- Spinal leptin contributes to the pathogenesis of neuropathic pain in rodents
[作者:Lim, G; Wang, SX; Zhang, Y; Tian, YH; Mao, JR,期刊:Journal of clinical investigation, 页码:295-304 , 文章类型: Article,,卷期:2009年119-2]
- Pain after nerve injury, a phenomenon referred to as neuropathic pain, is a debilitating clinical condition, but the underlying mechanisms remain unclear. As leptin, an adipocytokine produced mainly by nonneuronal tissue...
- Acetaminophen-induced hepatotoxicity in mice is dependent on Tlr9 and the Nalp3 inflammasome
[作者:Imaeda, AB; Watanabe, A; Sohail, MA; Mahmood, S; Mohamadnejad, M; Sutterwala, FS; Flavell, RA; Mehall, WZ,期刊:Journal of clinical investigation, 页码:305-314 , 文章类型: Article,,卷期:2009年119-2]
- Hepatocyte death results in a sterile inflammatory response that amplifies the initial insult and increases overall tissue injury. One important example of this type of injury is acetaminophen-induced liver injury, in wh...
- Postreceptor insulin resistance contributes to human dyslipidemia and hepatic steatosis
[作者:Semple, RK; Sleigh, A; Murgatroyd, PR; Adams, CA; Bluck, L; Jackson, S; Vottero, A; Kanabar, D; Charlton-Menys, V; Durrington, P; Soos, MA; Carpenter, TA; Lomas, DJ; Cochran, EK; Gorden, P; O'Rahilly, S; Savage, DB,期刊:Journal of clinical investigation, 页码:315-322 , 文章类型: Article,,卷期:2009年119-2]
- Metabolic dyslipidemia is characterized by high circulating triglyceride (TG) and low HDL cholesterol levels and is frequently accompanied by hepatic steatosis. Increased hepatic lipogenesis contributes to both of these ...
- Maternal high-fat diet triggers lipotoxicity in the fetal livers of nonhuman primates
[作者:McCurdy, CE; Bishop, JM; Williams, SM; Grayson, BE; Smith, MS; Friedman, JE; Grove, KL,期刊:Journal of clinical investigation, 页码:323-335 , 文章类型: Article,,卷期:2009年119-2]
- Maternal obesity is thought to increase the offspring's risk of juvenile obesity and metabolic diseases; however, the mechanism(s) whereby excess maternal nutrition affects fetal development remain poorly understood. Her...
- Identification of a bone marrow-derived epithelial-like population capable of repopulating injured mouse airway epithelium
[作者:Wong, AP; Keating, A; Lu, WY; Duchesneau, P; Wang, XH; Sacher, A; Hu, J; Waddell, TK,期刊:Journal of clinical investigation, 页码:336-348 , 文章类型: Article,,卷期:2009年119-2]
- The bone marrow compartment is enriched in stem and progenitor cells, and an unidentified subpopulation of these cells can contribute to lung epithelial repair. Here we identify this subpopulation and quantitate its rela...
- Human four-and-a-half LIM family members suppress tumor cell growth through a TGF-beta-like signaling pathway
[作者:Ding, LH; Wang, ZY; Yan, JH; Yang, X; Liu, AJ; Qiu, WY; Zhu, JH; Han, JQ; Zhang, H; Lin, J; Cheng, L; Qin, X; Niu, C; Yuan, B; Wang, XH; Zhu, C; Zhou, Y; Li, JZ; Song, HF; Huang, CF; Ye, QN,期刊:Journal of clinical investigation, 页码:349-361 , 文章类型: Article,,卷期:2009年119-2]
- The four-and-a-half LIM (FHL) proteins belong to a family of LIM-only proteins that regulate cell proliferation, differentiation, and apoptosis. The exact functions of each FHL protein in cancer development and progressi...
- PIM-1-specific mAb suppresses human and mouse tumor growth by decreasing PIM-1 levels, reducing Akt phosphorylation, and activating apoptosis
[作者:Hu, XF; Li, J; Vandervalk, S; Wang, ZP; Magnuson, NS; Xing, PX,期刊:Journal of clinical investigation, 页码:362-375 , 文章类型: Article,,卷期:2009年119-2]
- Provirus integration site for Moloney murine leukemia virus (PIM1) is a proto-oncogene that encodes a serine/threonine kinase with multiple cellular functions. Overexpression of PIM-1 plays a critical role in progression...
- Loss of viral fitness and cross-recognition by CD8(+) T cells limit HCV escape from a protective HLA-B27-restricted human immune response
[作者:Dazert, E; Neumann-Haefelin, C; Bressanelli, S; Fitzmaurice, K; Kort, J; Timm, J; McKiernan, S; Kelleher, D; Gruener, N; Tavis, JE; Rosen, HR; Shaw, J; Bowness, P; Bium, HE; Klenerman, P; Bartenschlager, R; Thimme, R,期刊:Journal of clinical investigation, 页码:376-386 , 文章类型: Article,,卷期:2009年119-2]
- There is an association between expression of the MHC class I molecule HLA-1327 and protection following human infection with either HIV or HCV. In both cases, protection has been linked to HLA-B27 presentation of a sing...
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