- Deletion of the von Hippel-Lindau gene in pancreatic beta cells impairs glucose homeostasis in mice
[作者:Cantley, J; Selman, C; Shukla, D; Abramov, AY; Forstreuter, F; Esteban, MA; Claret, M; Lingard, SJ; Clements, M; Harten, SK; Asare-Anane, H; Batterham, RL; Herrera, PL; Persaud, SJ; Duchen, MR; Maxwell, PH; Withers, DJ,期刊:Journal of clinical investigation, 页码:125-135 , 文章类型: Article,,卷期:2009年119-1]
- Defective insulin secretion in response to glucose is an important component of the beta cell dysfunction seen in type 2 diabetes. As mitochondrial oxidative phosphorylation plays a key role in glucose-stimulated insulin...
- Mutant Hoxd13 induces extra digits in a mouse model of synpolydactyly directly and by decreasing retinoic acid synthesis
[作者:Kuss, P; Villavicencio-Lorini, P; Witte, F; Klose, J; Albrecht, AN; Seemann, P; Hecht, J; Mundlos, S,期刊:Journal of clinical investigation, 页码:146-156 , 文章类型: Article,,卷期:2009年119-1]
- Individuals with the birth defect synpolydactyly (SPD) have 1 or more digit duplicated and 2 or more digits fused together. One form of SPD is caused by polyalanine expansions in homeobox d13 (Hoxd13). Here we have used ...
- Harnessing endogenous miR-181a to segregate transgenic antigen receptor expression in developing versus post-thymic T cells in murine hematopoietic chimeras
[作者:Papapetrou, EP; Kovalovsky, D; Beloeil, L; Sant'Angelo, D; Sadelain, M,期刊:Journal of clinical investigation, 页码:157-168 , 文章类型: Article,,卷期:2009年119-1]
- MicroRNAs (miRNAs) are small, noncoding RNAs that regulate gene expression by targeting complementary sequences, referred to as miRNA recognition elements (MREs), typically located in the 3' untranslated region of mRNAs....
- Infiltration of CD4(+) lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease
[作者:Brochard, V; Combadiere, B; Prigent, A; Laouar, Y; Perrin, A; Beray-Berthat, V; Bonduelle, O; Alvarez-Fischer, D; Callebert, J; Launay, JM; Duyckaerts, C; Flavell, RA; Hirsch, EC; Hunot, S,期刊:Journal of clinical investigation, 页码:182-192 , 文章类型: Article,,卷期:2009年119-1]
- Parkinson disease (PD) is a neurodegenerative disorder characterized by a loss of dopamine-containing neurons. Mounting evidence suggests that dopaminergic cell death is influenced by the innate immune system. However, t...
- IRBIT coordinates epithelial fluid and HCO(3)(-)secretion by stimulating the transporters pNBC1 and CFTR in the murine pancreatic duct
[作者:Yang, DK; Shcheynikov, N; Zeng, WZ; Ohana, E; So, I; Ando, H; Mizutani, A; Mikoshiba, K; Muallem, S,期刊:Journal of clinical investigation, 页码:193-202 , 文章类型: Article,,卷期:2009年119-1]
- Fluid and HCO3- secretion are vital functions of secretory epithelia. In most epithelia, this entails HCO(3)(-)entry at the basolateral membrane, mediated by the Na+-HCO3- cotransporter, pNBC1, and exit at the luminal me...
- Endoplasmic reticulum-mitochondria crosstalk in NIX-mediated murine cell death
[作者:Diwan, A; Matkovich, SJ; Yuan, QY; Zhao, W; Yatani, A; Brown, JH; Molkentin, JD; Kranias, EG; Dorn, GW,期刊:Journal of clinical investigation, 页码:203-212 , 文章类型: Article,,卷期:2009年119-1]
- Transcriptional upregulation of the proapoptotic BCL2 family protein NIX limits red blood cell formation and can cause heart failure by inducing cell death, but the requisite molecular events are poorly defined. Here, we...
- Epithelial cell alpha 3 beta 1 integrin links beta-catenin and Smad signaling to promote myofibroblast formation and pulmonary fibrosis
[作者:Kim, KK; Wei, Y; Szekeres, C; Kugler, MC; Wolters, PJ; Hill, ML; Frank, JA; Brumwell, AN; Wheeler, SE; Kreidberg, JA; Chapman, HA,期刊:Journal of clinical investigation, 页码:213-224 , 文章类型: Article,,卷期:2009年119-1]
- Pulmonary fibrosis, in particular idiopathic pulmonary fibrosis (IPF), results from aberrant wound healing and scarification. One population of fibroblasts involved in the fibrotic process is thought to originate from lu...
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