li, Y; Kaminoh, Y; Chen, HY; Zhao, C; Chen, YH; Al-Sheikh, YT; Karan, G; Corbeil, D; Escher, P; Kamaya, S; Li, CM; Johnson, S; Frederick, JM; Zhao, Y; Wang, CG; Cameron, DJ; Huttner, WB; Schorderet, DF; Munier, FL; Moore, AT; Birch, DG; Baehr, W; Hunt, DM; Williams, DS; Zhang, K,期刊：Journal of clinical investigation, 页码：2908-2916 , 文章类型： Article，,卷期：2008年118-8] Familial macular degeneration is a clinically and genetically heterogeneous group of disorders characterized by progressive central visionloss. Here we show that an R373C missense mutation in the prominin 1 gene (PROM1) ... Host-derived oxidized phospholipids and HDL regulate innate immunity in human leprosy [作者：Cruz, D; Watson, AD; Miller, CS; Montoya, D; Ochoa, MT; Sieling, PA; Gutierrez, MA; Navab, M; Reddy, ST; Witztum, JL; Fogelman, AM; Rea, TH; Eisenberg, D; Berliner, J; Modlin, RL,期刊：Journal of clinical investigation, 页码：2917-2928 , 文章类型： Article，,卷期：2008年118-8] Intracellular pathogens survive by evading the host immune system and accessing host metabolic pathways to obtain nutrients for their growth. Mycobacterium leprae, the causative agent of leprosy, is thought to be the myc...