- Synthesis of isofagomine and a new C6 pyrrolidine azasugar with potential biological activity.
[作者:Espeel, Pieter E. R.;Piens, Kathleen;Callewaert, Nico;Van der Eycken, Johan;,期刊:SYNLETT, 页码:2321-2325 , 文章类型: 研究论文,,卷期:2008年-15]
- An efficient asym. synthesis of isofagomine, based on a precursor contg. 3 differentiated hydroxyl functions, is described. The side product in the key alkylation step is converted into (2S,3R,4R)-2,4-bis(hydroxymethyl)...
- New route to natural camptothecin through isomunchnone cycloaddition.
[作者:Kanazawa, Alice;Muniz, Mauro N.;Baumlova, Barbora;Ljungdahl, Natalie;Greene, Andrew E.;,期刊:SYNLETT, 页码:2275-2278 , 文章类型: 研究论文,,卷期:2008年-15]
- A novel approach to camptothecin (I) is described employing [3+2] cycloaddn. of isomunchnone intermediate II, a Suzuki coupling, and a Shibasaki enantioselective cyanosilylation. The synthesis requires 12 steps and proc...
- Valuable versatile reactivity of thiaisatoic anhydrides: expedient solid-phase synthesis of thieno[1,4]diazepine-2,5-diones.
[作者:Brouillette, Yann;Verdie, Pascal;Martinez, Jean;Lisowski, Vincent;,期刊:SYNLETT, 页码:2360-2364 , 文章类型: 研究论文,,卷期:2008年-15]
- An expedient route for the generation of substituted thieno[3,2-e][1,4]diazepine-2,5-dione analogs is described. In soln., thiaisatoic anhydride and its N-alkylated equiv. react in opposite ways with amino acids in basi...
- Regioselective preparation of N-methylpyrazole derivative.
[作者:Profeta, Roberto;Mattioli, Mario;Micheli, Fabrizio;Piga, Elisa;Spada, Simone;Tarsi, Luca;Andreotti, Daniele;,期刊:SYNLETT, 页码:2283-2286 , 文章类型: 研究论文,,卷期:2008年-15]
- A novel high-yielding and regioselective method to prep. N-methylpyrazoles is reported by reaction of an N-Boc-N-methylhydrazone with an arom. alkyl ester.
- An efficient protocol for multicomponent stereoselective synthesis of 3-amino-2(1H)-pyridinones using CeCl3.7H2O/NaI as a reaction promoter.
[作者:Yadav, Lal Dhar S.;Kapoor, Ritu;,期刊:SYNLETT, 页码:2348-2354 , 文章类型: 研究论文,,卷期:2008年-15]
- 2-phenyl-1,3-oxazolin-5-one, and amines is reported. The protocol involves sequential Michael addn., condensation, ring transformation, and acid hydrolysis. Operational simplicity, ambient temp., high yields, and diast...
- A catalytic asymmetric Fujiwara-Moritani cyclization.
[作者:Schiffner, Julia A.;Machotta, Axel B.;Oestreich, Martin;,期刊:SYNLETT, 页码:2271-2274 , 文章类型: 研究论文,,卷期:2008年-15]
- An enantioselective intramol. Fujiwara-Moritani reaction involving direct C-H functionalization using modified PyOX ligands is reported for the first time. Screening of several ligand-oxidant combinations eventually pro...
- Synthesis of 7,8,9-trisubstituted dihydropurine derivatives via a "tert-amino effect" cyclization.
[作者:Che, Xin;Zheng, Lianyou;Dang, Qun;Bai, Xu;,期刊:SYNLETT, 页码:2373-2375 , 文章类型: 研究论文,,卷期:2008年-15]
- 7,8,9-Trisubstituted dihydropurine derivs. were prepd. from 5-amino-4-(N,N-disubstituted)aminopyrimidines and arom. aldehydes via a cascade of reactions. The key transformation for the reaction is a [1,6]-H shift due to...
- Convergent synthesis of the A-J ring system of yessotoxin.
[作者:Torikai, Kohei;Watanabe, Koji;Minato, Hiroaki;Imaizumi, Tomoyoshi;Murata, Michio;Oishi, Tohru;,期刊:SYNLETT, 页码:2368-2372 , 文章类型: 研究论文,,卷期:2008年-15]
- A highly convergent synthesis of the A-J ring system (I) of yessotoxin was achieved. A convergent strategy via a-cyano ethers was extensively applied in the assembly of the F and IJ ring fragments to afford the FGHIJ ri...
- Pd/C-catalyzed direct a-oxygenation of 1,3-dicarbonyl compounds using molecular oxygen.
[作者:Monguchi, Yasunari;Takahashi, Tohru;Iida, Yusuke;Fujiwara, Yuta;Inagaki, Yuya;Maegawa, Tomohiro;Sajiki, Hironao;,期刊:SYNLETT, 页码:2291-2294 , 文章类型: 研究论文,,卷期:2008年-15]
- A hydroxyl group was readily and directly introduced into the a-position of a variety of b-dicarbonyl compds. by heterogeneous Pd/C-catalyzed oxygenation using mol. oxygen.
- Probing the amino-end reactivity of sulfonimidamides.
[作者:Azzaro, Stephane;Fensterbank, Louis;Lacote, Emmanuel;Malacria, Max;,期刊:SYNLETT, 页码:2253-2256 , 文章类型: 研究论文,,卷期:2008年-15]
- The amino terminus of sulfonimidamides was functionalized through a Mitsunobu reaction. The new sulfonimidamides were engaged in oxidative reactions to provide N-heterocycles.
- Catalytic conjugate addition of cyanide to enones: cooperative catalysis of Ni(0) and Gd(OTf)3.
[作者:Tanaka, Yuta;Kanai, Motomu;Shibasaki, Masakatsu;,期刊:SYNLETT, 页码:2295-2298 , 文章类型: 研究论文,,卷期:2008年-15]
- An efficient, synthetically useful catalytic conjugate addn. of cyanide to enones was developed using cooperative catalysis of Ni(0) and Gd(OTf)3. The co-catalyst, Gd(OTf)3, dramatically accelerated the reaction. The s...
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