- Platelet glycoprotein lb alpha forms catch bonds with human WT vWF but not with type 2B von Willebrand disease vWF
[作者:Yago, T; Lou, J; Wu, T; Yang, J; Miner, JJ; Coburn, L; Lopez, JA; Cruz, MA; Dong, JF; McIntire, LV; McEver, RP; Zhu, C,期刊:Journal of clinical investigation, 页码:3195-3207 , 文章类型: Article,,卷期:2008年118-9]
- Arterial blood flow enhances glycoprotein Ib alpha. (GPIb alpha) binding to vWF, which initiates platelet adhesion to injured vessels. Mutations in the vWF A1 domain that cause type 2B von Willebrand disease (vWD) reduce...
- Misfolded proteins activate Factor XII in humans, leading to kallikrein formation without initiating coagulation
[作者:Maas, C; Govers-Riemslag, JWP; Bouma, B; Schiks, B; Hazenberg, BPC; Lokhorst, HM; Hammarstrom, P; ten Cate, H; de Groot, PG; Bouma, BN; Gebbink, MFBG,期刊:Journal of clinical investigation, 页码:3208-3218 , 文章类型: Article,,卷期:2008年118-9]
- When blood is exposed to negatively charged surface materials such as glass, an enzymatic cascade known as the contact system becomes activated. This cascade is initiated by autoactivation of Factor XII and leads to both...
- beta(3)-adrenergic receptor activation increases human atrial tissue contractility and stimulates the L-type Ca2+ current
[作者:Skeberdis, VA; Gendvilliene, V; Zablockaite, D; Treinys, R; Macianskiene, R; Bogdelis, A; Jurevicius, J; Fischmeister, R,期刊:Journal of clinical investigation, 页码:3219-3227 , 文章类型: Article,,卷期:2008年118-9]
- beta(3)-adrenergic receptor (beta(3)-AR) activation produces a negative inotropic effect in human ventricles. Here we explored the role of [beta(3)-AR in the human atrium. Unexpectedly, beta(3)-AR activation increased hu...
- A novel panel of mouse models to evaluate the role of human pregnane X receptor and constitutive androstane receptor in drug response
[作者:Scheer, N; Ross, J; Rode, A; Zevnik, B; Niehaves, S; Faust, N; Wolf, CR,期刊:Journal of clinical investigation, 页码:3228-3239 , 文章类型: Article,,卷期:2008年118-9]
- The pregnane X receptor (PXR) and the constitutive androstane receptor (CAR) are closely related orphan nuclear hormone receptors that play a critical role as xenobiotic sensors in mammals. Both receptors regulate the ex...
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