- Syntheses and Biological Evaluation of B-Ring-Modified Analogues of Dafachronic Acid A.
[作者:Giroux, Simon;Bethke, Axel;Fielenbach, Nicole;Antebi, Adam;Corey, E. J.;,期刊:Organic Letters, 页码:3643-3645 , 文章类型: 研究论文,,卷期:2008年10-16]
- derivs. II and I (R = H) have revealed that I (R2 = bond), and not a further oxidn. product, is the natural ligand for the DAF-12 receptor of Caenorhabditis elegans.
- Flexible Strategy for the Synthesis of Pyrrolizidine Alkaloids.
[作者:Donohoe, Timothy J.;Thomas, Rhian E.;Cheeseman, Matthew D.;Rigby, Caroline L.;Bhalay, Gurdip;Linney, Ian D.;,期刊:Organic Letters, 页码:3615-3618 , 文章类型: 研究论文,,卷期:2008年10-16]
- A general strategy for the prodn. of pyrrolizidine alkaloids is described, starting from pyrroline intermediate (+)-I. The key features are diastereoselective dihydroxylation, inversion at the ring junction by hydrobora...
- Total Synthesis of Aristolactams via a One-Pot Suzuki-Miyaura Coupling/Aldol Condensation Cascade Reaction.
[作者:Kim, Joa Kyum;Kim, Young Ha;Nam, Ho Tae;Kim, Bum Tae;Heo, Jung-Nyoung;,期刊:Organic Letters, 页码:3543-3546 , 文章类型: 研究论文,,卷期:2008年10-16]
- A direct one-pot synthesis of phenanthrene lactams, which employs a Suzuki-Miyaura coupling/aldol condensation cascade reaction of isoindolin-1-one with 2-formylphenylboronic acid, has been developed. The approach is use...
- Consecutive Cyclization of Allylaminoalkene by Intramolecular Aminolithiation-Carbolithiation.
[作者:Tsuchida, Susumu;Kaneshige, Atsunori;Ogata, Tokutaro;Baba, Hiromi;Yamamoto, Yasutomo;Tomioka, Kiyoshi;,期刊:Organic Letters, 页码:3635-3638 , 文章类型: 研究论文,,卷期:2008年10-16]
- Consecutive cyclization of allylaminoalkenes, e.g. I, by tandem aminolithiation-carbolithiation proceeded smoothly by using a lithium amide as a lithiating agent as well as protonating agent to give bicyclic amines II (R...
- a-Pyridylation of chiral amines via urea coupling, lithiation and rearrangement.
[作者:Clayden, Jonathan;Hennecke, Ulrich;,期刊:Organic Letters, 页码:3567-3570 , 文章类型: 研究论文,,卷期:2008年10-16]
- Bromo-substituted pyridines, along with other brominated electron-deficient arenes, undergo palladium-catalyzed coupling with ureas of structure RNMeCONHMe. Where R is a chiral, a-substituted benzyl group, treatment wit...
- Organocatalytic Stereoselective Mannich Reaction of 3-Substituted Oxindoles.
[作者:Tian, Xu;Jiang, Kun;Peng, Jing;Du, Wei;Chen, Ying-Chun;,期刊:Organic Letters, 页码:3583-3586 , 文章类型: 研究论文,,卷期:2008年10-16]
- The asym. Mannich reaction of 3-substituted oxindoles, e.g. I (R = PhCH2, 4-FC6H4, Pr, etc.), and N-Boc imines, e.g. R1CH:NBoc (R1 = Ph, 2-thienyl, iso-Pr, etc.), was investigated for the first time, employing bifunction...
- Highly Electron-Donating 3,3'-Diaryl-1,1'-bi(isobenzofuran)s Synthesized by Photochemical Exocyclic [2 + 2 + 2] Cycloaddition.
[作者:Zhang, Hongyu;Wakamiya, Atsushi;Yamaguchi, Shigehiro;,期刊:Organic Letters, 页码:3591-3594 , 文章类型: 研究论文,,卷期:2008年10-16]
- Facile photochem. exocyclic [2 + 2 + 2] cycloaddn. produced a series of electron-donating 1,1'-bi(isobenzofuran)s I [Ar = Ph, 3,5-(MeO)2C6H3, 2-thenyl, 4-pyridyl, etc.] having various aryl groups at the 3,3' positions. T...
- Total Synthesis of GEX1A.
[作者:Murray, Timothy J.;Forsyth, Craig J.;,期刊:Organic Letters, 页码:3429-3431 , 文章类型: 研究论文,,卷期:2008年10-16]
- An efficient and readily modifiable synthesis of GEX1A/herboxidiene/TAN-1609 (I) was developed. This modular synthesis featured a Suzuki coupling to install the conjugated diene and a Ru-catalyzed lactonization and Rous...
- Magnesium Nitride as a Convenient Source of Ammonia: Preparation of Primary Amides.
[作者:Veitch, Gemma E.;Bridgwood, Katy L.;Ley, Steven V.;,期刊:Organic Letters, 页码:3623-3625 , 文章类型: 研究论文,,卷期:2008年10-16]
- The use of magnesium nitride (Mg3N2) as a convenient source of ammonia has been explored for the direct transformation of esters to primary amides. Me, Et, iso-Pr, and tert-Bu esters are converted to the corresponding c...
- p-Stacking Effect on Levoglucosenone Derived Internal Chiral Auxiliaries. A Case of Complete Enantioselectivity Inversion on the Diels-Alder Reaction.
[作者:Sarotti, Ariel M.;Fernandez, Israel;Spanevello, Rolando A.;Sierra, Miguel A.;Suarez, Alejandra G.;,期刊:Organic Letters, 页码:3389-3392 , 文章类型: 研究论文,,卷期:2008年10-16]
- Detailed quantum chem. calcns., exptl. evidence, and NMR data rationalize the participation of p-stacking interaction in the highly asym. Diels-Alder reaction using levoglucosenone derived internal chiral auxiliaries, in...
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