- KBMA Listeria monocytogenes is an effective vector for DC-mediated induction of antitumor immunity
[作者:Skoberne, M; Yewdall, A; Bahjat, KS; Godefroy, E; Lauer, P; Lemmens, E; Liu, WQ; Luckett, W; Leong, M; Dubensky, TW; Brockstedt, DG; Bhardwaj, N,期刊:Journal of clinical investigation, 页码:3990-4001 , 文章类型: Article,,卷期:2008年118-12]
- Vaccine strategies that utilize human DCs to enhance antitumor immunity have yet to realize their full potential. Approaches that optimally target a spectrum of antigens to DCs are urgently needed. Here we report the dev...
- apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain
[作者:Deane, R; Sagare, A; Hamm, K; Parisi, M; Lane, S; Finn, MB; Holtzman, DM; Zlokovic, BV,期刊:Journal of clinical investigation, 页码:4002-4013 , 文章类型: Article,,卷期:2008年118-12]
- Neurotoxic amyloid beta peptide (A beta) accumulates in the brains of individuals with Alzheimer disease (AD). The APOE4 allele is a major risk factor for sporadic AD and has been associated with increased brain parenchy...
- Endogenous prolactin-releasing peptide regulates food intake in rodents
[作者:Takayanagi, Y; Matsumoto, H; Nakata, M; Mera, T; Fukusumi, S; Hinuma, S; Ueta, Y; Yada, T; Leng, G; Onaka, T,期刊:Journal of clinical investigation, 页码:4014-4024 , 文章类型: Article,,卷期:2008年118-12]
- Food intake is regulated by a network of signals that emanate from the gut and the brainstem. The peripheral satiety signal cholecystokinin is released from the gut following food intake and acts on fibers of the vagus n...
- 17 beta-Estradiol inhibits Ca2+-dependent homeostasis of airway surface liquid volume in human cystic fibrosis airway epithelia
[作者:Coakley, RD; Sun, H; Clunes, LA; Rasmussen, JE; Stackhouse, JR; Okada, SF; Fricks, I; Young, SL; Tarran, R,期刊:Journal of clinical investigation, 页码:4025-4035 , 文章类型: Article,,卷期:2008年118-12]
- Normal airways homeostatically regulate the volume of airway surface liquid through both cAMP- and Ca2+-dependent regulation of ion and water transport. In cystic fibrosis (CF), a genetic defect causes a lack of cAMP-reg...
- Invariant NKT cells reduce the immunosuppressive activity of influenza A virus-induced myeloid-derived suppressor cells in mice and humans
[作者:De Santo, C; Salio, M; Masri, SH; Lee, LYH; Dong, T; Speak, AO; Porubsky, S; Booth, S; Veerapen, N; Besra, GS; Groene, HJ; Platt, FM; Zambon, M; Cerundolo, V,期刊:Journal of clinical investigation, 页码:4036-4048 , 文章类型: Article,,卷期:2008年118-12]
- infection with influenza A virus (IAV) presents a substantial threat to public health worldwide, with young, elderly, and immunodeficient individuals being particularly susceptible. Inflammatory responses play an importa...
- Intracellular alkalization causes pain sensation through activation of TRPA1 in mice
[作者:Fujita, F; Uchida, K; Moriyama, T; Shima, A; Shibasaki, K; Inada, H; Sokabe, T; Tominaga, M,期刊:Journal of clinical investigation, 页码:4049-4057 , 文章类型: Article,,卷期:2008年118-12]
- Vertebrate cells require a very narrow pH range for survival. Cells accordingly possess sensory and defense mechanisms for situations where the pH deviates from the viable range. Although the monitoring of acidic pH by s...
- Real-time assessment of inflammation and treatment response in a mouse model of allergic airway inflammation
[作者:Cortez-Retamozo, V; Swirski, FK; Waterman, P; Yuan, H; Figueiredo, JL; Newton, AP; Upadhyay, R; Vinegoni, C; Kohler, R; Blois, J; Smith, A; Nahrendorf, M; Josephson, L; Weissleder, R; Pittet, MJ,期刊:Journal of clinical investigation, 页码:4058-4066 , 文章类型: Article,,卷期:2008年118-12]
- Eosinophils are multifunctional leukocytes that degrade and remodel tissue extracellular matrix through production of proteolytic enzymes, release of proinflammatory factors to initiate and propagate inflammatory respons...
- Possible dual roles for prostacyclin in human pregnancy and labor
[作者:Taggart, MJ; Europe-Finner, GN; Mitchell, BF,期刊:Journal of clinical investigation, 页码:3829-3832 , 文章类型: Editorial Material,,卷期:2008年118-12]
- During pregnancy, the muscular layer of the uterine wall known as the myometrium, which is composed mainly of smooth muscle cells, is maintained in a state of relative quiescence. A switch from myometrial quiescence to m...
|